Epilepsy: Epidemiology, Molecular Pathogenesis, and Clinical Management
MedComm, Volume 7, Issue 7, July 2026.Epilepsy is a heterogeneous and chronically evolving brain network disorder. This review integrates epidemiological burden, psychiatric comorbidities, and cyclic seizure patterns with multiscale pathogenic mechanisms, including ion‐channel dysfunction, synaptic transmission defects, neuroinflammation, metabolic and mitochondrial dysfunction, and ...
Jian Liu +8 more
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Investigations on subunit-specific assembly and structure-function studies of the voltage sensor in KCNQ potassium channels [PDF]
, 2007 A detailed understanding of how potassium channels function is crucial e. g. for the development of drugs, which could lead to novel therapeutic concepts for diseases ranging from diabetes to cardiac abnormalities.
Athanasiadu, Despina, Athanasiadu, D.
core
The M-Channel Blocker Linopirdine Is an Agonist of the Capsaicin Receptor TRPV1
Journal of Pharmacological Sciences, 2010 .: Linopirdine is a well known blocker of voltage-gated potassium channels from the Kv7 (or KCNQ) family that generate the so called M current in mammalian neurons.
Cristian Neacsu, Alexandru Babes
doaj +1 more source
Skeletal muscle Kv7 (KCNQ) channels in myoblast differentiation and proliferation
, 2008 Voltage-dependent K+ channels (Kv) are involved in myocyte proliferation and differentiation by triggering changes in membrane potential and regulating cell volume.
Felipe, Antonio +4 more
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Kv7 K+ Channels in Airway Smooth Muscle Cells as Target for Asthma Therapy [PDF]
, 2012 Airway hyperresponsiveness (AHR) is an important etiological feature of asthma, the molecular mechanisms of which are poorly understood, thus preventing development of specific and effective therapies.
Kakad, Priyanka Prakash
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Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley +1 more source
Redox regulation of KV7 channels through EF3 hand of calmodulin. [PDF]
Elife, 2023 Nuñez E +10 more
europepmc +1 more source
Targeting 5-HT<sub>2A</sub> receptors and Kv7 channels in PFC to attenuate chronic neuropathic pain in rats using a spared nerve injury model. [PDF]
Neurosci Lett, 2022 Vizcarra VS +8 more
europepmc +1 more source
Activation of KV7 channels stimulates vasodilatation of human placental chorionic plate arteries.
, 2015 Introduction: Potassium (K(+)) channels are key regulators of vascular smooth muscle cell (VSMC) excitability. In systemic small arteries, Kv7 channel expression/activity has been noted and a role in vascular tone regulation demonstrated.
Robinson, M +11 more
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Translational PsychiatryThe voltage-gated Kv7/KCNQ/M potassium channels exert inhibitory control over neuronal membrane excitability. The reduction of Kv7 channel function can improve neuronal excitability that defines the fundamental mechanism of learning and memory.
Huan Shi +4 more
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