Results 41 to 50 of about 799,860 (178)

The contribution of Kv7 channels to pregnant mouse and human myometrial contractility. [PDF]

, 2011
Premature birth accounts for approximately 75% of neonatal mortality and morbidity in the developed world. Despite this, methods for identifying and treating women at risk of preterm labour are limited and many women still present in preterm labour ...
Pierce, SL, Greenwood, Iain A., Greenwood, IA, Tribe, Rachel M.; id_orcid, McCallum, LA, England, SK, McCallum, Laura A., Tribe, RM, England, Sarah K., Pierce, Stephanie L.   +9 more
core   +1 more source

Neuron-oligodendrocyte potassium shuttling at nodes of Ranvier protects against inflammatory demyelination

The Journal of Clinical Investigation, 2023
Multiple sclerosis (MS) is a progressive inflammatory demyelinating disease of the CNS. Increasing evidence suggests that vulnerable neurons in MS exhibit fatal metabolic exhaustion over time, a phenomenon hypothesized to be caused by chronic ...
Hannah Kapell, Luca Fazio, Julia Dyckow, Sophia Schwarz, Andrés Cruz-Herranz, Christina Mayer, Joaquin Campos, Elisa D’Este, Wiebke Möbius, Christian Cordano, Anne-Katrin Pröbstel, Marjan Gharagozloo, Amel Zulji, Venu Narayanan Naik, Anna Delank, Manuela Cerina, Thomas Müntefering, Celia Lerma-Martin, Jana K. Sonner, Jung Hyung Sin, Paul Disse, Nicole Rychlik, Khalida Sabeur, Manideep Chavali, Rajneesh Srivastava, Matthias Heidenreich, Kathryn C. Fitzgerald, Guiscard Seebohm, Christine Stadelmann, Bernhard Hemmer, Michael Platten, Thomas J. Jentsch, Maren Engelhardt, Thomas Budde, Klaus-Armin Nave, Peter A. Calabresi, Manuel A. Friese, Ari J. Green, Claudio Acuna, David H. Rowitch, Sven G. Meuth, Lucas Schirmer   +41 more
doaj   +1 more source

Cycling matters: Sex hormone regulation of vascular potassium channels

Channels, 2023
Sex hormones and the reproductive cycle (estrus in rodents and menstrual in humans) have a known impact on arterial function. In spite of this, sex hormones and the estrus/menstrual cycle are often neglected experimental factors in vascular basic ...
Samuel N Baldwin, Thomas A Jepps, Iain A Greenwood   +2 more
doaj   +1 more source

The role of potassium channel activation in celecoxib-induced analgesic action. [PDF]

PLoS ONE, 2013
BACKGROUND AND PURPOSE: Celecoxib (CXB) is a widely prescribed COX-2 inhibitor used clinically to treat pain and inflammation. Recently, COX-2 independent mechanisms have been described to be the targets of CXB.
Yao Mi, Xuan Zhang, Fan Zhang, Jinlong Qi, Haixia Gao, Dongyang Huang, Li Li, Hailin Zhang, Xiaona Du   +8 more
doaj   +1 more source

The expression and function of KCNQ potassium channels in human chorionic plate arteries from women with normal pregnancies and pre-eclampsia. [PDF]

PLoS ONE, 2018
Pre-eclampsia is associated with altered maternal and placental vascular reactivity. Kv7 channels (encoded by KCNQ 1-5 genes) are a potential contributor to the regulation of vascular tone in CPAs (chorionic plate arteries) during normal pregnancy.
Xiaohong Wei, Yujiao Zhang, Benlan Yin, Jing Wen, Jun Cheng, Xiaodong Fu   +5 more
doaj   +1 more source

Targeting Kv7 channels in pain pathways. [PDF]

Oncotarget, 2017
Rivera-Arconada I, Vicente-Baz J, Lopez-Garcia JA.   +2 more
europepmc   +4 more sources

The actions of Pasteurella multocida toxin on neuronal cells [PDF]

, 2014
Pasteurella multocida toxin (PMT) activates the G-proteins Gα, Gα, Gα Gα and Gα by deamidation of specific glutamine residues. A number of these alpha subunits have signalling roles in neurones.
Lax, Alistair; id_orcid, Robbins, Jon, Duricki, DA, Surguy, SM, Duricki, Denise A., Duricki, Denise, Lax, AJ, Reilly, JM, Reilly, Joanne, Surguy, Susan, Surguy, Susan M., Reilly, Joanne M., Robbins, J, Lax, Alistair J.   +13 more
core   +1 more source

Functional and molecular evidence for Kv7 channel subtypes in human detrusor from patients with and without bladder outflow obstruction.

PLoS ONE, 2015
The aim of the study was to investigate whether Kv7 channels and their ancillary β-subunits, KCNE, are functionally expressed in the human urinary bladder.
Julie Svalø, Majid Sheykhzade, Jørgen Nordling, Christina Matras, Pierre Bouchelouche   +4 more
doaj   +1 more source

The acrylamide (S)-2 as a positive and negative modulator of Kv7 channels expressed in Xenopus laevis oocytes. [PDF]

PLoS ONE, 2009
BACKGROUND: Activation of voltage-gated potassium channels of the Kv7 (KCNQ) family reduces cellular excitability. These channels are therefore attractive targets for treatment of diseases characterized by hyperexcitability, such as epilepsy, migraine ...
Sigrid Marie Blom, Nicole Schmitt, Henrik Sindal Jensen   +2 more
doaj   +1 more source

Kynurenine causes vasodilation and hypotension induced by activation of KCNQ-encoded voltage-dependent K+ channels

Journal of Pharmacological Sciences, 2015
Kynurenine is a potential contributor to hypotension in animal and human sepsis. The present study was designed to examine whether the voltage-dependent K+ channels encoded by the KCNQ gene family (Kv7 channels) mediate vasodilator effects of kynurenine ...
Kensuke Sakakibara, Guo-Gang Feng, Jiazheng Li, Takahiko Akahori, Yoshitaka Yasuda, Emi Nakamura, Noboru Hatakeyama, Yoshihiro Fujiwara, Hiroyuki Kinoshita   +8 more
doaj   +1 more source