Results 41 to 50 of about 900,349 (201)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

UNA PROPUESTA PARA REGISTRAR EL DESPLAZAMIENTO DOPPLER DE ONDAS DE LUZ Y “OÍR” SUS BATIDOS

Anales (Asociación Física Argentina), 2012
A pesar que el corrimiento Doppler es un tópico bien conocido, el diseño de experimentos para su enseñanza utilizando ondas de luz no es simple. Esta es una de las razones por la que generalmente, en cursos de física básica, la enseñanza de este tema se ...
G G Romero, E. E. Alanís, C. C. Martínez, D. O. Dominguez   +3 more
doaj  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Lipólisis láser y liposucción en ginecomastia: retracción cutánea eficaz y segura

Revista do Colégio Brasileiro de Cirurgiões
OBJETIVO: Valorar la eficacia de la lipólisis-láser para corregir el volumen, flacidez y excedente cutáneo sin escisión. MÉTODOS: Prospectivamente, en 32 pacientes con ginecomastia, bajo anestesia tumescente y sedación se realizó lipólisis con láser de ...
Mario Trelles, Enrique Bonanad, Javier Moreno-Moraga, Justo Alcolea, Serge Mordon, Franck Marie Leclère   +5 more
doaj   +1 more source

Generating clean few-cycle pulses in an all-bulk multipass cell scheme [PDF]

EPJ Web of Conferences
We theoretically demonstrate the generation of clean few-cycle pulses in a three-stage all-bulk multipass cell scheme. By meticulously selecting the number of round trips and the width of the material used in each cell, we are able to keep the three ...
Segundo Staels Víctor Wilfried, Conejero Jarque Enrique, San Roman Julio   +2 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Topological high-harmonic spectroscopy

Communications Physics
Linearly polarized vector beams are structured lasers whose topology is characterized by a well-defined Poincaré index, which is a topological invariant during high-order harmonic generation.
Ana García-Cabrera, Roberto Boyero-García, Óscar Zurrón-Cifuentes, Javier Serrano, Julio San Román, Luis Plaja, Carlos Hernández-García   +6 more
doaj   +1 more source

Self-calibrating d-scan: measuring ultrashort laser pulses on-target using an arbitrary pulse compressor

Scientific Reports, 2018
In most applications of ultrashort pulse lasers, temporal compressors are used to achieve a desired pulse duration in a target or sample, and precise temporal characterization is important.
Benjamín Alonso, Íñigo J. Sola, Helder Crespo   +2 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source