Inhibition of M/Kv7 Currents Contributes to Chloroquine-Induced Itch in Mice
Frontiers in Molecular Neuroscience, 2020 M/Kv7 potassium channels play a key role in regulation of neuronal excitability. Modulation of neuronal excitability of primary sensory neurons determines the itch sensation induced by a variety of itch-causing substances including chloroquine (CQ).
Dong Zhang +37 more
doaj +1 more source
The expression and function of KCNQ potassium channels in human chorionic plate arteries from women with normal pregnancies and pre-eclampsia. [PDF]
PLoS ONE, 2018 Pre-eclampsia is associated with altered maternal and placental vascular reactivity. Kv7 channels (encoded by KCNQ 1-5 genes) are a potential contributor to the regulation of vascular tone in CPAs (chorionic plate arteries) during normal pregnancy.
Xiaohong Wei +5 more
doaj +1 more source
Cycling matters: Sex hormone regulation of vascular potassium channels
Channels, 2023 Sex hormones and the reproductive cycle (estrus in rodents and menstrual in humans) have a known impact on arterial function. In spite of this, sex hormones and the estrus/menstrual cycle are often neglected experimental factors in vascular basic ...
Samuel N Baldwin +2 more
doaj +1 more source
The Journal of Clinical Investigation, 2023 Multiple sclerosis (MS) is a progressive inflammatory demyelinating disease of the CNS. Increasing evidence suggests that vulnerable neurons in MS exhibit fatal metabolic exhaustion over time, a phenomenon hypothesized to be caused by chronic ...
Hannah Kapell +41 more
doaj +1 more source
Detrusor Smooth Muscle KV7 Channels: Emerging New Regulators of Urinary Bladder Function
Frontiers in Physiology, 2020 Relaxation and contraction of the urinary bladder smooth muscle, also known as the detrusor smooth muscle (DSM), facilitate the micturition cycle. DSM contractility depends on cell excitability, which is established by the synchronized activity of ...
John Malysz +3 more
doaj +1 more source
Heterozygous Deletion of Epilepsy Gene KCNQ2 Has Negligible Effects on Learning and Memory
Frontiers in Behavioral Neuroscience, 2022 Neuronal Kv7/Potassium Voltage-Gated Channel Subfamily Q (KCNQ) potassium channels underlie M-current that potently suppresses repetitive and burst firing of action potentials (APs).
Gregory C. Tracy +7 more
doaj +1 more source
Heterogeneity in Kv7 channel function in the cerebral and coronary circulation. [PDF]
Microcirculation, 2015 AbstractObjectivesKv7 channels are considered important regulators of vascular smooth muscle contractility. The present study aimed to examine the hypotheses that (i) Kv7 channels are present in mouse cerebral and coronary arteries and regulate vascular reactivity and (ii) regional differences exist in the activity of these channels.Methods and ...
Lee S, Yang Y, Tanner MA, Li M, Hill MA.
europepmc +4 more sources
Vascular Kv7 channels control intracellular Ca2+ dynamics in smooth muscle [PDF]
, 2020 Voltage-gated Kv7 (or KCNQ) channels control activity of excitable cells, including vascular smooth muscle cells (VSMCs), by setting their resting membrane potential and controlling other excitability parameters. Excitation-contraction coupling in muscle
Mullen, P +13 more
core +2 more sources
The role of potassium channel activation in celecoxib-induced analgesic action. [PDF]
PLoS ONE, 2013 BACKGROUND AND PURPOSE: Celecoxib (CXB) is a widely prescribed COX-2 inhibitor used clinically to treat pain and inflammation. Recently, COX-2 independent mechanisms have been described to be the targets of CXB.
Yao Mi +8 more
doaj +1 more source
Activation of SGK1.1 Upregulates the M-current in the Presence of Epilepsy Mutations
Frontiers in Molecular Neuroscience, 2021 In the central nervous system, the M-current plays a critical role in regulating subthreshold electrical excitability of neurons, determining their firing properties and responsiveness to synaptic input.
Elva Martin-Batista +6 more
doaj +1 more source