Kv7 Channels in Lung Diseases. [PDF]
Front Physiol, 2020 Lung diseases constitute a global health concern causing disability. According to WHO in 2016, respiratory diseases accounted for 24% of world population mortality, the second cause of death after cardiovascular diseases.
Mondejar-Parreño G +2 more
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Kv7 Channels in Cyclic-Nucleotide Dependent Relaxation of Rat Intra-Pulmonary Artery. [PDF]
Biomolecules, 2022 Pulmonary hypertension is treated with drugs that stimulate cGMP or cAMP signalling. Both nucleotides can activate Kv7 channels, leading to smooth muscle hyperpolarisation, reduced Ca2+ influx and relaxation.
Al-Chawishly M, Loveland O, Gurney AM.
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Polyunsaturated Fatty Acids as Modulators of KV7 Channels. [PDF]
Front Physiol, 2020 Voltage-gated potassium channels of the KV7 family are expressed in many tissues. The physiological importance of KV7 channels is evident from specific forms of disorders linked to dysfunctional KV7 channels, including variants of epilepsy, cardiac ...
Larsson JE, Frampton DJA, Liin SI.
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Cannabidiol activates neuronal Kv7 channels. [PDF]
Elife, 2022 Cannabidiol (CBD), a chemical found in the Cannabis sativa plant, is a clinically effective antiepileptic drug whose mechanism of action is unknown. Using a fluorescence-based thallium flux assay, we performed a large-scale screen and found enhancement ...
Zhang HB +12 more
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The Functional Availability of Arterial Kv7 Channels Is Suppressed Considerably by Large-Conductance Calcium-Activated Potassium Channels in 2- to 3-Month Old but Not in 10- to 15-Day Old Rats. [PDF]
Front Physiol, 2020 BackgroundVoltage-gated potassium (Kv) channels, especially Kv7 channels, are major potassium channels identified in vascular smooth muscle cells with a great, albeit differential functional impact in various vessels.
Ma D +4 more
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The Role of Kv7 Channels in Neural Plasticity and Behavior. [PDF]
Front Physiol, 2020 Activity-dependent persistent changes in neuronal intrinsic excitability and synaptic strength are widely thought to underlie learning and memory. Voltage-gated KCNQ/Kv7 potassium channels have been of great interest as the potential targets for memory ...
Baculis BC, Zhang J, Chung HJ.
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The Gβ1 and Gβ3 Subunits Differentially Regulate Rat Vascular Kv7 Channels. [PDF]
Front Physiol, 2019 Within the vasculature Kv7 channels are key regulators of basal tone and contribute to a variety of receptor mediated vasorelaxants. The Kv7.4 isoform, abundant within the vasculature, is key to these processes and was recently shown to have an ...
Greenwood IA, Stott JB.
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Detrusor Smooth Muscle KV7 Channels: Emerging New Regulators of Urinary Bladder Function. [PDF]
Front Physiol, 2020 Relaxation and contraction of the urinary bladder smooth muscle, also known as the detrusor smooth muscle (DSM), facilitate the micturition cycle. DSM contractility depends on cell excitability, which is established by the synchronized activity of ...
Malysz J, Petkov GV.
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Loose-patch recordings reveal differential Kv7-dependent effects on spontaneous excitatory activity in control and epileptic CA1. [PDF]
Front NeurolIntroductionThe non-inactivating potassium channels Kv7.2 and Kv7.3 contribute to the neuronal resting membrane potential and regulate neuronal excitability.
Nissen EM +4 more
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XE991 Reverses Enhanced Short-Term Plasticity in Rat Epileptic CA1. [PDF]
Brain SciBackground/Objectives: Recent evidence has suggested a transcriptional reduction in Kv7 potassium channels in the CA1 area of acquired experimental epilepsy, but presynaptic Kv7 channels might be spared.
Schnell E +3 more
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