Results 91 to 100 of about 799,860 (178)
Functional screen for subtype specificity of voltage sensor–targeted Kv7 potentiators
British Journal of Pharmacology, Volume 183, Issue 17, Page 5372-5388, September 2026.Background and Purpose Voltage‐gated Kv7 (potassium channel subfamily Q [KCNQ]) potassium channels are powerful modulators of neuronal excitability. ICA‐069673 is a N‐aryl benzamide drug that targets the voltage‐sensing domain (VSD) of Kv7.2 with strong selectivity over Kv7.3 or Kv7.5, but the molecular basis of this selectivity remains poorly ...
Richard Kanyo +6 more
wiley +1 more source
, 2023 KCNQ channels, also known as Kv7 channels, are a diverse group of K+ channels that exhibit a wide variety of properties and perform various physiological functions in the body. This family comprises five members, Kv7.1-7.5. These channels exhibit unusual
Tzingounis, Anastasios V. +1 more
core +1 more source
Identifying KIF Subtype that Mediates Axonal Targeting of Kv7 Channels [PDF]
, 2018 Early-onset Benign Familial Neonatal Epilepsy (BFNE) and Epileptic Encephalopathy (EE), are associated with mutations in neuronal KCNQ/Kv7 channel subunits Kv7.2 and Kv7.3. Kv7 channels are voltage-dependent potassium channels.
Chung, Hee Jung +4 more
core
Phosphorylation of Kv7 Channels Regulates their PIP2 Sensitivity [PDF]
Biophysical Journal, 2015 Kv7 channels are a subfamily of voltage-gated K+ channels that play a major role in the regulation of neuronal excitability. One important factor in the function of these channels is PIP2, which is required for gating. GPCRs govern Kv7 channels by determining the levels of PIP2, on one hand, and via phosphorylation on the other hand.
Erdem, Fatma Asli +6 more
openaire +1 more source
Astrocytes in Genetic Epilepsies: Supporting Actor or Key Player?
Journal of Neuroscience Research, Volume 104, Issue 8, August 2026.Astrocytes contribute to the pathophysiology of acquired epilepsy. However, less is known about their contribution to genetic epilepsy syndromes which often exhibit frequent comorbidity with neurodevelopmental and psychiatric disorders. Epileptic seizures are also frequently present in neurodevelopmental disorders.
Jenny Lange +4 more
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 16, Page 5018-5032, August 2026.Abstract Background and Purpose CGRP is a potent, clinically relevant coronary vasodilator known to play a role in cardioprotection. Here, we investigated the precise intracellular signalling pathways leading to vasodilation in small coronary arteries.
Lucy A. Donovan +4 more
wiley +1 more source
Kv7 (KCNQ) potassium channels that are mutated in human diseases [PDF]
The Journal of Physiology, 2008 Kv7 channels are a small family of voltage-gated potassium channel subunits (Kv7.1–Kv7.5) that are encoded by the KCNQ genes (KCNQ1–5) (reviewed by Jentsch, 2000; and by Robbins, 2001). Structurally, they resemble other Kv channels, with six transmembrane domains, a voltage sensor in the fourth (S4) domain, and a pore loop between the S5 and S6 domains,
openaire +2 more sources
CaV1.2 dynamics in native male arterial myocytes
The Journal of Physiology, Volume 604, Issue 15, Page 6302-6323, 1 August 2026.Abstract figure legend Proposed model of microtubule‐dependent CaV1.2 reorganization in vascular disease. Schematic illustration of microtubule‐mediated delivery and stabilization of CaV1.2 channels into enlarged plasma membrane clusters in response to Ang II or hyperglycaemia, promoting cooperative gating and enhanced Ca2+ influx. Abstract L‐type CaV1.
Miguel Martin‐Aragon Baudel +9 more
wiley +1 more source
Archiv der Pharmazie, Volume 359, Issue 7, July 2026.Loss‐of‐function mutations of the voltage‐gated potassium channel KV7.1 (KCNQ1) can lead to malignant arrhythmia. The effects of five 1,4‐benzodiazepines modified at the lactam on KV7.1 gating were thoroughly analysed by two‐electrode voltage clamp experiments.
Florian Roßner +5 more
wiley +1 more source
Role of Kv7 channels in responses of the pulmonary circulation to hypoxia
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2015 Hypoxic pulmonary vasoconstriction (HPV) is a beneficial mechanism that diverts blood from hypoxic alveoli to better ventilated areas of the lung, but breathing hypoxic air causes the pulmonary circulation to become hypertensive. Responses to airway hypoxia are associated with depolarization of smooth muscle cells in the pulmonary arteries and reduced ...
Sedivy, V +8 more
openaire +2 more sources