The Effect of Stochasticity on the Lac Operon: An Evolutionary Perspective [PDF]
PLoS Computational Biology, 2007 The role of stochasticity on gene expression is widely discussed. Both potential advantages and disadvantages have been revealed. In some systems, noise in gene expression has been quantified, in among others the lac operon of Escherichia coli.
Milan Van Hoek, Paulien Hogeweg
exaly +8 more sources
The Selective Advantage of the lac Operon for Escherichia coli Is Conditional on Diet and Microbiota Composition [PDF]
Frontiers in Microbiology, 2021 The lac operon is one of the best known gene regulatory circuits and constitutes a landmark example of how bacteria tune their metabolism to nutritional conditions.
Catarina Pinto +3 more
doaj +4 more sources
Origin of bistability in the lac Operon. [PDF]
Biophys J, 2007 Multistability is an emergent dynamic property that has been invoked to explain multiple coexisting biological states. In this work, we investigate the origin of bistability in the lac operon. To do this, we develop a mathematical model for the regulatory pathway in this system and compare the model predictions with other experimental results in which ...
Santillán M, Mackey MC, Zeron ES.
europepmc +5 more sources
Wrapped-around models for the lac operon complex. [PDF]
Biophys J, 2010 The protein-DNA complex, involved in the lac operon of enteric bacteria, is paradigmatic in understanding the extent of DNA bending and plasticity due to interactions with protein assemblies acting as DNA regulators. For the lac operon, two classes of structures have been proposed: 1), with the protein tetramer lying away from the DNA loop (wrapped ...
La Penna G, Perico A.
europepmc +7 more sources
Lac Operon Boolean Models: Dynamical Robustness and Alternative Improvements
Mathematics, 2021 In Veliz-Cuba and Stigler 2011, Boolean models were proposed for the lac operon in Escherichia coli capable of reproducing the operon being OFF, ON and bistable for three (low, medium and high) and two (low and high) parameters, representing the ...
Marco Montalva-Medel +2 more
exaly +4 more sources
Diversity in
mBio, 2019 Transcription of bacterial genes is controlled by the coordinated action of cis- and trans-acting regulators. The activity and mode of action of these regulators can reflect different requirements for gene products in different environments.
Kelly N. Phillips +6 more
doaj +2 more sources
Building the lac Operon: A Guided-Inquiry Activity Using 3D-Printed Models [PDF]
Journal of Microbiology & Biology Education, 2020 Undergraduate biology courses rely heavily on visual representation of information. Students view images of plants, animals, and microbes, interpret data presented in graphs, and use drawings to understand how cells and molecules interact in three ...
Claire L. Gordy +4 more
doaj +2 more sources
Acquisition of the lac operon by Salmonella enterica. [PDF]
BMC Microbiol, 2015 Classical bacteriological characteristics of Salmonella enterica indicate that the members of this species are unable to utilize lactose as a carbon source. However, lactose-fermenting (Lac+) strains of several Salmonella serovars have been isolated from different foodborne outbreaks as well as different geographical regions worldwide.
Leonard SR, Lacher DW, Lampel KA.
europepmc +4 more sources
Hybrid de novo Genome Assembly of Erwinia sp. E602 and Bioinformatic Analysis Characterized a New Plasmid-Borne lac Operon Under Positive Selection [PDF]
Frontiers in Microbiology, 2021 Our previous study identified a new β-galactosidase in Erwinia sp. E602. To further understand the lactose metabolism in this strain, de novo genome assembly was conducted by using a strategy combining Illumina and PacBio sequencing technology. The whole
Yu Xia +10 more
doaj +2 more sources
Development of a Lac Operon Concept Inventory (LOCI). [PDF]
CBE Life Sci Educ, 2016 Concept inventories (CIs) are valuable tools for educators that assess student achievement and identify misconceptions held by students. Results of student responses can be used to adjust or develop new instructional methods for a given topic. The regulation of gene expression in both prokaryotes and eukaryotes is an important concept in genetics and ...
Stefanski KM +2 more
europepmc +4 more sources