Results 11 to 20 of about 799,860 (178)
Inhibition of post-synaptic Kv7/KCNQ/M channels facilitates long-term potentiation in the hippocampus. [PDF]
PLoS ONE, 2012 Activation of muscarinic acetylcholine receptors (mAChR) facilitates the induction of synaptic plasticity and enhances cognitive function. In the hippocampus, M(1) mAChR on CA1 pyramidal cells inhibit both small conductance Ca(2+)-activated KCa2 ...
Milos M Petrovic +5 more
doaj +11 more sources
Analgesic Action of Acetaminophen via Kv7 Channels. [PDF]
Int J Mol Sci, 2022 The mechanism of acetaminophen (APAP) analgesia is at least partially unknown. Previously, we showed that the APAP metabolite N-acetyl-p-benzoquinone imine (NAPQI) activated Kv7 channels in neurons in vitro, and this activation of Kv7 channels dampened ...
Stampf JL +5 more
europepmc +4 more sources
Potassium channel-mediated NO-induced vasodilation during maturation: Dominance of Kv7 channels. [PDF]
FASEB BioadvMaturation represents a process characterized by adaptive changes, particularly in the circulatory system. However, it is not known whether, in neonates, potassium channels contribute to NO‐induced vasorelaxation at all and, if so, which potassium ...
Shvetsova AA +4 more
europepmc +5 more sources
Modulation of Kv7 channels and excitability in the brain. [PDF]
Cell Mol Life Sci, 2017 Neuronal Kv7 channels underlie a voltage-gated non-inactivating potassium current known as the M-current. Due to its particular characteristics, Kv7 channels show pronounced control over the excitability of neurons.
Greene DL, Hoshi N.
europepmc +7 more sources
Kv7 and Kv11 channels in myometrial regulation. [PDF]
Experimental Physiology, 2013 Ion channels play a key role in defining myometrial contractility. Modulation of ion channel populations is proposed to underpin gestational changes in uterine contractility associated with the transition from uterine quiescence to active labour.
Tribe, Rachel M; id_orcid +5 more
core +6 more sources
Kv7 Channels and Excitability Disorders
, 2021 Kv7.1-Kv7.5 (KCNQ1–5) K+ channels are voltage-gated K+ channels with major roles in neurons, muscle cells and epithelia where they underlie physiologically important K+ currents, such as neuronal M current and cardiac IKs. Specific biophysical properties
Haixia Gao +5 more
core +4 more sources
Cyclic AMP-Dependent Regulation of Kv7 Voltage-Gated Potassium Channels [PDF]
Frontiers in Physiology, 2020 Voltage-gated Kv7 potassium channels, encoded by KCNQ genes, have major physiological impacts cardiac myocytes, neurons, epithelial cells, and smooth muscle cells. Cyclic adenosine monophosphate (cAMP), a well-known intracellular secondary messenger, can
Jennifer van der Horst +2 more
doaj +2 more sources
The Kv7 Channel and Cardiovascular Risk Factors [PDF]
Frontiers in Cardiovascular Medicine, 2017 Potassium channels play a pivotal role in the regulation of excitability in cells such as neurons, cardiac myocytes, and vascular smooth muscle cells.
Andreas L. Fosmo, Øyvind B. Skraastad
doaj +3 more sources
Targeting Kv7 Potassium Channels for Epilepsy [PDF]
CNS DrugsVoltage-gated Kv7 potassium channels, particularly Kv7.2 and Kv.7.3 channels, play a critical role in modulating susceptibility to seizures, and mutations in genes that encode these channels cause heterogeneous epilepsy phenotypes.
Perucca, Emilio +3 more
core +4 more sources
Sexual dimorphisms in vascular KV7 channels [PDF]
Introduction: Kcnq-encoded KV7 channels (termed KV7.1-5) are essential regulators of vascular physiology and are associated with pathophysiological states, however, vascular studies on Kv7 channels to date have focussed almost solely on arteries from ...
Baldwin, S. N.
core +5 more sources