Results 81 to 90 of about 799,860 (178)

Polyunsaturated Fatty acids as Kv7 Channel Modulators [PDF]

Biophysical Journal, 2013
Lipids in different forms can directly affect the electric activity of excitable tissues, in some cases via direct interactions with ion channels. For instance is the activity of Kv7 (KCNQ) channels dependent on the abundance of the phospholipid PIP2 in the inner leaflet of the plasma membrane.
Liin, Sara I., Schmitt, Nicole, Bentzen, Bo H., Elinder, Fredrik   +3 more
openaire   +1 more source

Multi‐omics analysis of ion channels expressed by chicken embryo vestibular type I and type II hair cells

Experimental Physiology, Volume 111, Issue 10, Page 4894-4914, 1 October 2026.
Abstract Balance and gaze rely on the rapid and accurate detection and signalling of head movements by vestibular type I and type II hair cells. Signal transduction and transmission involve several types of ion channels, which are acquired progressively during hair cell differentiation and whose identity is known only in part.
Giulia Cheli, Roberta Giunta, Francesca Stella, Eleonora Guidi, Umberto Laforenza, Mariarosa Polimeni, Giancarlo Russo, Francesca Borgo, Lazarevic Dejan, Sergio Masetto   +9 more
wiley   +1 more source

Inhibition of M/Kv7 Currents Contributes to Chloroquine-Induced Itch in Mice

Frontiers in Molecular Neuroscience, 2020
M/Kv7 potassium channels play a key role in regulation of neuronal excitability. Modulation of neuronal excitability of primary sensory neurons determines the itch sensation induced by a variety of itch-causing substances including chloroquine (CQ).
Dong Zhang, Dong Zhang, Dong Zhang, Dong Zhang, Dong Zhang, Hongchao Men, Hongchao Men, Hongchao Men, Hongchao Men, Hongchao Men, Ludi Zhang, Ludi Zhang, Ludi Zhang, Ludi Zhang, Xiangxin Gao, Xiangxin Gao, Xiangxin Gao, Xiangxin Gao, Jingjing Wang, Jingjing Wang, Jingjing Wang, Jingjing Wang, Leying Li, Leying Li, Leying Li, Leying Li, Qiaoying Zhu, Qiaoying Zhu, Qiaoying Zhu, Qiaoying Zhu, Hailin Zhang, Hailin Zhang, Hailin Zhang, Hailin Zhang, Zhanfeng Jia, Zhanfeng Jia, Zhanfeng Jia, Zhanfeng Jia   +37 more
doaj   +1 more source

The Natural Plant Product Rottlerin Activates Kv7.1/KCNE1 Channels

Cellular Physiology and Biochemistry, 2016
Background/Aims: Acquired as well as inherited channelopathies are disorders that are caused by altered ion channel function. A family of channels whose malfunction is associated with different channelopathies is the Kv7 K+ channel family; and ...
Veronika Matschke, Ilaria Piccini, Janina Schubert, Eva Wrobel, Florian Lang, Johann Matschke, Elsie Amedonu, Sven G. Meuth, Timo Strünker, Nathalie Strutz-Seebohm, Boris Greber, Jürgen Scherkenbeck, Guiscard Seebohm   +12 more
doaj   +1 more source

Allisartan ameliorates vascular remodeling through regulation of voltage-gated potassium channels in hypertensive rats

BMC Pharmacology and Toxicology, 2021
Background The objective of the present study was to determine the effect of allisartan, a new angiotensin II type 1 receptor antagonist on vascular remodeling through voltage gated potassium channels (Kv7) in hypertensive rats.
Xiaoqin Zhang, Ziying Zhao, Chunfang Xu, Fengping Zhao, Zhiqiang Yan   +4 more
doaj   +1 more source

Functional significance of axonal Kv7 channels in hippocampal pyramidal neurons [PDF]

Proceedings of the National Academy of Sciences, 2008
Members of the Kv7 family (Kv7.2–Kv7.5) generate a subthreshold K + current, the M− current. This regulates the excitability of many peripheral and central neurons. Recent evidence shows that Kv7.2 and Kv7.3 subunits are targeted to the axon initial segment of hippocampal neurons by ...
Shah MM, Migliore M, Valencia I, Cooper EC, Brown DA   +4 more
openaire   +4 more sources

Parvalbumin interneurons in Alzheimer's disease: Physiological insights and pathophysiological mechanisms

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
Physiological and Pathological Alterations in PV+ Neurons: Under physiological conditions, PV+ interneurons exhibit fast‐spiking properties and generate gamma oscillations at the cost of high energy consumption. In AD, PV+ neurons display abnormalities in ion channels, dendrites, neurotransmission, energy metabolism, and neural oscillations, ultimately
Mengyan Wu, Xingdong Zeng, Yongle Cai, Haonan Chen, Qianying Li, Hao Yang   +5 more
wiley   +1 more source

The renal vasodilatation from β‐adrenergic activation in vivo in rats is not driven by KV7 and BKCa channels

Experimental Physiology
The mechanisms behind renal vasodilatation elicited by stimulation of β‐adrenergic receptors are not clarified. As several classes of K channels are potentially activated, we tested the hypothesis that KV7 and BKCa channels contribute to the decreased ...
Charlotte Mehlin Sorensen, Max Salomonsson, Anniek Frederike Lubberding, Niels‐Henrik Holstein‐Rathlou   +3 more
doaj   +1 more source

Ganoderic Acid A Ameliorates Pentylenetetrazol‐Induced Epilepsy in Mice via Activating KCNQ2

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
GA‐A binds and activates KCNQ2, thereby reducing epileptic‐like EEG discharges, the loss and apoptosis of hippocampal neurons, and improving anxiety and depression‐like behavioral changes. In addition, GA‐A inhibits neuroinflammation and alleviates oxidative stress independent of activating KCNQ2.
Yang Yao, Zhujun Liu, Xujiao Wang, Cunhao Bian, Rui Wang, Yukun Zhang   +5 more
wiley   +1 more source

KV7 Channels Regulate Firing during Synaptic Integration in GABAergic Striatal Neurons

Neural Plasticity, 2015
Striatal projection neurons (SPNs) process motor and cognitive information. Their activity is affected by Parkinson’s disease, in which dopamine concentration is decreased and acetylcholine concentration is increased.
M. Belén Pérez-Ramírez, Antonio Laville, Dagoberto Tapia, Mariana Duhne, Esther Lara-González, José Bargas, Elvira Galarraga   +6 more
doaj   +1 more source