Results 1 to 10 of about 31,314 (176)

A Career's Work, the l-Arabinose Operon: How It Functions and How We Learned It. [PDF]

open access: greenEcoSal Plus, 2022
Very few labs have had the good fortune to have been able to focus for more than 50 years on a relatively narrow research topic and to be in a field in which both basic knowledge and the research technology and methods have progressed as rapidly as they ...
Schleif R.
europepmc   +7 more sources

The Escherichia coli L-arabinose operon: binding sites of the regulatory proteins and a mechanism of positive and negative regulation. [PDF]

open access: greenProceedings of the National Academy of Sciences, 1980
The locations of DNA binding by the proteins involved with positive and negative regulation of transcription initiation of the L-arabinose operon in Escherichia coli have been determined by the DNase I protection method.
S Ogden   +4 more
semanticscholar   +6 more sources

Fine-Structure Deletion Map of the Escherichia coli L-Arabinose Operon [PDF]

open access: greenProceedings of the National Academy of Sciences, 1972
A fine-structure deletion map of the L-arabinose operon of E. coli was constructed by mapping deletion endpoints against point mutations. Of 350 independent deletions with average endpoint separation of ten nucleotides, 51 ended in the control region ...
Robert Schleif
semanticscholar   +5 more sources

AraC protein, regulation of the l-arabinose operon inEscherichia coli, and the light switch mechanism of AraC action [PDF]

open access: bronzeFEMS Microbiology Reviews, 2010
This review covers the physiological aspects of regulation of the arabinose operon in Escherichia coli and the physical and regulatory properties of the operon's controlling gene, araC.
Robert Schleif
semanticscholar   +4 more sources

Electron microscopy of gene regulation: The L -arabinose operon [PDF]

open access: greenProceedings of the National Academy of Sciences, 1976
Unlike normal cells, malignant rat and two simian virus 40-transformed human cell lines can neither grow nor survive in B12- and folate-supplemented media in which methionine is replaced by homocysteine.
Jay Hirsh, Robert Schleif
semanticscholar   +6 more sources

THE L-ARABINOSE OPERON IN Escherichia coli B/r: A GENETIC DEMONSTRATION OF TWO FUNCTIONAL STATES OF THE PRODUCT OF A REGULATOR GENE [PDF]

open access: greenProceedings of the National Academy of Sciences, 1969
The product of the regulator gene araC in the L-arabinose gene complex exists in two functional states: P1, the repressor, and P2, the activator, presumably in equilibrium with each other, and with P1 and P2 attached to their respective controlling sites,
Ellis Englesberg   +2 more
semanticscholar   +5 more sources

Metabolite gene regulation of the L-arabinose operon in Escherichia coli with indoleacetic acid and other indole derivatives. [PDF]

open access: greenProceedings of the National Academy of Sciences, 1980
The ability of indole derivatives to facilitate RNA polymerase transcription of the L-arabinose operon in Escherichia coli was shown to require the catabolite activator protein (CAP) as well as the araC gene product.
Ellis L. Kline   +4 more
semanticscholar   +5 more sources

Regulation of the l-arabinose operon of Escherichia coli [PDF]

open access: hybridTrends in Genetics, 2000
Over forty years of research on the L-arabinose operon of Escherichia coli have provided insights into the mechanism of positive regulation of gene activity. This research also discovered DNA looping and the mechanism by which the regulatory protein changes its DNA-binding properties in response to the presence of arabinose.
Robert Schleif
semanticscholar   +5 more sources

Polarity in Gene araB of the l -Arabinose Operon in Escherichia coli B/r [PDF]

open access: bronzeJournal of Bacteriology, 1969
A series of mutations are described which map in the araB gene of the l -arabinose operon and exert a polar effect on gene araA , the structural gene for the l -arabinose isomerase.
David E. Sheppard, Derinda A. Walker
semanticscholar   +5 more sources

Transcriptional Control in the l -Arabinose Operon of Escherichia coli B/r [PDF]

open access: bronzeJournal of Bacteriology, 1974
The structural genes involved in l -arabinose metabolism are regulated by the protein product of the araC gene. This protein functions as both an activator and repressor of enzyme synthesis in this gene complex.
P. Patrick Cleary, Ellis Englesberg
semanticscholar   +5 more sources

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