Results 111 to 120 of about 799,860 (178)

KV7 channels in the human detrusor: channel modulator effects and gene and protein expression

, 2017
Voltage-gated type 7 K+ (KV7 or KCNQ) channels regulate the contractility of various smooth muscles. With this study, we aimed to assess the role of KV7 channels in the regulation of human detrusor contractility, as well as the gene and protein ...
Mancuso, Cesare, Martire, Maria, Curro', Diego, Bientinesi, Riccardo, Bassi, Pierfrancesco, Sacco, Emilio   +5 more
core   +1 more source

Vascular Kv7 (KCNQ) Potassium Channels As Therapeutic Targets in Cerebral Vasospasm [PDF]

, 2012
Cerebral vasospasm, a grave sequel to subarachnoid hemorrhage (SAH), is characterized by prolonged severe constriction of arteries in the base of the brain, including the basilar artery.
Mani, Bharath Kumar
core   +1 more source

Participation of calcium-permeable AMPA receptors in the regulation of epileptiform activity of hippocampal neurons

Frontiers in Synaptic Neuroscience
IntroductionEpileptiform activity is the most striking result of hyperexcitation of a group of neurons that can occur in different brain regions and then spread to other sites.
Valery Petrovich Zinchenko, Ilia Yu. Teplov, Artem Mikhailovich Kosenkov, Sergei Gennadievich Gaidin, Bakytzhan Kairatuly Kairat, Sultan Tuleukhanovich Tuleukhanov   +5 more
doaj   +1 more source

Voltage-gated Potassium Channels (Kv7): Molecular Structure, Regulation, and Role in Pathogenesis

Engineered Science
The potassium channels of the Kv7 family, comprising KCNQ1 to KCNQ5, assume a critical role in the regulation of membrane potential and cellular excitability within the nervous, cardiovascular, sensory, and endocrine systems.
Gulmira Tussupbekova
doaj   +1 more source

KV7 channels regulate muscle tone and nonadrenergic noncholinergic relaxation of the rat gastric fundus

, 2011
Voltage-dependent type 7 K+ (KV7) channels play important physiological roles in neurons and muscle cells. The aims of the present study were to investigate the motor effects of KV7 channel modulators in the rat gastric fundus and the expression of KV7
TAGLIALATELA, MAURIZIO, Currò, D., Martire, Maria, M. Taglialatela, Ipavec, V, V. Ipavec, Curro', Diego, V. Barrese, D. Currò, Martire, M, Barrese, V, M. Martire   +11 more
core   +1 more source

Vascular Kv7 channels control intracellular Ca2+ dynamics in smooth muscle

, 2020
Voltage-gated Kv7 (or KCNQ) channels control activity of excitable cells, including vascular smooth muscle cells (VSMCs), by setting their resting membrane potential and controlling other excitability parameters. Excitation-contraction coupling in muscle
Pierce Mullen (14334441), Nikita Gamper (8144328), Chris Peers (105625), Karen E Porter (24036300), Derek Steele (15450525), Frederick Jones (23876856), Yuan-Ming Tsai (17145941)   +6 more
core  

Autism-associated mutations in K_V7 channels induce gating pore current. [PDF]

Proc Natl Acad Sci U S A, 2021
Gamal El-Din TM, Lantin T, Tschumi CW, Juarez B, Quinlan M, Hayano JH, Li J, Zweifel LS, Catterall WA.   +8 more
europepmc   +1 more source

Physiological and pharmacological modulation of Kv7 channels

, 2017
Voltage-dependent potassium channels are spanning-membrane integral proteins involved in several and diverse physiological and pathological processes such as immune response or cardiovascular function. The first goal of this study was to elucidate the role of KV7.1/KV7.5, as a heterotetramer complex, in vascular smooth muscle.
openaire   +3 more sources

Pharmacological approaches in drug-resistant pediatric epilepsies caused by pathogenic variants in potassium channel genes

Frontiers in Cellular Neuroscience
Variants in genes encoding for voltage-gated K+ (Kv) channels are frequent cause of drug-resistant pediatric epilepsies. Obtaining a molecular diagnosis gives the opportunity to assess the efficacy of pharmacological strategies based on in vitro features
Ilaria Filareto, Ilaria Mosca, Elena Freri, Francesca Ragona, Laura Canafoglia, Roberta Solazzi, Barbara Castellotti, Giuliana Messina, Cinzia Gellera, Maria Virginia Soldovieri, Paolo Ambrosino, Maurizio Taglialatela, Jacopo C. DiFrancesco, Tiziana Granata   +13 more
doaj   +1 more source

Chemical regulation of Kv7 channels: Diverse scaffolds, sites, and mechanisms of action. [PDF]

J Gen Physiol, 2020
Kurata HT.
europepmc   +1 more source