Results 151 to 160 of about 1,204,901 (187)

The cornea-trigeminal axis: potassium channels as master regulators of ocular surface homeostasis and sensory transduction. [PDF]

Front Cell Dev Biol
Zhang J, Chen X, Ji J, Chen P, Yao J, Liu L, Tang L, Wen X.   +7 more
europepmc   +1 more source

Cannabidiol inhibits both human K_V7.1 and K_V7.1/KCNE1 channels through distinct sites. [PDF]

Acta Pharmacol Sin
Kusay AS, Pökl M, Hiniesto-Iñigo I, Sridhar A, Delemotte L, Liin SI.   +5 more
europepmc   +1 more source

Kv7 channels as pharmacological targets for CNS diseases

Pharmacological Reviews
Francesco Miceli, Maria Virginia Soldovieri, Vincenzo Barrese, Maurizio Taglialatela   +3 more
openaire   +1 more source

G-protein βγ subunits are positive regulators of Kv7.4 and native vascular Kv7 channel activity

Proceedings of the National Academy of Sciences of the United States of America, 2015
Kv7.4 channels are a crucial determinant of arterial diameter both at rest and in response to endogenous vasodilators. However, nothing is known about the factors that ensure effective activity of these channels.
Vincenzo Barrese, Iain Greenwood, Oleksandr Povstyan   +2 more
exaly   +2 more sources

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Inhibition of Kv7/M Channel Currents by Fangchinoline

Pharmacology, 2022
Introduction: Voltage-gated Kv7/M potassium channels play an essential role in the control of membrane potential and neuronal excitability. Fangchinoline, a bisbenzylisoquinoline alkaloid, displays extensive biological activities including antitumor, anti-inflammatory, and antihypertension effects.
Han Li, DanDan Geng, Rong Zheng, Runmeng Wang, Yaning Li, Yidong Liu, Qingzhong Jia, Fan Zhang   +7 more
openaire   +2 more sources

Kv7 Channels as Targets for the Treatment of Pain

Current Pharmaceutical Design, 2009
Kv7.x channels are a family of six transmembrane domain, single pore-loop, voltage-gated K(+) channels. Five members of the family have been identified to date, including the cardiac channel Kv7.1 (formerly known as KvLQT1) and four neuronal Kv7.x channels, Kv7.2-5. Heteromeric channels containing Kv7.3 and either Kv7.2 or Kv7.5 are thought to underlie
A D, Wickenden, G, McNaughton-Smith
openaire   +2 more sources

Kv7 (KCNQ) channel openers induce hypothermia in the mouse

Neuroscience Letters, 2011
Kv7 channels, encoded by corresponding kcnq genes, are expressed both centrally and peripherally where they serve to dampen neuronal activity. While Kv7 channel openers have shown efficacy in neurological and neuropsychiatric disease models, the impact of Kv7 channel activation on physiological endpoint markers have not been addressed in detail.
Henrik H Hansen
exaly   +3 more sources

Decreased expression of Kv7 channels in Hirchsprung's disease

Journal of Pediatric Surgery, 2017
Voltage-dependent K+ channels (Kv channels) participate in electrical rhythmicity and smooth muscle responses and are regulated by excitatory and inhibitory neurotransmitters. Kv channels also participate in the interstitial cell of Cajal (ICC) and smooth muscle cell (SMC) responses to neural inputs.
Anne-Marie, O'Donnell, David, Coyle, Prem, Puri   +2 more
openaire   +2 more sources

Driving With No Brakes: Molecular Pathophysiology of Kv7 Potassium Channels

Physiology, 2011
Kv7 potassium channels regulate excitability in neuronal, sensory, and muscular cells. Here, we describe their molecular architecture, physiological roles, and involvement in genetically determined channelopathies highlighting their relevance as targets for pharmacological treatment of several human disorders.
SOLDOVIERI, Maria Virginia, Miceli F, TAGLIALATELA, Maurizio   +2 more
openaire   +3 more sources