Results 71 to 80 of about 1,204,901 (187)

The Gβ1 and Gβ3 Subunits Differentially Regulate Rat Vascular Kv7 Channels

Frontiers in Physiology, 2020
Within the vasculature Kv7 channels are key regulators of basal tone and contribute to a variety of receptor mediated vasorelaxants. The Kv7.4 isoform, abundant within the vasculature, is key to these processes and was recently shown to have an ...
Iain A. Greenwood, Jennifer B. Stott
doaj   +1 more source

Calcium‐activated chloride channels in pericytes and their role in regulating organ blood flow

The Journal of Physiology, EarlyView.
Abstract figure legend Pericytes are microvascular mural cells with diverse roles. Contractile pericytes directly regulate local perfusion, while non‐contractile pericytes coordinate upstream vascular contractility via propagating electrical signals.
Paolo Tammaro, Hikaru Hashitani
wiley   +1 more source

Inactivation as a New Regulatory Mechanism for Neuronal Kv7 Channels [PDF]

Biophysical Journal, 2007
Voltage-gated K(+) channels of the Kv7 (KCNQ) family have important physiological functions in both excitable and nonexcitable tissue. The family encompasses five genes encoding the channel subunits Kv7.1-5. Kv7.1 is found in epithelial and cardiac tissue.
Jensen, Henrik Sindal, Grunnet, Morten, Olesen, Søren-Peter   +2 more
openaire   +3 more sources

The Natural Plant Product Rottlerin Activates Kv7.1/KCNE1 Channels

Cellular Physiology and Biochemistry, 2016
Background/Aims: Acquired as well as inherited channelopathies are disorders that are caused by altered ion channel function. A family of channels whose malfunction is associated with different channelopathies is the Kv7 K+ channel family; and ...
Veronika Matschke, Ilaria Piccini, Janina Schubert, Eva Wrobel, Florian Lang, Johann Matschke, Elsie Amedonu, Sven G. Meuth, Timo Strünker, Nathalie Strutz-Seebohm, Boris Greber, Jürgen Scherkenbeck, Guiscard Seebohm   +12 more
doaj   +1 more source

Maturation of spinal motor control through developmental changes in ion currents

The Journal of Physiology, EarlyView.
Abstract figure legend Ion channels of spinal neurons have been shown to change during development in a wide range of species. These changes occur at specific stages of development. An important developmental process is the maturation of motor control by which the body acquires new movements or refines movements already present.
Stephanie F. Gaudreau, Tuan V. Bui
wiley   +1 more source

Rosemary metabolite carnosic acid opens Kv1.1 via its voltage sensor and corrects Kv1.1‐linked episodic ataxia in mice

British Journal of Pharmacology, Volume 183, Issue 20, Page 6179-6198, October 2026.
Background and Purpose Episodic ataxia type 1 (EA1) is an autosomal dominant neurological disorder caused primarily by loss‐of‐function mutations in the voltage‐gated potassium channel Kv1.1 (KCNA1). Small molecules that restore Kv1.1 activity hold promise as targeted therapies for EA1, yet current pharmacological strategies remain limited ...
Rían W. Manville, Ryan F. Yoshimura, Hanh A. Nguyen, Ruiming Zhao, Derk J. Hogenkamp, Steve A. N. Goldstein, Geoffrey W. Abbott   +6 more
wiley   +1 more source

Polyunsaturated Fatty acids as Kv7 Channel Modulators [PDF]

Biophysical Journal, 2013
Lipids in different forms can directly affect the electric activity of excitable tissues, in some cases via direct interactions with ion channels. For instance is the activity of Kv7 (KCNQ) channels dependent on the abundance of the phospholipid PIP2 in the inner leaflet of the plasma membrane.
Liin, Sara I., Schmitt, Nicole, Bentzen, Bo H., Elinder, Fredrik   +3 more
openaire   +1 more source

Allisartan ameliorates vascular remodeling through regulation of voltage-gated potassium channels in hypertensive rats

BMC Pharmacology and Toxicology, 2021
Background The objective of the present study was to determine the effect of allisartan, a new angiotensin II type 1 receptor antagonist on vascular remodeling through voltage gated potassium channels (Kv7) in hypertensive rats.
Xiaoqin Zhang, Ziying Zhao, Chunfang Xu, Fengping Zhao, Zhiqiang Yan   +4 more
doaj   +1 more source

Repressor element 1-silencing transcription factor deficiency yields profound hearing loss through Kv7.4 channel upsurge in auditory neurons and hair cells

eLife, 2022
Repressor element 1-silencing transcription factor (REST) is a transcriptional repressor that recognizes neuron-restrictive silencer elements in the mammalian genomes in a tissue- and cell-specific manner.
Haiwei Zhang, Hongchen Li, Mingshun Lu, Shengnan Wang, Xueya Ma, Fei Wang, Jiaxi Liu, Xinyu Li, Haichao Yang, Fan Zhang, Haitao Shen, Noel J Buckley, Nikita Gamper, Ebenezer N Yamoah, Ping Lv   +14 more
doaj   +1 more source

Parvalbumin interneurons in Alzheimer's disease: Physiological insights and pathophysiological mechanisms

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
Physiological and Pathological Alterations in PV+ Neurons: Under physiological conditions, PV+ interneurons exhibit fast‐spiking properties and generate gamma oscillations at the cost of high energy consumption. In AD, PV+ neurons display abnormalities in ion channels, dendrites, neurotransmission, energy metabolism, and neural oscillations, ultimately
Mengyan Wu, Xingdong Zeng, Yongle Cai, Haonan Chen, Qianying Li, Hao Yang   +5 more
wiley   +1 more source