Results 31 to 40 of about 799,860 (178)

Chemical modulation of Kv7 potassium channels

RSC Medicinal Chemistry, 2021
This review describes the synthetic and medicinal chemistry of small molecule modulators of the voltage-gated Kv7 (KCNQ) potassium channels and the available data of their biological and clinical properties.
Matteo Borgini, Pravat Mondal, Ruiting Liu, Peter Wipf   +3 more
openaire   +3 more sources

NeuralKCNQ(Kv7) channels [PDF]

British Journal of Pharmacology, 2009
KCNQgenes encode five Kv7 K+channel subunits (Kv7.1–Kv7.5). Four of these (Kv7.2–Kv7.5) are expressed in the nervous system. Kv7.2 and Kv7.3 are the principal molecular components of the slow voltage‐gated M‐channel, which widely regulates neuronal excitability, although other subunits may contribute to M‐like currents in some locations. M‐channels are
David A, Brown, Gayle M, Passmore
openaire   +2 more sources

Identification of Sodium/Myo-Inositol Transporter 1 as a Major Determinant of Arterial Contractility. [PDF]

FASEB J
The tonicity‐responsive enhancer binding‐protein (TonEBP) and serum glucocorticoid kinase (SGK) sense a rise in extracellular hypertonicity resulting in an increase SMIT1 membrane abundance in vascular smooth muscle cells. SMIT1 associates with Kv7.4/5, Gβγ, and KCNE4, promoting hyperpolarization, reduced voltage‐gated calcium channel (VGCC) opening ...
Forrester EA, Lau S, Benitez-Angeles M, Garland CJ, Barrese V, Albert AP, Greenwood IA.   +6 more
europepmc   +2 more sources

Modulation of Kv7 Channel Currents by Echinocystic Acid

Molecular Pharmacology, 2023
Modulation of KCNQ-encoded voltage-gated potassium Kv7/M channel function represents an attractive strategy to treat neuronal excitability disorders such as epilepsy, pain, and depression. The Kv7 channel group includes five subfamily members (Kv7.1-Kv7.5).
DanDan, Geng, Yaning, Li, Rong, Zheng, Runmeng, Wang, Bo, Yang, Huaxing, Zhang, Yang, Zhang, Fan, Zhang   +7 more
openaire   +2 more sources

Vascular Kv7 channels control intracellular Ca²⁺ dynamics in smooth muscle. [PDF]

Cell Calcium, 2020
Voltage-gated Kv7 (or KCNQ) channels control activity of excitable cells, including vascular smooth muscle cells (VSMCs), by setting their resting membrane potential and controlling other excitability parameters. Excitation-contraction coupling in muscle
Tsai YM, Jones F, Mullen P, Porter KE, Steele D, Peers C, Gamper N.   +6 more
europepmc   +2 more sources

Impact of Administration Time and Kv7 Subchannels on the Cardioprotective Efficacy of Kv7 Channel Inhibition.

Drug design, development and therapy, 2020
The mechanism of cardioprotection by Kv7.1-5 (KCNQ1-5) channels inhibition by XE991 is unclear. We examined the impact of administration time on the cardioprotective efficacy of XE991, the involvement of key pro-survival kinases, and the importance of the Kv7 subchannels.Isolated perfused rat hearts were divided into five groups: 1) vehicle, 2) pre-, 3)
Hansen, Jan, Johnsen, Jacob; id_orcid 0000-0002-7355-320X, Nielsen, Jan Møller, Sørensen, Charlotte Brandt, Elkjær, Casper Carlsen, Jespersen, Nichlas Riise; id_orcid 0000-0003-2502-2102, Bøtker, Hans Erik; id_orcid 0000-0001-6358-8962   +6 more
openaire   +6 more sources

Novel Roles for Kv7 Channels in Shaping Histamine-Induced Contractions and Bradykinin-Dependent Relaxations in Pig Coronary Arteries. [PDF]

PLoS ONE, 2016
Voltage-gated Kv7 channels are inhibited by agonists of Gq-protein-coupled receptors, such as histamine. Recent works have provided evidence that inhibition of vascular Kv7 channels may trigger vessel contractions.
Xingjuan Chen, Wennan Li, S Christopher Hiett, Alexander G Obukhov   +3 more
doaj   +1 more source

Could NAPQI Contribute to Paracetamol Analgesia? Redox Modulation of Kv7 Ion Channels. [PDF]

Pharmacol Res Perspect
ABSTRACT Paracetamol (acetaminophen, APAP) is one of the most widely used analgesic and antipyretic drugs worldwide, yet its mechanism of action remains incompletely understood. While several pathways have been proposed, including cyclooxygenase inhibition and endocannabinoid modulation via AM404, none fully account for its pharmacological profile. The
M-Alicante S, Urrutia J, Muguruza-Montero A, Revuelta M, Arrizabalaga-Iriondo A, Villarroel A, Nuñez E.   +6 more
europepmc   +2 more sources

KV7 Channel Expression and Function Within Rat Mesenteric Endothelial Cells

Frontiers in Physiology, 2020
Background and Purpose: Arterial diameter is dictated by the contractile state of the vascular smooth muscle cells (VSMCs), which is modulated by direct and indirect inputs from endothelial cells (ECs).
Samuel N. Baldwin, Shaun L. Sandow, Gema Mondéjar-Parreño, Jennifer B. Stott, Iain A. Greenwood   +4 more
doaj   +1 more source

From pan-reactive KV7 channel opener to subtype selective opener/inhibitor by addition of a methyl group. [PDF]

PLoS ONE, 2014
The voltage-gated potassium channels of the KV7 family (KV7.1-5) play important roles in controlling neuronal excitability and are therefore attractive targets for treatment of CNS disorders linked to hyperexcitability.
Sigrid Marie Blom, Mario Rottländer, Jan Kehler, Christoffer Bundgaard, Nicole Schmitt, Henrik Sindal Jensen   +5 more
doaj   +1 more source