The Kv7 Channel and Cardiovascular Risk Factors [PDF]
Frontiers in Cardiovascular Medicine, 2017 Potassium channels play a pivotal role in the regulation of excitability in cells such as neurons, cardiac myocytes, and vascular smooth muscle cells.
Andreas L. Fosmo, Øyvind B. Skraastad
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KV7 Channel Expression and Function Within Rat Mesenteric Endothelial Cells [PDF]
Frontiers in Physiology, 2020 Background and Purpose: Arterial diameter is dictated by the contractile state of the vascular smooth muscle cells (VSMCs), which is modulated by direct and indirect inputs from endothelial cells (ECs).
Samuel N. Baldwin +4 more
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M-Current Suppression, Seizures and Lipid Metabolism: A Potential Link Between Neuronal Kv7 Channel Regulation and Dietary Therapies for Epilepsy [PDF]
Frontiers in Physiology, 2020 Neuronal Kv7 channel generates a low voltage-activated potassium current known as the M-current. The M-current can be suppressed by various neurotransmitters that activate Gq-coupled receptors.
Naoto Hoshi, Naoto Hoshi
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Impact of Administration Time and Kv7 Subchannels on the Cardioprotective Efficacy of Kv7 Channel Inhibition [PDF]
Drug Design, Development and Therapy, 2020 Jan Hansen,1,2,* Jacob Johnsen,1,2,* Jan Møller Nielsen,1,2 Charlotte Brandt Sørensen,1,2 Casper Carlsen Elkjær,1,2 Nichlas Riise Jespersen,1,2 Hans Erik Bøtker1,2 1Department of Cardiology, Aarhus University Hospital, Aarhus ...
Hansen J +6 more
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Molecular expression and pharmacological evidence for a functional role of kv7 channel subtypes in Guinea pig urinary bladder smooth muscle. [PDF]
PLoS ONE, 2013 Voltage-gated Kv7 (KCNQ) channels are emerging as essential regulators of smooth muscle excitability and contractility. However, their physiological role in detrusor smooth muscle (DSM) remains to be elucidated. Here, we explored the molecular expression
Serge A Y Afeli +2 more
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From pan-reactive KV7 channel opener to subtype selective opener/inhibitor by addition of a methyl group. [PDF]
PLoS ONE, 2014 The voltage-gated potassium channels of the KV7 family (KV7.1-5) play important roles in controlling neuronal excitability and are therefore attractive targets for treatment of CNS disorders linked to hyperexcitability.
Sigrid Marie Blom +5 more
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KV7 channel activation inhibits human and murine myometrium contractility and delays delivery in a mouse model of preterm birth [PDF]
Communications MedicineBackground Spontaneous preterm birth, defined as delivery before 37 weeks of gestation, remains a global cause of neonatal illness and death, yet treatments for preterm labor remain limited.
Yosef T. Mansour +14 more
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Modulation of KV7 Channel Deactivation by PI(4,5)P2 [PDF]
Frontiers in Pharmacology, 2020 The activity of KV7 channels critically contributes to the regulation of cellular electrical excitability in many cell types. In the central nervous system, the heteromeric KV7.2/KV7.3 channel is thought to be the chief molecular entity giving rise to M ...
Carlos A. Villalba-Galea
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Kv7 Channels as an Important Contributor to Alcohol-Induced Modulation of Neuronal Excitability in Neonatal Rat Superior Cervical Ganglion [PDF]
CellsNormal alcohols (n-alcohols) exhibit contrasting effects on neuronal excitability; specifically, ethanol enhances neuronal firing, while hexanol suppresses it. Both compounds are known to inhibit sodium currents, yet the mechanisms behind their differing
Da-Jeong Jeong +4 more
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Site and Mechanism of ML252 Inhibition of Kv7 Voltage-Gated Potassium Channels
Function, 2023 Kv7 (KCNQ) voltage-gated potassium channels are critical regulators of neuronal excitability and are candidate targets for development of antiseizure medications.
Richard Kanyo +6 more
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