Results 91 to 100 of about 1,204,901 (187)

CaV1.2 dynamics in native male arterial myocytes

The Journal of Physiology, Volume 604, Issue 15, Page 6302-6323, 1 August 2026.
Abstract figure legend Proposed model of microtubule‐dependent CaV1.2 reorganization in vascular disease. Schematic illustration of microtubule‐mediated delivery and stabilization of CaV1.2 channels into enlarged plasma membrane clusters in response to Ang II or hyperglycaemia, promoting cooperative gating and enhanced Ca2+ influx. Abstract L‐type CaV1.
Miguel Martin‐Aragon Baudel, Hannah Voorhees, Arsalan U. Syed, Maryann K. Ferrara, Mary Horne, Johannes W. Hell, Luis F. Santana, Rose E. Dixon, Madeline Nieves‐Cintron, Manuel F. Navedo   +9 more
wiley   +1 more source

Kv7 (KCNQ) potassium channels that are mutated in human diseases [PDF]

The Journal of Physiology, 2008
Kv7 channels are a small family of voltage-gated potassium channel subunits (Kv7.1–Kv7.5) that are encoded by the KCNQ genes (KCNQ1–5) (reviewed by Jentsch, 2000; and by Robbins, 2001). Structurally, they resemble other Kv channels, with six transmembrane domains, a voltage sensor in the fourth (S4) domain, and a pore loop between the S5 and S6 domains,
openaire   +2 more sources

Electro‐Mechanical Uncoupling of KV7.1 Voltage Sensor and Pore by 1,4‐Benzodiazepines Is Modulated by Decoration of Position 1

Archiv der Pharmazie, Volume 359, Issue 7, July 2026.
Loss‐of‐function mutations of the voltage‐gated potassium channel KV7.1 (KCNQ1) can lead to malignant arrhythmia. The effects of five 1,4‐benzodiazepines modified at the lactam on KV7.1 gating were thoroughly analysed by two‐electrode voltage clamp experiments.
Florian Roßner, Thomas Jepps, Bo Hjorth Bentzen, Nathalie Strutz‐Seebohm, Bernhard Wünsch, Guiscard Seebohm   +5 more
wiley   +1 more source

Reduced axonal surface expression and phosphoinositide sensitivity in Kv7 channels disrupts their function to inhibit neuronal excitability in Kcnq2 epileptic encephalopathy

Neurobiology of Disease, 2018
Neuronal Kv7/KCNQ channels are voltage-gated potassium channels composed of Kv7.2/KCNQ2 and Kv7.3/KCNQ3 subunits. Enriched at the axonal membrane, they potently suppress neuronal excitability. De novo and inherited dominant mutations in Kv7.2 cause early
Eung Chang Kim, Jiaren Zhang, Weilun Pang, Shuwei Wang, Kwan Young Lee, John P. Cavaretta, Jennifer Walters, Erik Procko, Nien-Pei Tsai, Hee Jung Chung   +9 more
doaj   +1 more source

Discovery of Novel Bicyclic Pyrazole Amides as Potent Neuronal K_V7 Potassium Channel Openers with Strong Preclinical Antiseizure Activity. [PDF]

ACS Med Chem Lett
There has been considerable interest in developing openers of neuronal KV7 potassium channels, particularly KV7.2 (KCNQ2) and KV7.3 (KCNQ3), as both genetic and clinical evidence strongly support their therapeutic potential in seizure disorders.
Sun S, Jia Q, Bankar G, Burford KN, Christabel J, Clement HA, de Boer G, Feng Z, Hambira CM, Jackson SK, Khakh K, Kwan R, Lee S, Li J, Lindgren A, Mezeyova J, Sabbatini J, Urrutia A, Charifson P, Clark MP, Wesolowski SS, Johnson JP, Empfield JR, Dehnhardt CM, Dean R.   +24 more
europepmc   +2 more sources

Epilepsy: Epidemiology, Molecular Pathogenesis, and Clinical Management

MedComm, Volume 7, Issue 7, July 2026.
Epilepsy is a heterogeneous and chronically evolving brain network disorder. This review integrates epidemiological burden, psychiatric comorbidities, and cyclic seizure patterns with multiscale pathogenic mechanisms, including ion‐channel dysfunction, synaptic transmission defects, neuroinflammation, metabolic and mitochondrial dysfunction, and ...
Jian Liu, Xinyan Wu, Ting Yin, Feining Huang, Manqi Kong, Yu Yang, Zinan Liu, Jiabin Yu, Tianpeng Zhang   +8 more
wiley   +1 more source

Role of Kv7 channels in responses of the pulmonary circulation to hypoxia

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2015
Hypoxic pulmonary vasoconstriction (HPV) is a beneficial mechanism that diverts blood from hypoxic alveoli to better ventilated areas of the lung, but breathing hypoxic air causes the pulmonary circulation to become hypertensive. Responses to airway hypoxia are associated with depolarization of smooth muscle cells in the pulmonary arteries and reduced ...
Sedivy, V, Joshi, S, Ghaly, Y, Mizera, R, Zaloudikova, M, Brennan, S, Novotna, J, Herget, J, Gurney, AM; id_orcid 0000-0001-8821-1088   +8 more
openaire   +2 more sources

Kv7 channel subtype mRNA expression in guinea pig DSM whole tissue and single-cells.

, 2013
A) Gel electrophoresis images illustrate RT-PCR detection of all Kv7 channel subtypes including Kv7.1, Kv7.2, Kv7.3, Kv7.4, and Kv7.5 channel mRNA messages in mucosa-free whole DSM tissue (N=4). At DSM single-cell level, unlike other Kv7 channel subtypes
Serge A. Y. Afeli (431004), John Malysz (461274), Georgi V. Petkov (431008)   +2 more
core   +1 more source

Role and Mechanism of Polyunsaturated Fatty Acids on Potassium Ion Channels

Shengwu huaxue yu shengwu wuli jinzhan
Polyunsaturated fatty acids (PUFAs) have diverse health-promoting effects, such as potentially protecting in immune, nervous, and cardiovascular systems by targeting a variety of sites, including most ion channels. Voltage-gated potassium channels of the
SUN Yu-Jiao, CHANG Chao, WU Zhen-Hua, ZHANG Yi-Fei, TIAN Yu-Tao   +4 more
doaj   +1 more source

A novel role of the antidepressant paroxetine in inhibiting neuronal Kv7/M channels to enhance neuronal excitability

Translational Psychiatry
The voltage-gated Kv7/KCNQ/M potassium channels exert inhibitory control over neuronal membrane excitability. The reduction of Kv7 channel function can improve neuronal excitability that defines the fundamental mechanism of learning and memory.
Huan Shi, Qinqin Li, Fang Hu, Yani Liu, KeWei Wang   +4 more
doaj   +1 more source