Kv7 channels are upregulated during striatal neuron development and promote maturation of human iPSC-derived neurons. [PDF]
Pflugers Arch, 2018 \ua9 2018 The Author(s)Kv7 channels determine the resting membrane potential of neurons and regulate their excitability. Even though dysfunction of Kv7 channels has been linked to several debilitating childhood neuronal disorders, the ontogeny of the ...
Telezhkin V +14 more
europepmc +4 more sources
Rapid activity-dependent modulation of the intrinsic excitability through up-regulation of KCNQ/Kv7 channel function in neonatal spinal motoneurons. [PDF]
PLoS ONE, 2018 Activity-dependent changes in the properties of the motor system underlie the necessary adjustments in its responsiveness on the basis of the environmental and developmental demands of the organism.
Joseph Lombardo +2 more
doaj +1 more source
, 2014 The medial entorhinal cortex (MEC) is important for spatial navigation and memory. Stellate cells (SCs) of MEC layer II provide major input to the hippocampus, and are thought to be the neuronal correlate of the grid cells.
Storm, Johan F. +2 more
core +1 more source
Implication of Kv7 Channels in the Spinal Antinociceptive Actions of Celecoxib [PDF]
The Journal of Pharmacology and Experimental Therapeutics, 2019 Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID) commonly used to treat pain conditions in humans. In addition to its blocking activity on cyclooxygenase (COX) enzymes, several other targets could contribute to its analgesic activity. Here we explore the spinal antinociceptive actions of celecoxib and the potential implication of Kv7 channels
Vicente Baz, Jorge +2 more
openaire +3 more sources
Calcium‐activated chloride channels in pericytes and their role in regulating organ blood flow
The Journal of Physiology, EarlyView.Abstract figure legend Pericytes are microvascular mural cells with diverse roles. Contractile pericytes directly regulate local perfusion, while non‐contractile pericytes coordinate upstream vascular contractility via propagating electrical signals.
Paolo Tammaro, Hikaru Hashitani
wiley +1 more source
Maturation of spinal motor control through developmental changes in ion currents
The Journal of Physiology, EarlyView.Abstract figure legend Ion channels of spinal neurons have been shown to change during development in a wide range of species. These changes occur at specific stages of development. An important developmental process is the maturation of motor control by which the body acquires new movements or refines movements already present.
Stephanie F. Gaudreau, Tuan V. Bui
wiley +1 more source
ET-CORM Mediated Vasorelaxation of Small Mesenteric Arteries: Involvement of Kv7 Potassium Channels
Frontiers in Pharmacology, 2021 Although the vasoactive properties of carbon monoxide (CO) have been extensively studied, the mechanism by which CO mediates vasodilation is not completely understood.
Danfeng Zhang +8 more
doaj +1 more source
British Journal of Pharmacology, Volume 183, Issue 20, Page 6179-6198, October 2026.Background and Purpose Episodic ataxia type 1 (EA1) is an autosomal dominant neurological disorder caused primarily by loss‐of‐function mutations in the voltage‐gated potassium channel Kv1.1 (KCNA1). Small molecules that restore Kv1.1 activity hold promise as targeted therapies for EA1, yet current pharmacological strategies remain limited ...
Rían W. Manville +6 more
wiley +1 more source
Molecular expression and pharmacological evidence for a functional role of kv7 channel subtypes in Guinea pig urinary bladder smooth muscle. [PDF]
PLoS ONE, 2013 Voltage-gated Kv7 (KCNQ) channels are emerging as essential regulators of smooth muscle excitability and contractility. However, their physiological role in detrusor smooth muscle (DSM) remains to be elucidated. Here, we explored the molecular expression
Serge A Y Afeli +2 more
doaj +1 more source
Role of the C-terminal domain in the structure and function of tetrameric sodium channels [PDF]
, 2013 Voltage-gated sodium channels have essential roles in electrical signalling. Prokaryotic sodium channels are tetramers consisting of transmembrane (TM) voltage-sensing and pore domains, and a cytoplasmic carboxy-terminal domain.
Clapham, D.E. +17 more
core +2 more sources