Results 71 to 80 of about 14,286,973 (221)

The effect of metergoline on endocrine responses to L-tryptophan.

, 2016
The effects of the 5-HT receptor antagonist, metergoline, on the prolactin and growth hormone responses to intravenous L-tryptophan were assessed in seven normal subjects.

core   +1 more source

L-tryptophan-D5

, 2017
Inelastic Neutron Scattering spectrum of L-tryptophan-D5, C₁₁H₇D₅N₂O₂, measured on the TOSCA instrument.
J. Tomkinson, ISIS
core   +2 more sources

An Anti‐Amyloidogenic Approach to Specifically Block Memory Consolidation in Mice for Therapeutic Intervention

Advanced Science, EarlyView.
Functional amyloid conversion of the translation regulator CPEB3 is essential for long‐term memory persistence. This study demonstrates that targeting this molecular switch with the anti‐amyloidogenic peptide QBP1 selectively blocks CPEB3 fibrillation without disrupting phase separation.
Paula López‐García, Kerry R. McGreevy, Maria Eugenia Vaquero, Juan M. Suarez‐Rivero, Antonio Moreno‐Rodríguez, Antonio J. Pérez‐Pulido, Daniel Ramírez de Mingo, Anna Pallé, Helena Akiko Popiel, Andrea Santi, Mario D. Cordero, José Luis Trejo, Yoshitaka Nagai, Mariano Carrión‐Vázquez   +13 more
wiley   +1 more source

Effect of 3-phenylamino-l-alanine on tryptophan binding to rat hepatic nuclear envelopes

, 1994
We have determined that the addition of 3-phenylamino-l-alanine (PAA), a recently reported contaminant in l-tryptophan implicated in the eosinophilia-myalgia syndrome, affects tryptophan binding by utilizing an in vitro measurement of 3H-tryptophan ...
Verney, Ethel, Sidransky, Herschel, Latham, Patricia S., Cosgrove, James W.   +3 more
core   +1 more source

Metabolic engineering of Streptomyces albulus for de novo serotonin production

Microbial Cell Factories
Background Serotonin (5-hydroxytryptamine, 5-HT) is a pivotal neurotransmitter with broad clinical relevance. However, its industrial-scale microbial production remains a significant challenge. In this study, we engineered Streptomyces albulus to develop
Yuan Zhang, Aoxiang Liu, Min Zhang, Jiabei Song, Qian Wang, Yongxuan Liu, Qingshou Yao, Linghui Kong, Xiuwen Wang, Jiayang Qin   +9 more
doaj   +1 more source

Rapid Evaluation and Optimization of Medium Components Governing Tryptophan Production by Pediococcus acidilactici TP-6 Isolated from Malaysian Food via Statistical Approaches

Molecules, 2020
Tryptophan is one of the most extensively used amino acids in livestock industry owing to its effectiveness in enhancing the growth performance of animals.
Ye Heng Lim, Hooi Ling Foo, Teck Chwen Loh, Rosfarizan Mohamad, Raha Abdul Rahim   +4 more
doaj   +1 more source

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source

Gonadotropin‐Inhibitory Hormone (GnIH) and Its Receptor GPR147 Mediates Acute Stress‐Induced Activation of the Locus Coeruleus‐SAM Axis

Advanced Science, EarlyView.
ABSTRACT Gonadotropin‐inhibitory hormone (GnIH, also known as RFamide‐related peptide‐3, RFRP‐3) is a hypothalamic neuropeptide that regulates vertebrate reproduction via its receptor GPR147. Although GnIH is known to mediate stress‐induced reproductive suppression, its role in broader stress responses remains unclear.
Jiani Zhang, Hongyu Zhu, Wenqi Wang, Bingqian Shen, Yuanyuan Xin, Xingxing Song, Xuanyi Lu, Lixuan Li, Siting Chen, Xiaochen Zhang, Jialing Zeng, Haodong Zheng, Jianlong Lao, Ke Peng, Yixian Wei, Jiaming Zheng, Chuanhuo Hu, Xiaoye Wang, Xun Li   +18 more
wiley   +1 more source

Altered Tryptophan Catabolism in Placentas From Women With Pre-eclampsia

, 2019
Background: The kynurenine pathway enzymes, breaking down tryptophan, are abundant in placental tissue. These metabolites are involved in immunoregulatory mechanisms, although the role of this pathway in pre-eclampsia (PE) has only begun to be ...
Sarah A Keaton, Patrick Heilman, Grit, Jamie, Karen Racicot, Maya Jälmby, Zachary Madaj, Jälmby, Maya, Asgerally Fazleabas, Miller, Emily S., Brundin, Lena, Keaton, Sarah A., Racicot, Karen, Madaj, Zachary, Emily S Miller, Stefan R Hansson, Grigoros Kalapotharakos, Fazleabas, Asgerally, Kalapotharakos, Grigoros, Lena Brundin, Hansson, Stefan R., Stanislaw Krzyzanowski, Bryleva, Elena Y., Jamie Grit, Elena Y Bryleva, Heilman, Patrick, Krzyzanowski, Stanislaw, Hansson, Stefan R.,, Brundin, Lena,, Grit, Jamie,, Jälmby, Maya,, Madaj, Zachary,, Fazleabas, Asgerally,, Keaton, Sarah A.,, Racicot, Karen,, Heilman, Patrick,, Krzyzanowski, Stanislaw,, Lund University., Miller, Emily S.,, Bryleva, Elena Y.,   +38 more
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Underground Signals: The Ecological Power of Root Volatiles

Advanced Science, EarlyView.
Root volatiles mediate rhizosphere chemical communication, shaping interactions among plants, microbes, herbivores, and natural enemies. Their production, transport, and perception underpin ecological adaptation, multitrophic interactions, and plant resilience, offering opportunities for sustainable crop protection, resilient agroecosystems, and ...
Xueyao Cao, Nanli Song, François Verheggen, Meritxell Pérez‐Hedo, Andrea Clavijo McCormick, Antonino Cusumano, Arthur de Fouchier, Bing Wang, Chen‐Zhu Wang, Emmanuelle Jacquin‐Joly, Gary W. Felton, Geoff M. Gurr, Hao Guo, Jiancai Li, Jin Zhang, Li Chen, Manqun Wang, Michele Ricupero, Peng Han, Peng He, Qi Yan, Qingbo Tang, Qingsong Liu, Shiheng An, Xiangbo Kong, Xiaoling Sun, Xueming Ren, Yuanyuan Song, Yang Liu, Yanhui Guo, Yunhe Li, Xiao Sun   +31 more
wiley   +1 more source