Results 51 to 60 of about 18,029 (193)

An Engineered Probiotic Consortium Based on Quorum‐Sensing for Colorectal Cancer Immunotherapy

Advanced Science, Volume 12, Issue 46, December 11, 2025.
This work develops an engineered probiotic consortium sensing pH, hypoxia, and lactate in the tumor microenvironment. It releases a lactate‐depleting enzyme (LdhA) and a PD‐L1 nanobody. In humanized mouse models (MC38 and HT‐29 tumors), it achieves durable oscillations, suppresses tumors, activates CD8+, CD4+, IFN‐γ+ T cells, and reduces Foxp3 ...
Yufei Guo, Mengxue Gao, Lina Wang, Haibin Yuan, Jianan Yin, Jiahao Wu, Xinran Gao, Zhixin Zhu, Yan Zhang, Zichen Wang, He Huang, Guangbo Kang   +11 more
wiley   +1 more source

Transcriptional cross-activation between toxin-antitoxin systems of Escherichia coli [PDF]

, 2013
BACKGROUND: Bacterial toxin-antitoxin (TA) systems are formed by potent regulatory or suicide factors (toxins) and their short-lived inhibitors (antitoxins). Antitoxins are DNA-binding proteins and auto-repress transcription of TA operons.
Niilo Kaldalu, Tanel Tenson, Toomas Mets, Villu Kasari   +3 more
core   +1 more source

Phasins PhbP2 and PhbP3 Are Involved in the Depolymerization of Polyhydroxybutyrate in Azotobacter vinelandii

Journal of Basic Microbiology, Volume 65, Issue 12, December 2025.
ABSTRACT Polyhydroxybutyrate (PHB) is a natural polyester synthesized and stored intracellularly as cytoplasmic granules, serving as a carbon and energy reserve in certain bacteria. These granules are surrounded by a variety of proteins, including those directly involved in PHB metabolism—both in its synthesis and degradation—as well as a group of non ...
Jessica Ruiz‐Escobedo, Josefina Guzmán, Guadalupe Espín, Thalía Barrientos‐Millán, Andrea Moyao‐Mejía, Carlos Peña, Soledad Moreno, Erika P. Meneses‐Romero, Daniel Segura   +8 more
wiley   +1 more source

Genome‐Driven Analysis Reveals the Biotechnological Potential of a Novel Paenibacillus sp. Isolated From Crude Oil

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
The novel Paenibacillus sp. strain 210, isolated from Brazilian crude oil, its genome encoding 259 carbohydrate‐active enzymes for degrading cellulose, xylan, and pectin, positioning it as a candidate for biofuel production. The strain harbors complete pathways for B‐vitamin biosynthesis and antimicrobial biosynthetic clusters (e.g., fusaricidin and ...
João Victor dos Anjos Almeida, Carlos Miguel Nóbrega Mendonça, Leandro Marcio Moreira, Ricardo Pinheiro de Souza Oliveira, Alessandro de Mello Varani, Mauro de Medeiros Oliveira   +5 more
wiley   +1 more source

The role of small proteins in Burkholderia cenocepacia J2315 biofilm formation, persistence and intracellular growth [PDF]

, 2019
Burkholderia cenocepacia infections are difficult to treat due to resistance, biofilm formation and persistence. B. cenocepacia strain J2315 has a large multi-replicon genome (8.06 Mb) and the function of a large fraction of (conserved) hypothetical ...
Braeckmans, Kevin, Coenye, Tom, Crabbé, Aurélie, Daled, Simon, De Keersmaecker, Herlinde, Deforce, Dieter, Dhaenens, Maarten, Jurėnas, Dukas, Ostyn, Lisa, Sass, Andrea, Teirlinck, Eline, Van Acker, Heleen, Van Melderen, Laurence   +12 more
core   +1 more source

The Gfr Uptake System Provides a Context‐Dependent Fitness Advantage to Salmonella Typhimurium SL1344 During the Initial Gut Colonization Phase

Molecular Microbiology, Volume 124, Issue 6, Page 507-520, December 2025.
Diet–microbiota interactions shape colonization resistance. While the microbiota restricts pathogens like Salmonella through nutrient competition, Salmonella can exploit private nutrients such as fructoselysine (FL), abundant in processed foods but inaccessible to most microbes.
Lea Fuchs, Cora Lisbeth Dieterich, Elena Melgarejo Ros, Philipp Keller, Anna Sintsova, Leanid Laganenka, Thomas A. Scott, Christopher Schubert, Shinichi Sunagawa, Julia A. Vorholt, Jörn Piel, Wolf‐Dietrich Hardt, Bidong D. Nguyen   +12 more
wiley   +1 more source

A CRISPRi Gene Regulation System for Bifidobacteria

Microbial Biotechnology, Volume 18, Issue 11, November 2025.
We report the development of a single plasmid‐based CRISPR interference system based on a catalytically dead Cas9 from Streptococcus thermophilus for targeted gene repression in bifidobacteria. This system is capable of repressing genes in a diverse range of bifidobacteria enabling functional genomics studies in non‐model strains.
Lisa Friess, Douwe van Sinderen, Ciaran Lee   +2 more
wiley   +1 more source

16S rRNA based identification of _Aeromonas sp. kumar_ by constructing phylogenetic tree and identification of regulatory elements from the harmful Red Tide bloom, Gulf of Mannar [PDF]

, 2009
A bacterial strain, designated _Aeromonas sp. kumar_, was isolated from a water sample collected from Red tide Bloom occurred in the region of Gulf of Mannar region, Puthumadam Coast, India and the strain was identified using 16S rRNA based ...
A. K. Kumaraguru, C. M. Ramakritinan, P. Kumar   +2 more
core   +1 more source

Stabilization of the Virulence Plasmid pSLT of Salmonella Typhimurium by Three Maintenance Systems and Its Evaluation by Using a New Stability Test [PDF]

, 2016
Certain Salmonella enterica serovars belonging to subspecies I carry low-copy-number virulence plasmids of variable size (50–90 kb). All of these plasmids share the spv operon, which is important for systemic infection.
Díaz-Orejas, Ramón, García del Portillo, Francisco, Lobato-Márquez, Damián, Molina-García, Laura, Moreno-Córdoba, Inmaculada   +4 more
core   +2 more sources

Dissecting a complex chemical stress: chemogenomic profiling of plant hydrolysates. [PDF]

, 2013
The efficient production of biofuels from cellulosic feedstocks will require the efficient fermentation of the sugars in hydrolyzed plant material.
Arkin, Adam P, Bauer, Stefan, Baumohl, Jason K, Deutschbauer, Adam M, Hazen, Terry, Hu, Ping, Ibáñez, Ana B, Leon, Dacia, Mar, Jordan S, Mitchell, Valerie D, Price, Morgan N, Skerker, Jeffrey M, Tarjan, Daniel R, Wetmore, Kelly M, Wu, Cindy H   +14 more
core   +2 more sources