Results 51 to 60 of about 940,829 (241)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
EXCITACIÓN DE UN LÁSER DE CO2 MEDIANTE MICROONDAS
Anales (Asociación Física Argentina), 2013 Mediante un magnetrón de uso comercial operado en forma continua se excita una mezcla láser de CO2 confinada en una guía rectangular de 15 mm por 282 mm de sección, acoplada a la guía rectangular principal mediante dos bocinas; la primera del tipo ...
I. J. Ríos +5 more
doaj
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Ultrafast pulse train characterization via a-swing: Single-shot scheme and stability analysis [PDF]
EPJ Web of ConferencesA current hot topic on ultrafast pulse characterization is the diagnosis of ultrafast pulses including train instabilities, due to its significant impact on the laser source performance.
Barbero Cristian +2 more
doaj +1 more source
Ultrafast sub-nanometer matter-wave temporal Talbot effect
New Journal of Physics, 2021 The coherent manipulation of the electron wavefunction at the atomic spatial and temporal scales is the fundamental breakthrough underlying far-reaching ultrafast phenomena as high-order harmonic radiation and attosecond pulse generation.
Ana García-Cabrera +2 more
doaj +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
, 1973 Pequeña nota histórica del proceso seguido en el desarrollo del láser, o más general, de la electrónica cuántica, de la que el láser fue promotor y protagonista. Se analiza igualmente el método de trabajo de un material láser y qué son las propiedades de
Martín Pereda, José Antonio
core
Desarrollo de combustibles sólidos para propulsión láser [PDF]
, 2023 En estos últimos años la propulsión láser ha ganado la atención de los grupos de investigación de propulsión alrededor del mundo. En primer lugar, h an emergido los sistemas láser con media y ultra-alta energía que encontraron su aplicación en la ...
Rinaldi, Carlos +7 more
core
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source