Results 31 to 40 of about 1,204,901 (187)
Chemical modulation of Kv7 potassium channels
RSC Medicinal Chemistry, 2021 This review describes the synthetic and medicinal chemistry of small molecule modulators of the voltage-gated Kv7 (KCNQ) potassium channels and the available data of their biological and clinical properties.
Matteo Borgini +3 more
openaire +3 more sources
Could NAPQI Contribute to Paracetamol Analgesia? Redox Modulation of Kv7 Ion Channels. [PDF]
Pharmacol Res PerspectABSTRACT Paracetamol (acetaminophen, APAP) is one of the most widely used analgesic and antipyretic drugs worldwide, yet its mechanism of action remains incompletely understood. While several pathways have been proposed, including cyclooxygenase inhibition and endocannabinoid modulation via AM404, none fully account for its pharmacological profile. The
M-Alicante S +6 more
europepmc +2 more sources
NeuralKCNQ(Kv7) channels [PDF]
British Journal of Pharmacology, 2009 KCNQgenes encode five Kv7 K+channel subunits (Kv7.1–Kv7.5). Four of these (Kv7.2–Kv7.5) are expressed in the nervous system. Kv7.2 and Kv7.3 are the principal molecular components of the slow voltage‐gated M‐channel, which widely regulates neuronal excitability, although other subunits may contribute to M‐like currents in some locations. M‐channels are
David A, Brown, Gayle M, Passmore
openaire +2 more sources
Journal of Pharmacological Sciences, 2021 Nicotine administration enhances object recognition memory. However, target brain regions and cellular mechanisms underlying the nicotine effects remain unclear.
Hirohito Esaki +5 more
doaj +1 more source
Zinc pyrithione activates K+ channels and hyperpolarizes the membrane of rat pulmonary artery smooth muscle cells. [PDF]
PLoS ONE, 2018 The membrane potential helps determine pulmonary artery smooth muscle cell (PASMC) contraction. The Kv7 channel activators, retigabine and flupirtine, are thought to dilate pulmonary arteries by hyperpolarising PASMC.
Basma G Eid, Alison M Gurney
doaj +1 more source
Modulation of Kv7 Channel Currents by Echinocystic Acid
Molecular Pharmacology, 2023 Modulation of KCNQ-encoded voltage-gated potassium Kv7/M channel function represents an attractive strategy to treat neuronal excitability disorders such as epilepsy, pain, and depression. The Kv7 channel group includes five subfamily members (Kv7.1-Kv7.5).
DanDan, Geng +7 more
openaire +2 more sources
Polyunsaturated Fatty Acids as Modulators of KV7 Channels
Frontiers in Physiology, 2020 Voltage-gated potassium channels of the KV7 family are expressed in many tissues. The physiological importance of KV7 channels is evident from specific forms of disorders linked to dysfunctional KV7 channels, including variants of epilepsy, cardiac ...
Johan E. Larsson +2 more
doaj +1 more source
Kv7 Channel Activation Underpins EPAC-Dependent Relaxations of Rat Arteries. [PDF]
Arterioscler Thromb Vasc Biol, 2016 OBJECTIVE: To establish the role of Kv7 channels in EPAC (exchange protein directly activated by cAMP)-dependent relaxations of the rat vasculature and to investigate whether this contributes to β-adrenoceptor-mediated vasorelaxations.
Stott JB, Barrese V, Greenwood IA.
europepmc +2 more sources
Analgesic Action of Acetaminophen via Kv7 Channels
International Journal of Molecular Sciences, 2022 The mechanism of acetaminophen (APAP) analgesia is at least partially unknown. Previously, we showed that the APAP metabolite N-acetyl-p-benzoquinone imine (NAPQI) activated Kv7 channels in neurons in vitro, and this activation of Kv7 channels dampened neuronal firing.
Jan-Luca Stampf +5 more
openaire +2 more sources
The contribution of Kv7 channels to pregnant mouse and human myometrial contractility. [PDF]
, 2011 Premature birth accounts for approximately 75% of neonatal mortality and morbidity in the developed world. Despite this, methods for identifying and treating women at risk of preterm labour are limited and many women still present in preterm labour ...
Pierce, SL +9 more
core +1 more source