Results 51 to 60 of about 799,860 (178)

Site and Mechanism of ML252 Inhibition of Kv7 Voltage-Gated Potassium Channels

Function, 2023
Kv7 (KCNQ) voltage-gated potassium channels are critical regulators of neuronal excitability and are candidate targets for development of antiseizure medications.
Richard Kanyo, Shawn M Lamothe, Arturo Urrutia, Samuel J Goodchild, W Ted Allison, Richard Dean, Harley T Kurata   +6 more
doaj   +1 more source

Nicotine enhances object recognition memory through inhibition of voltage-dependent potassium 7 channels in the medial prefrontal cortex of mice

Journal of Pharmacological Sciences, 2021
Nicotine administration enhances object recognition memory. However, target brain regions and cellular mechanisms underlying the nicotine effects remain unclear.
Hirohito Esaki, Shoma Izumi, Akari Fukao, Naoya Nishitani, Satoshi Deyama, Katsuyuki Kaneda   +5 more
doaj   +1 more source

KCNQ channels regulate age-related memory impairment:KCNQ regulates age-related memory [PDF]

, 2013
In humans KCNQ2/3 heteromeric channels form an M-current that acts as a brake on neuronal excitability, with mutations causing a form of epilepsy. The M-current has been shown to be a key regulator of neuronal plasticity underlying associative memory and
Bilal R Malik, Malik, Bilal R., Cavaliere, Sonia, Malik, Bilal R, Bilal R. Malik (408687), James J. L. Hodge, Sonia Cavaliere, James J. L. Hodge (116854), Bilal R. Malik, Hodge, James J. L., James J L Hodge, Sonia Cavaliere (116850), Hodge, James J L   +12 more
core   +1 more source

Neuron populations use variable combinations of short-term feedback mechanisms to stabilize firing rate.

PLoS Biology, 2023
Neurons tightly regulate firing rate and a failure to do so leads to multiple neurological disorders. Therefore, a fundamental question in neuroscience is how neurons produce reliable activity patterns for decades to generate behavior. Neurons have built-
Sarah Pellizzari, Min Hu, Lara Amaral-Silva, Sandy E Saunders, Joseph M Santin   +4 more
doaj   +1 more source

Structural Insight into KCNQ (Kv7) Channel Assembly and Channelopathy [PDF]

Neuron, 2007
Kv7.x (KCNQ) voltage-gated potassium channels form the cardiac and auditory I(Ks) current and the neuronal M-current. The five Kv7 subtypes have distinct assembly preferences encoded by a C-terminal cytoplasmic assembly domain, the A-domain Tail.
Howard, Rebecca J., Clark, Kimberly A., Holton, James M., Minor, Daniel L.   +3 more
openaire   +2 more sources

Role and Mechanism of Polyunsaturated Fatty Acids on Potassium Ion Channels

Shengwu huaxue yu shengwu wuli jinzhan
Polyunsaturated fatty acids (PUFAs) have diverse health-promoting effects, such as potentially protecting in immune, nervous, and cardiovascular systems by targeting a variety of sites, including most ion channels. Voltage-gated potassium channels of the
SUN Yu-Jiao, CHANG Chao, WU Zhen-Hua, ZHANG Yi-Fei, TIAN Yu-Tao   +4 more
doaj   +1 more source

Zinc pyrithione activates K+ channels and hyperpolarizes the membrane of rat pulmonary artery smooth muscle cells. [PDF]

PLoS ONE, 2018
The membrane potential helps determine pulmonary artery smooth muscle cell (PASMC) contraction. The Kv7 channel activators, retigabine and flupirtine, are thought to dilate pulmonary arteries by hyperpolarising PASMC.
Basma G Eid, Alison M Gurney
doaj   +1 more source

Kv7 channels critically determine coronary artery reactivity: left-right differences and down-regulation by hyperglycaemia

, 2015
Aims Voltage-gated potassium channels encoded by KCNQ genes (Kv7 channels) are emerging as important regulators of vascular tone. In this study, we analysed the contribution of Kv7 channels to the vasodilation induced by hypoxia and the cyclic AMP ...
Jimenez, Rosario, Morales-Cano, Daniel, Duarte, Juan, Morales Cano, Daniel, Barreira, Bianca, Cogolludo Torralba, Ángel Luis, Cogolludo, Angel, Moreno, Laura, Moreno Gutiérrez, Laura, Pérez Vizcaíno, Francisco, Pandolfi, Rachele, Chamorro, Virginia, Villamor, Eduardo, Perez-Vizcaino, Francisco   +13 more
core   +1 more source

Kv7(KCNQ)-K+-Channels Influence Total Peripheral Resistance in Female but Not Male Rats, and Hamper Catecholamine Release in Hypertensive Rats of Both Sexes

Frontiers in Physiology, 2018
K+-channels of the Kv7/KCNQ-family hyperpolarize and stabilize excitable cells such as autonomic neurons and vascular smooth muscle cells (VSMC). Kv7 may therefore play a role in blood pressure (BP) homeostasis, and prevent a high total peripheral ...
Torill Berg
doaj   +1 more source

The C‐terminus of Kv7 channels: a multifunctional module

The Journal of Physiology, 2008
Kv7 channels (KCNQ) represent a family of voltage‐gated K+ channels which plays a prominent role in brain and cardiac excitability. Their physiological importance is underscored by the existence of mutations in human Kv7 genes, leading to severe cardiovascular and neurological disorders such as the cardiac long QT syndrome and neonatal epilepsy.
Yoni, Haitin, Bernard, Attali
openaire   +3 more sources