Results 61 to 70 of about 1,204,901 (187)
Frontiers in Physiology, 2018 K+-channels of the Kv7/KCNQ-family hyperpolarize and stabilize excitable cells such as autonomic neurons and vascular smooth muscle cells (VSMC). Kv7 may therefore play a role in blood pressure (BP) homeostasis, and prevent a high total peripheral ...
Torill Berg
doaj +1 more source
Kcnv2 E151X Mouse Captures Hallmarks of KCNV2‐Associated Retinal Dystrophy
Clinical &Experimental Ophthalmology, EarlyView.ABSTRACT Background KCNV2‐associated retinopathy is a rare inherited retinal dystrophy caused by variants in the KCNV2 gene, leading to disrupted photoreceptor behaviour and progressive deterioration of vision. Patients have characteristic electroretinography abnormalities, including reduced cone response, delayed and reduced rod response to low light ...
Nermina Xhaferri +3 more
wiley +1 more source
, 2015 Aims Voltage-gated potassium channels encoded by KCNQ genes (Kv7 channels) are emerging as important regulators of vascular tone. In this study, we analysed the contribution of Kv7 channels to the vasodilation induced by hypoxia and the cyclic AMP ...
Jimenez, Rosario +13 more
core +1 more source
The M-Channel Blocker Linopirdine Is an Agonist of the Capsaicin Receptor TRPV1
Journal of Pharmacological Sciences, 2010 .: Linopirdine is a well known blocker of voltage-gated potassium channels from the Kv7 (or KCNQ) family that generate the so called M current in mammalian neurons.
Cristian Neacsu, Alexandru Babes
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The FEBS Journal, EarlyView.Repeated paclitaxel exposure causes long‐lasting nociceptor hyperexcitability and axonal retraction in adult sensory neurons. Using a long‐term primary nociceptor culture, we show that hyperexcitability is mediated by sequential upregulation of NaV1.8, TRPV1, TRPA1, and TRPM8 channels.
Angela Lamberti +3 more
wiley +1 more source
Kv7 channels: interaction with dopaminergic and serotonergic neurotransmission in the CNS
The Journal of Physiology, 2008 Neuronal Kv7 channels (also termed KCNQ channels) are the molecular correlate of the M‐current. The Kv7 channels activate at rather negative membrane potentials (≤ 60 mV), thereby ‘fine‐tuning’ the resting membrane potential. The Kv7 channels are widely expressed in the brain with the Kv7.2, Kv7.3 and Kv7.5 channels being the most abundant.
Hansen, H. +5 more
openaire +4 more sources
Frontiers in Physiology, 2020 Smooth muscle cells of the vasculature, viscera, and lungs generally express multiple α-subunits of the Kv7 voltage-gated potassium channel family, with increasing evidence that both Kv7.4 and Kv7.5 can conduct “M-currents” that are functionally ...
Lyubov I. Brueggemann +2 more
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Experimental Physiology, EarlyView.Abstract Balance and gaze rely on the rapid and accurate detection and signalling of head movements by vestibular type I and type II hair cells. Signal transduction and transmission involve several types of ion channels, which are acquired progressively during hair cell differentiation and whose identity is known only in part.
Giulia Cheli +9 more
wiley +1 more source
KV7 channels in the human detrusor: channel modulator effects and gene and protein expression
, 2017 Voltage-gated type 7 K+ (KV7 or KCNQ) channels regulate the contractility of various smooth muscles. With this study, we aimed to assess the role of KV7 channels in the regulation of human detrusor contractility, as well as the gene and protein ...
Mancuso, Cesare +5 more
core +1 more source
Implication of Kv7 Channels in the Spinal Antinociceptive Actions of Celecoxib [PDF]
The Journal of Pharmacology and Experimental Therapeutics, 2019 Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID) commonly used to treat pain conditions in humans. In addition to its blocking activity on cyclooxygenase (COX) enzymes, several other targets could contribute to its analgesic activity. Here we explore the spinal antinociceptive actions of celecoxib and the potential implication of Kv7 channels
Vicente Baz, Jorge +2 more
openaire +3 more sources