Results 31 to 40 of about 922,464 (301)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Towards a digital model of zebrafish embryogenesis. Integration of Cell Tracking and Gene Expression Quantification [PDF]

, 2010
We elaborate on a general framework composed of a set of computational tools to accurately quantificate cellular position and gene expression levels throughout early zebrafish embryogenesis captured over a time-lapse series of in vivo 3D images.
Bourgine, Paul, Castro González, Carlos, Desnoulez, Sophie, Douloquin, Louise, Ledesma Carbayo, María Jesús, Luengo Oroz, Miguel Ángel, Melani, Camilo, Peyrieras, Nadine, Santos Lleo, Andres de, Savy, Thierry   +9 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

MEDICIONES SISTEMÁTICAS DE RADIACIÓN UVE - OTOÑO 2011

Anales (Asociación Física Argentina), 2013
Durante el año 2010 se realizaron mediciones de prueba con el medidor de Radiación UVE (correspondiente a la radiación Ultra Violeta en la banda UV dosis Eritémica).
M Lavorato, F Moscatelli, M Correa, M Pagura, M Zanin, P Cesarano, R Faselli, P Bahamonde   +7 more
doaj  

Advantages of Femtosecond Laser Microdrilling PDMS Membranes over Conventional Methods for Organ-on-a-Chip

Journal of Manufacturing and Materials Processing
Organ-on-a-chip (OoC) technology aims to replicate the functions of human organs and tissues. This study evaluates femtosecond laser micromachining (FLM) for producing PDMS membranes with controlled porosity as an alternative approach to conventional ...
Chahinez Berrah, Daniel Sanchez-Garcia, Javier Rodriguez Vazquez Aldana, Andres Sanz-Garcia   +3 more
doaj   +1 more source

Avances en la fabricación de células y módulos fotovoltaicos de silicio en capa fina mediante láser [PDF]

, 2008
El láser es un instrumento omnipresente en la fabricación de módulos fotovoltaicos. Los láser estándar para la interconexión monolítica de dispositivos de lámina delgada de a-Si son láser de estado sólido bombeados por diodo (DPSS) emitiendo en ...
Allen-Perkins, F., Fernández Robledo, Susana, García-Ballesteros Ramírez, Juan José, Guadaño Ayuso, Gonzalo, Lauzurica Santiago, Sara, Molpeceres Álvarez, Carlos Luis, Ocaña Moreno, José Luis   +6 more
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

MÉTODOS DE ESTUDIO DE CAPA LÍMITE ATMOSFÉRICA (CLA) MEDIANTE UN LIDAR DE RETRODIFUSIÓN

Anales (Asociación Física Argentina), 2013
Se estudian distintos métodos para la determinación de la CLA (Capa Limite Atmosférica) mediante un Lidar de Retrodifusión y el rango de validez de los datos.
J. Fochesatto, M. Lavorato, P. Cesarano, E. Quel, P. Flamant, J. Pelon   +5 more
doaj  

Excited States of Proton-bound DNA/RNA Base Homo-dimers: Pyrimidines [PDF]

, 2014
We are presenting the electronic photo fragment spectra of the protonated pyrimidine DNA bases homo-dimers. Only the thymine dimer exhibits a well structured vibrational progression, while protonated monomer shows broad vibrational bands. This shows that
Adesokan A. a, Ahlrichs R., Alata I., Alata I., Alata I., Alata I., Andersen L. H., Bakker J. M., Berdakin M., Berdakin M., Bouchoux G., Boyarkin O. V., Brøndsted Nielsen S., Chakraborty S., Christophe Jouvet, Claude Dedonder-Lardeux, Delchev V. B., Dopfer O., Duncan M. A., Fonseca Guerra C., Fridgen T. D., Féraud G., Féraud G., Gehring K., Grégoire G., Gustavo A. Pino, Géraldine Féraud, Góra R. W., Hattig C., Kamrath M. Z., Kamrath M. Z., Kang H., Kang H., Kang H., Kleinermanns K., Le Barbu-Debus K., Lepere V., Lieblein A. L., Marian C., Matias Berdakin, Mercier S. R., Patzer A., Pino G. A., Rajabi K., Saigusa H., Salpin J.-Y., Schermann J.-P., Schirmer J., Scuderi D., Scuderi D., Sobolewski A. L., Solcà N., Wang X. B., Yang B., Yang B., Škríba A.   +55 more
core   +5 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source