Results 81 to 90 of about 1,204,901 (187)

Functional significance of axonal Kv7 channels in hippocampal pyramidal neurons [PDF]

Proceedings of the National Academy of Sciences, 2008
Members of the Kv7 family (Kv7.2–Kv7.5) generate a subthreshold K + current, the M− current. This regulates the excitability of many peripheral and central neurons. Recent evidence shows that Kv7.2 and Kv7.3 subunits are targeted to the axon initial segment of hippocampal neurons by ...
Shah MM, Migliore M, Valencia I, Cooper EC, Brown DA   +4 more
openaire   +4 more sources

Loose–patch recordings reveal differential Kv7-dependent effects on spontaneous excitatory activity in control and epileptic CA1

Frontiers in Neurology
IntroductionThe non-inactivating potassium channels Kv7.2 and Kv7.3 contribute to the neuronal resting membrane potential and regulate neuronal excitability.
Ella Marie Nissen, Timo Kirschstein, Timo Kirschstein, Astrid Bertsche, Rüdiger Köhling, Rüdiger Köhling, Denise Franz, Denise Franz   +7 more
doaj   +1 more source

Ganoderic Acid A Ameliorates Pentylenetetrazol‐Induced Epilepsy in Mice via Activating KCNQ2

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
GA‐A binds and activates KCNQ2, thereby reducing epileptic‐like EEG discharges, the loss and apoptosis of hippocampal neurons, and improving anxiety and depression‐like behavioral changes. In addition, GA‐A inhibits neuroinflammation and alleviates oxidative stress independent of activating KCNQ2.
Yang Yao, Zhujun Liu, Xujiao Wang, Cunhao Bian, Rui Wang, Yukun Zhang   +5 more
wiley   +1 more source

The impact of hyperpolarization-activated cyclic nucleotide-gated (HCN) and voltage-gated potassium KCNQ/Kv7 channels on primary microglia function

Journal of Neuroinflammation, 2020
Background Microglia are essential to maintain cell homeostasis in the healthy brain and are activated after brain injury. Upon activation, microglia polarize towards different phenotypes.
Sabine Ulrike Vay, Lea Jessica Flitsch, Monika Rabenstein, Helena Monière, Igor Jakovcevski, Pavle Andjus, Dunja Bijelic, Stefan Blaschke, Helene Luise Walter, Gereon Rudolf Fink, Michael Schroeter, Maria Adele Rueger   +11 more
doaj   +1 more source

Functional screen for subtype specificity of voltage sensor–targeted Kv7 potentiators

British Journal of Pharmacology, Volume 183, Issue 17, Page 5372-5388, September 2026.
Background and Purpose Voltage‐gated Kv7 (potassium channel subfamily Q [KCNQ]) potassium channels are powerful modulators of neuronal excitability. ICA‐069673 is a N‐aryl benzamide drug that targets the voltage‐sensing domain (VSD) of Kv7.2 with strong selectivity over Kv7.3 or Kv7.5, but the molecular basis of this selectivity remains poorly ...
Richard Kanyo, Thomas M. Hammond, Alice W. Wang, Caroline K. Wang, Varun Aggarwal, Shawn M. Lamothe, Harley T. Kurata   +6 more
wiley   +1 more source

XE991 Reverses Enhanced Short-Term Plasticity in Rat Epileptic CA1

Brain Sciences
Background/Objectives: Recent evidence has suggested a transcriptional reduction in Kv7 potassium channels in the CA1 area of acquired experimental epilepsy, but presynaptic Kv7 channels might be spared.
Emma Schnell, Steffen Müller, Rüdiger Köhling, Timo Kirschstein   +3 more
doaj   +1 more source

The acrylamide (S)-2 as a positive and negative modulator of Kv7 channels expressed in Xenopus laevis oocytes. [PDF]

PLoS ONE, 2009
BACKGROUND: Activation of voltage-gated potassium channels of the Kv7 (KCNQ) family reduces cellular excitability. These channels are therefore attractive targets for treatment of diseases characterized by hyperexcitability, such as epilepsy, migraine ...
Sigrid Marie Blom, Nicole Schmitt, Henrik Sindal Jensen   +2 more
doaj   +1 more source

Astrocytes in Genetic Epilepsies: Supporting Actor or Key Player?

Journal of Neuroscience Research, Volume 104, Issue 8, August 2026.
Astrocytes contribute to the pathophysiology of acquired epilepsy. However, less is known about their contribution to genetic epilepsy syndromes which often exhibit frequent comorbidity with neurodevelopmental and psychiatric disorders. Epileptic seizures are also frequently present in neurodevelopmental disorders.
Jenny Lange, Erica Zhao, Ellie O'Connell, Olivia Gillham, Amy McTague   +4 more
wiley   +1 more source

Phosphorylation of Kv7 Channels Regulates their PIP2 Sensitivity [PDF]

Biophysical Journal, 2015
Kv7 channels are a subfamily of voltage-gated K+ channels that play a major role in the regulation of neuronal excitability. One important factor in the function of these channels is PIP2, which is required for gating. GPCRs govern Kv7 channels by determining the levels of PIP2, on one hand, and via phosphorylation on the other hand.
Erdem, Fatma Asli, Salzer, Isabella, Chen, Wei-Qiang, Lubec, Gert, Shapiro, Mark S., Boehm, Stefan, Yang, Jae-Won   +6 more
openaire   +1 more source

Gβγ subunit activation of KV7 and BKCa channels underlies calcitonin gene‐related peptide vasorelaxation in myogenic rat coronary resistance arteries

British Journal of Pharmacology, Volume 183, Issue 16, Page 5018-5032, August 2026.
Abstract Background and Purpose CGRP is a potent, clinically relevant coronary vasodilator known to play a role in cardioprotection. Here, we investigated the precise intracellular signalling pathways leading to vasodilation in small coronary arteries.
Lucy A. Donovan, JinHeng Lin, Milind Khashu, Christopher J. Garland, Kim A. Dora   +4 more
wiley   +1 more source