Results 51 to 60 of about 1,204,901 (187)
, 2020 Retigabine is unique among anticonvulsant drugs by targeting the neuronal M-channel, which is composed of KV7.2/KV7.3 and contributes to the negative neuronal resting membrane potential.
Wu, Xiongyu +7 more
core +1 more source
Frontiers in Pharmacology, 2023 Chronic pain is highly prevalent and remains a significant unmet global medical need. As part of a search for modulatory genes that confer pain resilience, we have studied two family cohorts where one individual reported much less pain than other family ...
Mark Estacion +9 more
doaj +1 more source
Journal of Pharmacological Sciences, 2015 Kynurenine is a potential contributor to hypotension in animal and human sepsis. The present study was designed to examine whether the voltage-dependent K+ channels encoded by the KCNQ gene family (Kv7 channels) mediate vasodilator effects of kynurenine ...
Kensuke Sakakibara +8 more
doaj +1 more source
The C‐terminus of Kv7 channels: a multifunctional module
The Journal of Physiology, 2008 Kv7 channels (KCNQ) represent a family of voltage‐gated K+ channels which plays a prominent role in brain and cardiac excitability. Their physiological importance is underscored by the existence of mutations in human Kv7 genes, leading to severe cardiovascular and neurological disorders such as the cardiac long QT syndrome and neonatal epilepsy.
Yoni, Haitin, Bernard, Attali
openaire +3 more sources
Kv7 Channels in Cyclic-Nucleotide Dependent Relaxation of Rat Intra-Pulmonary Artery
Biomolecules, 2022 Pulmonary hypertension is treated with drugs that stimulate cGMP or cAMP signalling. Both nucleotides can activate Kv7 channels, leading to smooth muscle hyperpolarisation, reduced Ca2+ influx and relaxation.
Mohammed Al-Chawishly +2 more
doaj +1 more source
Molecular Basis for Activation to Inhibition Switching in Kv7.2 Channel Modulators
Angewandte Chemie International Edition, EarlyView.The paper describes the serendipitous discovery of chemical manipulation allowing the activator‐to‐inhibitor switching in Kv7.2 channel modulators. The molecular determinants driving this switch have been rationalized by multidisciplinary investigation encompassing synthetic and analytical chemistry, in silico methods, cryo‐EM analysis ...
Tania Ciaglia +20 more
wiley +1 more source
Targeting Kv7 Potassium Channels for Epilepsy
CNS DrugsVoltage-gated Kv7 potassium channels, particularly Kv7.2 and Kv.7.3 channels, play a critical role in modulating susceptibility to seizures, and mutations in genes that encode these channels cause heterogeneous epilepsy phenotypes. On the basis of this evidence, activation of Kv7.2 and Kv.7.3 channels has long been considered an attractive target in ...
Emilio Perucca, Maurizio Taglialatela
openaire +3 more sources
British Journal of Pharmacology, EarlyView.Obesity is a chronic, relapsing, multisystem disease in which cardiometabolic risk arises from excess adiposity and progressive dysfunction of peripheral organs, ultimately disrupting endocrine and metabolic crosstalk among tissues. Within this network, sulphur‐based biology, centred on hydrogen sulphide and related reactive sulphur species, has ...
Martina Smimmo +4 more
wiley +1 more source
Protein expression of Kv7 channel subtypes in guinea pig DSM.
, 2013 Confocal images illustrate the staining for Kv7.1 (A), Kv7.2 (B), Kv7.3 (C), Kv7.4 (D), and Kv7.5 (E) channel subtype proteins in mucosa-free whole DSM tissue.
Serge A. Y. Afeli (431004) +2 more
core +1 more source
Kv7 channel antagonists block glycine receptors [PDF]
, 2022 Abstract XE991 (10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone) is currently the most widely used and specific antagonist of the Kv7 (KCNQ) family of K + channels. We report an unexpected antagonistic effect of this drug on ionotropic glycine receptors.
Hsin-Wei Lu +4 more
openaire +1 more source