Results 11 to 20 of about 1,204,901 (187)
Kv7 Channels in Lung Diseases [PDF]
Frontiers in Physiology, 2020 Lung diseases constitute a global health concern causing disability. According to WHO in 2016, respiratory diseases accounted for 24% of world population mortality, the second cause of death after cardiovascular diseases.
Gema Mondejar-Parreño +8 more
doaj +4 more sources
Kv7 and Kv11 channels in myometrial regulation. [PDF]
Experimental Physiology, 2013 Ion channels play a key role in defining myometrial contractility. Modulation of ion channel populations is proposed to underpin gestational changes in uterine contractility associated with the transition from uterine quiescence to active labour.
Tribe, Rachel M; id_orcid +5 more
core +6 more sources
Kv7 Channels and Excitability Disorders
, 2021 Kv7.1-Kv7.5 (KCNQ1–5) K+ channels are voltage-gated K+ channels with major roles in neurons, muscle cells and epithelia where they underlie physiologically important K+ currents, such as neuronal M current and cardiac IKs. Specific biophysical properties
Haixia Gao +5 more
core +4 more sources
Modulation of Kv7 channels and excitability in the brain [PDF]
Cellular and Molecular Life Sciences, 2017 Neuronal Kv7 channels underlie a voltage-gated non-inactivating potassium current known as the M-current. Due to its particular characteristics, Kv7 channels show pronounced control over the excitability of neurons.
Greene, Derek L, Hoshi, Naoto
core +6 more sources
Cyclic AMP-Dependent Regulation of Kv7 Voltage-Gated Potassium Channels [PDF]
Frontiers in Physiology, 2020 Voltage-gated Kv7 potassium channels, encoded by KCNQ genes, have major physiological impacts cardiac myocytes, neurons, epithelial cells, and smooth muscle cells. Cyclic adenosine monophosphate (cAMP), a well-known intracellular secondary messenger, can
Jennifer van der Horst +2 more
doaj +2 more sources
Inhibition of post-synaptic Kv7/KCNQ/M channels facilitates long-term potentiation in the hippocampus. [PDF]
PLoS ONE, 2012 Activation of muscarinic acetylcholine receptors (mAChR) facilitates the induction of synaptic plasticity and enhances cognitive function. In the hippocampus, M(1) mAChR on CA1 pyramidal cells inhibit both small conductance Ca(2+)-activated KCa2 ...
Milos M Petrovic +5 more
doaj +5 more sources
Vitamin D Receptor Deficiency Upregulates Pulmonary Artery Kv7 Channel Activity. [PDF]
Int J Mol Sci, 2023 Horizonte 2020. Marie-Curie Nº 847635.Recent evidence suggests that vitamin D is involved in the development of pulmonary arterial hypertension (PAH). The aim of this study was to analyze the electrophysiological and contractile properties of pulmonary ...
Olivencia MA +8 more
europepmc +3 more sources
PLoS ONE, 2015 The aim of the study was to investigate whether Kv7 channels and their ancillary β-subunits, KCNE, are functionally expressed in the human urinary bladder.
Julie Svalø +4 more
doaj +2 more sources
Structural Insight into KCNQ (Kv7) Channel Assembly and Channelopathy [PDF]
Neuron, 2007 SummaryKv7.x (KCNQ) voltage-gated potassium channels form the cardiac and auditory IKs current and the neuronal M-current. The five Kv7 subtypes have distinct assembly preferences encoded by a C-terminal cytoplasmic assembly domain, the A-domain Tail ...
Holton, James M. +3 more
core +4 more sources
Dehydroepiandrosterone Sulfate (DHEAS) Is an Endogenous Kv7 Channel Modulator That Reduces Kv7/M-Current Suppression and Inflammatory Pain. [PDF]
J Neurosci, 2023 Neuronal Kv7 voltage-gated potassium channels generate the M-current and regulate neuronal excitability. Here, we report that dehydroepiandrosterone sulfate (DHEAS) is an endogenous Kv7 channel modulator that attenuates Gq-coupled receptor-induced M ...
Alhassen L +6 more
europepmc +2 more sources