Results 11 to 20 of about 21,116 (197)
Deterministic and stochastic population-level simulations of an artificial
BMC Bioinformatics, 2011 Background The lac operon genetic switch is considered as a paradigm of genetic regulation. This system has a positive feedback loop due to the LacY permease boosting its own production by the facilitated transport of inducer into the cell and the ...
Zygourakis Kyriacos, Stamatakis Michail
doaj +4 more sources
Structure of the lac Operon Galactoside Acetyltransferase [PDF]
Structure, 2002 The galactoside acetyltransferase (thiogalactoside transacetylase) of Escherichia coli (GAT, LacA, EC 2.3.1.18) is a gene product of the classical lac operon. GAT may assist cellular detoxification by acetylating nonmetabolizable pyranosides, thereby preventing their reentry into the cell.
Wang, Xing-Guo +2 more
openaire +3 more sources
Interplay of protein and DNA structure revealed in simulations of the lac operon. [PDF]
PLoS ONE, 2013 The E. coli Lac repressor is the classic textbook example of a protein that attaches to widely spaced sites along a genome and forces the intervening DNA into a loop.
Luke Czapla +3 more
doaj +2 more sources
Dynamic model of gene regulation for the lac operon
Journal of Physics: Conference Series, 2011 Gene regulatory network is a collection of DNA which interact with each other and with other matter in the cell. The lac operon is an example of a relatively simple genetic network and is one of the best-studied structures in the Escherichia coli bacteria.
Angelova, Maia
core +3 more sources
Genomic characterization of Klebsiella spp. from bovine mastitis: dissemination of a conserved, highly transmissible lacacq+ fec+ plasmid drives burden of disease [PDF]
Applied and Environmental MicrobiologyBovine mastitis poses a significant health concern for dairy cattle and a major economic burden on the dairy industry. Klebsiella spp. are important mastitis pathogens, with previous studies identifying lactose-utilization (lacacq) and iron-acquisition ...
Michael Biggel +5 more
doaj +2 more sources
Pensar con y a partir del operón
Revista Colombiana de Filosofía de la CienciaEste artículo sostiene que el operón lac propuesto por François Jacob y Jacques Monod en 1961 superó los campos de la cinética enzimática y la genética bacteriana en los que se estableció originalmente porque impulsó una metodología de análisis, el ...
Vivette García Deister +1 more
doaj +3 more sources
Bistable behavior of the lac operon in E. coli when induced with a mixture of lactose and TMG
Frontiers in Physiology, 2010 In this work we investigate multistability in the lac operon of Escherichia coli when it is induced by a mixture of lactose and the non-metabolizable thiomethyl galactoside (TMG).
Orlando Díaz-Hernández +3 more
doaj +2 more sources
DNA supercoiling, a critical signal regulating the basal expression of the lac operon in Escherichia coli. [PDF]
Sci Rep, 2016 Escherichia coli lac repressor (LacI) is a paradigmatic transcriptional factor that controls the expression of lacZYA in the lac operon. This tetrameric protein specifically binds to the O1, O2 and O3 operators of the lac operon and forms a DNA loop to ...
Fulcrand G +6 more
europepmc +2 more sources
PLoS ONE, 2021 The cAMP-CRP regulon coordinates transcription regulation of several energy-related genes, the lac operon among them. Lactose, or IPTG, induces the lac operon expression by binding to the LacI repressor, and releasing it from the promoter sequence.
Chunghwan Ro +2 more
doaj +2 more sources
Frontiers in Microbiology, 2022 Lacticaseibacillus casei is used extensively in the fermented milk-beverage industry as a starter culture. Acid production capacity during fermentation is the main criterion for evaluating starters although it is strain-dependent. In this study, the acid
Xiaoxia Li +11 more
doaj +1 more source