Kv7 channels can function without constitutive calmodulin tethering.
PLoS ONE, 2011 M-channels are voltage-gated potassium channels composed of Kv7.2-7.5 subunits that serve as important regulators of neuronal excitability. Calmodulin binding is required for Kv7 channel function and mutations in Kv7.2 that disrupt calmodulin binding ...
Juan Camilo Gómez-Posada +11 more
doaj +7 more sources
Sexual dimorphisms in vascular KV7 channels [PDF]
Introduction: Kcnq-encoded KV7 channels (termed KV7.1-5) are essential regulators of vascular physiology and are associated with pathophysiological states, however, vascular studies on Kv7 channels to date have focussed almost solely on arteries from ...
Baldwin, S. N.
core +5 more sources
Potassium channel‐mediated NO‐induced vasodilation during maturation: Dominance of Kv7 channels
FASEB BioAdvancesMaturation represents a process characterized by adaptive changes, particularly in the circulatory system. However, it is not known whether, in neonates, potassium channels contribute to NO‐induced vasorelaxation at all and, if so, which potassium ...
Anastasia A. Shvetsova +4 more
doaj +4 more sources
Impaired Kv7 channel function in cerebral arteries of a tauopathy mouse model (rTg4510). [PDF]
Physiol Rep, 2018 In tauopathies, such as Alzheimer's disease with or without concomitant amyloid beta plaques, cerebral arteries display pathological remodeling, leading to reduced brain tissue oxygenation and cognitive impairment.
de Jong IEM, Jepps TA.
europepmc +2 more sources
Uncovered Contribution of Kv7 Channels to Pulmonary Vascular Tone in Pulmonary Arterial Hypertension [PDF]
, 2020 K+ channels play a fundamental role regulating membrane potential of pulmonary artery (PA) smooth muscle cells and their impairment is a common feature in pulmonary arterial hypertension (PAH).
Greenwood, Iain A. +11 more
core +3 more sources
Cannabidiol activates neuronal Kv7 channels
eLife, 2022 Cannabidiol (CBD), a chemical found in the Cannabis sativa plant, is a clinically effective antiepileptic drug whose mechanism of action is unknown. Using a fluorescence-based thallium flux assay, we performed a large-scale screen and found enhancement of flux through heterologously expressed
Sooyeon Jo +12 more
openaire +4 more sources
Identification of Sodium/Myo-Inositol Transporter 1 as a Major Determinant of Arterial Contractility. [PDF]
FASEB JThe tonicity‐responsive enhancer binding‐protein (TonEBP) and serum glucocorticoid kinase (SGK) sense a rise in extracellular hypertonicity resulting in an increase SMIT1 membrane abundance in vascular smooth muscle cells. SMIT1 associates with Kv7.4/5, Gβγ, and KCNE4, promoting hyperpolarization, reduced voltage‐gated calcium channel (VGCC) opening ...
Forrester EA +6 more
europepmc +2 more sources
A Calmodulin C-Lobe Ca2+-Dependent Switch Governs Kv7 Channel Function. [PDF]
Neuron, 2018 Kv7 (KCNQ) voltage-gated potassium channels control excitability in the brain, heart, and ear. Calmodulin (CaM) is crucial for Kv7 function, but how this calcium sensor affects activity has remained unclear.
Chang A +5 more
europepmc +2 more sources
The novel KV7 channel activator URO-K10 exerts enhanced pulmonary vascular effects independent of the KCNE4 regulatory subunit [PDF]
, 2023 KV7 channels exert a pivotal role regulating vascular tone in several vascular beds. In this context, KV7 channel agonists represent an attractive strategy for the treatment of pulmonary arterial hypertension (PAH).
Göcken Telli +55 more
core +1 more source
Restoration of Kv7 Channel-Mediated Inhibition Reduces Cued-Reinstatement of Cocaine Seeking. [PDF]
J Neurosci, 2018 Cocaine addicts display increased sensitivity to drug-associated cues, due in part to pathological changes in the prelimbic cortex (PL-PFC). The cellular mechanisms underlying cue-induced reinstatement of cocaine seeking remain unknown.
Parrilla-Carrero J +13 more
europepmc +2 more sources