Kv7 Channels as an Important Contributor to Alcohol-Induced Modulation of Neuronal Excitability in Neonatal Rat Superior Cervical Ganglion. [PDF]
CellsNormal alcohols (n-alcohols) exhibit contrasting effects on neuronal excitability; specifically, ethanol enhances neuronal firing, while hexanol suppresses it. Both compounds are known to inhibit sodium currents, yet the mechanisms behind their differing
Jeong DJ, Woo JN, Yun T, Baek M, Suh BC.
europepmc +2 more sources
The impact of hyperpolarization-activated cyclic nucleotide-gated (HCN) and voltage-gated potassium KCNQ/Kv7 channels on primary microglia function. [PDF]
J Neuroinflammation, 2020 Background Microglia are essential to maintain cell homeostasis in the healthy brain and are activated after brain injury. Upon activation, microglia polarize towards different phenotypes.
Vay SU +11 more
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Inactivation as a New Regulatory Mechanism for Neuronal Kv7 Channels [PDF]
Biophysical Journal, 2007 Voltage-gated K+ channels of the Kv7 (KCNQ) family have important physiological functions in both excitable and nonexcitable tissue. The family encompasses five genes encoding the channel subunits Kv7.1–5. Kv7.1 is found in epithelial and cardiac tissue.
Olesen, Søren-Peter +2 more
core +5 more sources
Kv7 channels can function without constitutive calmodulin tethering.
PLoS ONE, 2011 M-channels are voltage-gated potassium channels composed of Kv7.2-7.5 subunits that serve as important regulators of neuronal excitability. Calmodulin binding is required for Kv7 channel function and mutations in Kv7.2 that disrupt calmodulin binding ...
Juan Camilo Gómez-Posada +11 more
doaj +7 more sources
K<sub>V</sub>7 channel activation inhibits human and murine myometrium contractility and delays delivery in a mouse model of preterm birth. [PDF]
Commun Med (Lond)Background Spontaneous preterm birth, defined as delivery before 37 weeks of gestation, remains a global cause of neonatal illness and death, yet treatments for preterm labor remain limited.
Mansour YT +14 more
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Pirfenidone Is a Vasodilator: Involvement of KV7 Channels in the Effect on Endothelium-Dependent Vasodilatation in Type-2 Diabetic Mice. [PDF]
Front Pharmacol, 2020 Endothelial cell dysfunction and fibrosis are associated with worsening of the prognosis in patients with cardiovascular disease. Pirfenidone has a direct antifibrotic effect, but vasodilatation may also contribute to the effects of pirfenidone ...
Beck L +9 more
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Driving with no brakes: Molecular pathophysiology of Kv7 potassium channels [PDF]
Physiology, 2011 Kv7 potassium channels regulate excitability in neuronal, sensory, and muscular cells. Here, we describe their molecular architecture, physiological roles, and involvement in genetically determined channelopathies highlighting their relevance as targets ...
TAGLIALATELA, MAURIZIO +5 more
core +4 more sources
Bladder contractility is modulated by Kv7 channels in pig detrusor
European Journal of Pharmacology, 2013 Kv7 channels are involved in smooth muscle relaxation, and accordingly we believe that they constitute potential targets for the treatment of overactive bladder syndrome.
Nordling, Jørgen +5 more
core +4 more sources
Editorial: Kv7 Channels: Structure, Physiology, and Pharmacology. [PDF]
Front Physiol, 2021 Jepps TA, Barrese V, Miceli F.
europepmc +8 more sources
Endocannabinoids Tune Intrinsic Excitability in O-LM Interneurons by Direct Modulation of Postsynaptic Kv7 Channels. [PDF]
J Neurosci, 2021 International audienceKCNQ-Kv7 channels are found at the axon initial segment of pyramidal neurons, where they control cell firing and membrane potential.
Incontro S +7 more
europepmc +2 more sources