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Discovery of a novel Kv7 channel opener as a treatment for epilepsy
Bioorganic and Medicinal Chemistry Letters, 2015Facilitating activation, or delaying inactivation, of the native Kv7 channel reduces neuronal excitability, which may be beneficial in controlling spontaneous electrical activity during epileptic seizures. In an effort to identify a compound with such properties, the structure-activity relationship (SAR) and in vitro ADME for a series of heterocyclic ...
Allen Duplantier +2 more
exaly +3 more sources
Bladder contractility is modulated by Kv7 channels in pig detrusor
European Journal of Pharmacology, 2013Kv7 channels are involved in smooth muscle relaxation, and accordingly we believe that they constitute potential targets for the treatment of overactive bladder syndrome. We have therefore used myography to examine the function of Kv7 channels in detrusor, i.e.
Svalø, Julie +5 more
openaire +3 more sources
Proceedings of the National Academy of Sciences of the United States of America, 2018
Eider Nunez Viadero +2 more
exaly
Eider Nunez Viadero +2 more
exaly
A Calmodulin C-Lobe Ca2+-Dependent Switch Governs Kv7 Channel Function
Neuron, 2018Daniel Minor +2 more
exaly
The therapeutic potential of neuronal KV7 (KCNQ) channel modulators: an update
Expert Opinion on Therapeutic Targets, 2008Valentin K Gribkoff
exaly