Results 121 to 130 of about 14,286,973 (221)
Journal of FisheriesThe rapid expansion of recirculating aquaculture system (RAS) aquaculture demands precise dietary strategies. Determining optimal tryptophan levels and understanding their combined effects on growth, blood responses, and stress regulation in Asian ...
Manikandan Kalidoss +2 more
doaj +1 more source
Advanced Science, EarlyView.This study reveals that during skeletal aging, bone marrow adipocyte‐derived sDPP4 primes STING signaling in macrophages. In combination with mitochondrial DNA, this signaling activates CD38 and depletes local NAD+/NMN, thereby impairing osteogenesis.
Zhichao Li +12 more
wiley +1 more source
Structural consequences of two methyl additions in the E. coli trp repressor L-tryptophan binding pocket [PDF]
, 1995 The flexibility and specificity of the L-tryptophan corepressor binding pocket of E coli trp repressor are being investigated by high-resolution crystallographic examination of aporepressor/corepressor analog complexes.
Lawson, C.L.
core
Highly sensitive and selective detection of L-tryptophan by ECL using boron-doped diamond electrode
, 2023 International audienceWe report here on the detection of L-Tryptophan, an essential amino-acid involved in neurological functions, using co-reactant-less electrochemiluminescence on boron doped diamond (BDD) electrode.
Hamel, Matthieu +2 more
core
Advanced Science, EarlyView.Using a novel, aptamer‐based biosensor, here we have performed 20‐s‐resolved, in situ measurements of plasma‐free tryptophan in the jugular veins of live rats (blue). This unprecedented time‐resolution provides insights into the regulation of tryptophan metabolism in live, intact animals.
Yuyang Wu +7 more
wiley +1 more source
The serum L-kynurenine/L-tryptophan ratio and tissue gene expression of IDO and TDO.
, 2016 A, The serum L-kynurenine/L-tryptophan ratio (Kyn/Trp) was determined at 32 weeks by measuring the concentrations of L-kynurenine and L-tryptophan using HPLC. (B, C) Liver tissues were separated into hepatic tumors and non-tumorous tissues. Total RNA was
Mitsuru Seishima (455723) +12 more
core +1 more source
Advanced Science, EarlyView.Chronic stress reshapes the gut microbiota and enriches Lactobacillus reuteri, promoting microbiota‐associated kynurenine accumulation through altered tryptophan metabolism. Kynurenine drives immunosuppressive remodeling of tumor‐associated macrophages through TNFR2–C/EBPβ signaling, thereby enhancing gastric cancer dissemination.
Sicheng Zhao +9 more
wiley +1 more source
Self‐Assembling Peptide‐Adjuvant Conjugate (SaPAC) Platform for Precision Cancer Immunotherapy
Advanced Science, EarlyView.A self‐assembling peptide–adjuvant conjugate links neoantigens to TLR7 agonism, forming cationic nanoparticles that enhance lymph‐node retention, dendritic‐cell activation, and antitumor T‐cell immunity. This chemically defined platform shows how synchronized antigen and innate stimulation can be adapted across melanoma, bladder cancer, and triple ...
Yang‐Fan Wu +15 more
wiley +1 more source
Spectroscopic characterization of Cu(II) complex of l-phenylalanine and d,l-tryptophan
, 2010 In this work, the reactions involving L-phenylalanine and D,L-tryptophan in the presence of Cu(II) ion were studied. Optimum conditions for the reactions were established as pH 7 and lambda=641 nm.
Bilcen, Selin +3 more
core +1 more source
Advanced Science, EarlyView.Diabetes‐associated dysbiosis is accompanied by reduced Clostridium abundance, impaired microbial tryptophan metabolism, and lower circulating indole‐3‐propionic acid (IPA). Exogenous IPA improves trabecular microarchitecture and bone formation and restores Nrf2‐associated antioxidant signaling in bone marrow mesenchymal stem cells, limiting iron ...
Jinwu Bai +12 more
wiley +1 more source