Results 41 to 50 of about 18,029 (193)

Potent CRISPR-Cas9 inhibitors from Staphylococcus genomes. [PDF]

, 2020
Anti-CRISPRs (Acrs) are small proteins that inhibit the RNA-guided DNA targeting activity of CRISPR-Cas enzymes. Encoded by bacteriophage and phage-derived bacterial genes, Acrs prevent CRISPR-mediated inhibition of phage infection and can also block ...
Doudna, Jennifer A, Fellmann, Christof, Lew, Rachel J, McMahon, Blake, Shivram, Haridha, Watters, Kyle E   +5 more
core   +3 more sources

Autoregulation of the Escherichia coli melR promoter: repression involves four molecules of MelR [PDF]

, 2008
The Escherichia coli MelR protein is a transcription activator that autoregulates its own promoter by repressing transcription initiation. Optimal repression requires MelR binding to a site that overlaps the melR transcription start point and to upstream
Belyaeva, Bourgerie, Caswell, Choy, David C. Grainger, Gallegos, Grainger, Grainger, Gralla, Hansma, Ishihama, Kachroo, Kahramanoglou, Kolb, Lee, Lodge, Martin, Meares, Michán, Miller, Mohamed Samir El-Robh, Panos Soultanas, Perrin, Plumbridge, Rojo, Roy, Schleif, Schleif, Semsey, Shivanthi Samarasinghe, Stephen J. W. Busby, Tobes, Virnik, Wade, Wade, Wang, Webster, Webster, Webster, Wenke Zhang, Williams, Zhang   +41 more
core   +4 more sources

Carboxydotrophic Acetogenesis in Alkaline Conditions Results in Transient Formate Production by the Halo‐Alkaliphilic Acetogen Haloacetibacter carboxydivorans Gen. Nov. sp. Nov

Environmental Microbiology Reports, Volume 18, Issue 1, February 2026.
This work presents the physiological exploration of the halo‐alkaliphilic, carboxydotrophic acetogen bacterium MD4. In contrast to well‐characterised neutrophilic and slightly acidophilic acetogenic carboxydotrophs, this work shows an important role for formate production, instead of ethanol, as a redox exhaust mechanism in alkaline conditions ...
Martijn Diender, Isabelle M. Keijsers, Anastasia Galani, Timo van Roosmalen, Alfons J. M. Stams, Diana Z. Sousa   +5 more
wiley   +1 more source

The pmrCAB Operon Mediates Polymyxin Resistance In Acinetobacter Baumannii ATCC 17978 And Clinical Isolates Through Phosphoethanolamine Modification Of Lipid A [PDF]

, 2011
The emergence of multidrug resistance among Acinetobacter baumannii is leading to an increasing dependence on the use of polymyxins as last-hope antibiotics. Here, we utilized genetic and biochemical methods to define the involvement of the pmrCAB operon
Arroyo, Luis A., Fernandez, Lucia, Hancock, Robert E. W., Hankins, Jessica V., Herrera, Carmen M., Trent, M. Stephen   +5 more
core   +2 more sources

Laccases from lactic acid bacteria show cuprous oxidase activity and capture Cu(II) and Ag(I) ions

Protein Science, Volume 35, Issue 1, January 2026.
Abstract Several laccases derived from lactic acid bacteria (LAB) display specific structural features, such as two methionine residues at the entrance of the T1Cu center, and an extended C‐terminal end enriched in methionine and histidine. To investigate their functional roles, we engineered mutant variants of the laccase Pp4816 from Pediococcus ...
Raquel Gascó, Ramon Sendra, Isidoro Olmeda, Francisco Paredes‐Martínez, Sergi Ferrer, Isabel Pardo, Patricia Casino   +6 more
wiley   +1 more source

L-Arabinose Isomerase Formation in a Conditional Mutant of Gene \u3cem\u3earaA\u3c/em\u3e of \u3cem\u3eEscherichia coli\u3c/em\u3e B/r [PDF]

, 1972
A temperature-sensitive mutant of Escherichia coli in which the synthesis of l-arabinose isomerase is blocked during growth at 42 C was found to possess the following properties.
Irr, Joseph, Pauley, Judith, Power, Joseph   +2 more
core   +1 more source

Interaction of Staphylococcus aureus di‐iron Repair of Iron Centers protein with the iron–sulfur cluster assembly SUF system

Protein Science, Volume 35, Issue 1, January 2026.
Abstract Repair of Iron Centers (RIC) proteins are present in several pathogens, including Staphylococcus aureus, contributing to resistance to nitroxidative stress and virulence. In this work, we investigated the molecular mechanisms by which S. aureus RIC facilitates iron mobilization, through structural analyses and functional studies.
Frederico M. Lourenço, Liliana S. O. Silva, Mafalda R. Almeida, Filipe Folgosa, Pedro M. Matias, Sandra M. Carvalho, João C. Lima, Célia V. Romão, Lígia M. Saraiva   +8 more
wiley   +1 more source

Understanding and elimination of carbon catabolite repression in Escherichia coli [PDF]

, 2012
BioengineeringMicroorganisms often encounter a mixture of different carbon sources and therefore have control systems to selectively take up and metabolize those substrates that promise the best success in competition with other species through rapid ...
Park, Jung Min
core  

A unified design space of synthetic stripe-forming networks [PDF]

, 2014
Synthetic biology is a promising tool to study the function and properties of gene regulatory networks. Gene circuits with predefined behaviours have been successfully built and modelled, but largely on a case-by-case basis.
Cotterell, J, Gili, M, Isalan, M, Munteanu, A, Schaerli, Y, Sharpe, J   +5 more
core   +3 more sources

Genetic Diversity of Polymyxin Resistance Genes in Klebsiella pneumoniae Clinical Isolates

Molecular Ecology, Volume 35, Issue 2, January 2026.
ABSTRACT This study investigates the genetic diversity and evolutionary mechanisms driving polymyxin resistance in Klebsiella pneumoniae, a critical priority pathogen. By analysing mgrB, phoPQ and pmrAB genes in susceptible (PM‐S) and resistant (PM‐R) populations through neutrality tests (Tajima D, Fu & Li's D) we uncovered polygenic adaptation and ...
Daniel Miceli Serwy, Maria Eduarda Rocha Conde, Ana Luiza Carneiro Alencar, Roberto Leonan Morim Novaes, Josué da Costa Lima‐Junior, Fabio Faria da Mota, Ana Paula Carvalho‐Assef, Teca Calcagno Galvao, Viviane Zahner   +8 more
wiley   +1 more source