Results 41 to 50 of about 36,597 (195)

Molecular Distributions in Gene Regulatory Dynamics [PDF]

, 2010
We show how one may analytically compute the stationary density of the distribution of molecular constituents in populations of cells in the presence of noise arising from either bursting transcription or translation, or noise in degradation rates ...
Acar, Arnold, Berg, Blake, Blake, Bobrowski, Cai, Chubb, Elowitz, Feistel, Fraser, Friedman, Gardiner, Gardner, Gillespie, Golding, Goodwin, Griffith, Griffith, Hawkins, Hierro, Horsthemke, Jacob, Kaern, Kepler, Lasota, Lipniacki, Lipshtat, Mackey, Mariani, Marta Tyran-Kamińska, Michael C. Mackey, Ochab-Marcinek, Ochab-Marcinek, Oppenheim, Othmer, Pichór, Polynikis, Raj, Raj, Raser, Romain Yvinec, Scott, Selgrade, Shahrezaei, Shahrezaei, Shahrezaei, Sigal, Smith, Song, Swain, Titular, Wilemski, Yildirim, Yu, Zacharioudakis   +55 more
core   +5 more sources

Autoregulation of the Escherichia coli melR promoter: repression involves four molecules of MelR [PDF]

, 2008
The Escherichia coli MelR protein is a transcription activator that autoregulates its own promoter by repressing transcription initiation. Optimal repression requires MelR binding to a site that overlaps the melR transcription start point and to upstream
Shivanthi Samarasinghe, Mohamed Samir El-Robh, David C. Grainger, Wenke Zhang, Panos Soultanas, Stephen J. W. Busby, Gralla, Choy, Rojo, Schleif, Schleif, Gallegos, Webster, Belyaeva, Wade, Webster, Webster, Michán, Kahramanoglou, Tobes, Martin, Grainger, Wade, Lodge, Williams, Grainger, Kolb, Perrin, Miller, Caswell, Hansma, Ishihama, Lee, Meares, Virnik, Wang, Zhang, Bourgerie, Semsey, Roy, Plumbridge, Kachroo   +41 more
core   +4 more sources

Use of a Role-Playing Activity To Increase Student Understanding of Bacterial Gene Regulation

Journal of Microbiology & Biology Education, 2023
Undergraduate students often struggle to understand the basics of bacterial gene regulation, a key concept in microbiology. They find it hard to visualize the architecture of a bacterial operon or how the gene, RNA, and protein components interact with ...
Vinaya Sampath
doaj   +1 more source

Population gene introgression and high genome plasticity for the zoonotic pathogen Streptococcus agalactiae [PDF]

, 2019
The influence that bacterial adaptation (or niche partitioning) within species has on gene spillover and transmission among bacteria populations occupying different niches is not well understood.
Abbott, Abby, Almeida, Baily, Bankevich, Beerli, Beerli, Benjamini, Bertels, Bikard, Bisharat, Bishop, Bohnsack, Borchardt, Brett M Probert, Brochet, Bruen, Brynildsrud, Capella-Gutierrez, Chen, Chen, Cheng, Chiara Crestani, Chopra, Christopher D Town, Conrad, Croucher, Da Cunha, Delannoy, Delannoy, Dogan, Edgar, Enright, Erwin, Fernandez, Ferreira, Flores, Fluegge, Garrett H Springer, Gauthier, Glazko, Glazko, Greig, Guglielmini, Gupta, Hayley B Hassler, Heaps, Holt, Imperi, Inouye, Irina M Velsko, Jafar, Jaskowiak, Jeukens, Johri, Jones, Jones, Jorgensen, Joubrel, Kalimuddin, Kim, Konig, Langdon, Librado, Lin, Lindahl, Liu, Liu, Lopez-Sanchez, Loytynoja, Lyhs, Manning, Manning, Martins, Marttinen, Mather, McArthur, Md Tauqeer Alam, Michael J Stanhope, Morse, Murrell, Page, Pal, Paulina D Pavinski Bitar, Pedersen, Petrovska, Pond, Poyart, Price, Qin, Richards, Richards, Richards, Rosinski-Chupin, Ruth N Zadoks, Sahl, Sahl, Sahl, Scheffer, Schrieber, Seemann, Shannon D Manning, Shapiro, Shepheard, Sheppard, Spoor, Springman, Srivastava, Stamatakis, Stoddard, Sukhnanand, Supek, Tettelin, Tettelin, Tian, van der Mee-Marquet, Verani, Viana, Vincent P Richards, Yu, Zadoks, Zankari, Zerbino, Zhang, Zhu   +124 more
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From Binary to Multivalued to Continuous Models: The lac Operon as a Case Study

Journal of Integrative Bioinformatics, 2010
Using the lac operon as a paradigmatic example for a gene regulatory system in prokaryotes, we demonstrate how qualitative knowledge can be initially captured using simple discrete (Boolean) models and then stepwise refined to multivalued logical models ...
Franke Raimo, Theis Fabian J., Klamt Steffen   +2 more
doaj   +2 more sources

The Role of Integration Host Factor in Escherichia coli Persister Formation

mBio, 2022
Persisters represent a small subpopulation of cells that are tolerant of killing by antibiotics and are implicated in the recalcitrance of chronic infections to antibiotic therapy.
Samantha E. Nicolau, Kim Lewis
doaj   +1 more source

Biological Consequences of Tightly Bent DNA: The Other Life of a Macromolecular Celebrity [PDF]

, 2006
The mechanical properties of DNA play a critical role in many biological functions. For example, DNA packing in viruses involves confining the viral genome in a volume (the viral capsid) with dimensions that are comparable to the DNA persistence length ...
Garcia, Hernan G., Grayson, Paul, Han, Lin, Inamdar, Mandar, Kondev, Jane, Nelson, Philip C., Phillips, Rob, Widom, Jonathan, Wiggins, Paul A.   +8 more
core   +3 more sources

Understanding operon architecture using LEGO bricks

Journal of Microbiology & Biology Education
Many undergraduates struggle to interpret abstract concepts in molecular biology. Modeling can facilitate learning by making these abstract concepts tangible.
Dena R. Hammond-Weinberger, Christopher W. Lennon   +1 more
doaj   +1 more source

Network Topology as a Driver of Bistability in the lac Operon

, 2008
The lac operon in Escherichia coli has been studied extensively and is one of the earliest gene systems found to undergo both positive and negative control. The lac operon is known to exhibit bistability, in the sense that the operon is either induced or
Alan Veliz-Cuba, Brandilyn Stigler, Goodwin B., Griffiths A.   +3 more
core   +1 more source

Boolean Models of Bistable Biological Systems

, 2009
This paper presents an algorithm for approximating certain types of dynamical systems given by a system of ordinary delay differential equations by a Boolean network model.
A. Novick, C. Conradi, E. Aurell, F. Jacob, L. Mendoza, M. Cohn, M. Ptashne, M. Santillán, N. Friedman, N. Yildirim, P. Wong, R. Albert, R. de Boer, R. Edwards, R. Laubenbacher, S. A. Kauffman, T. Tian   +16 more
core   +1 more source