ABSTRACT Background and Aims Tuberculosis, caused by Mycobacterium tuberculosis (M. tuberculosis), is a highly contagious disease and one of the leading causes of mortality globally. The emergence and dissemination of multidrug‐resistant (MDR) strains of M. tuberculosis have become a major concern, especially in developing countries.
Ali Bayat Bodaghi +5 more
wiley +1 more source
Structurally robust biological networks [PDF]
Background: The molecular circuitry of living organisms performs remarkably robust regulatory tasks, despite the often intrinsic variability of its components.
Blanchini, Franco, Franco, Elisa
core +5 more sources
The global emergence of hypervirulent, carbapenem‐resistant Klebsiella pneumoniae (hvCRKP) poses a paradox: why do such dangerous clones remain geographically confined? By analyzing over 2500 CC23 genomes across 90 years, we uncover a core evolutionary constraint—virulence and resistance rarely coexist without trade‐offs. Potent carbapenemases (blaKPC,
Yuchen Wu +15 more
wiley +1 more source
Exploiting the Anaerobic Expression of Pyruvate Dehydrogenase for the Production of Biofuels
The Pyruvate dehydrogense complex (PDH) is a primarily aerobic enzyme which catalyses pyruvate to acetyl-CoA and carbon dioxide. Its counterpart in anaerobic metabolism is pyruvate formate lyase (Pfl) which converts pyruvate to acetyl-CoA and formate.
Crowhurst, Nicola, Crowhurst, Nicola
core +1 more source
Condition‐dependent resource allocation strategy governed by CodY regulator in Bacillus subtilis
Abstract To thrive in nature, bacteria have to rapidly proliferate in favorable conditions while constantly adapt to the fluctuating nutrient environments. However, the molecular players that ensure rapid growth of bacteria in favorable conditions remain poorly understood.
Haoyan Mu +5 more
wiley +1 more source
Mechanisms of polymyxin resistance: acquired and intrinsic resistance in bacteria [PDF]
Polymyxins are polycationic antimicrobial peptides that are currently the last-resort antibiotics for the treatment of multidrug-resistant, Gram-negative bacterial infections.
Morand, Serge +2 more
core +3 more sources
Identification of MscS as a Key L‐Glutamate Exporter in Bacillus methanolicus
l‐Glutamate export in the methylotrophic bacterium Bacillus methanolicus, driven by an MscS‐like mechanosensitive channel. Figure created with BioRender (https://BioRender.com/t99s28). ABSTRACT Small‐conductance mechanosensitive channels (MscS) are established l‐glutamate exporters in industrially relevant bacteria, yet their role in the methylotrophic
Luciana Fernandes Brito +5 more
wiley +1 more source
Engineering the Interface Between Cellular Chassis and Integrated Biological Systems [PDF]
The engineering of biological systems with predictable behavior is a challenging problem. One reason for this difficulty is that engineered biological systems are embedded within complex and variable host cells. To help enable the future engineering of
Canton, Bartholomew
core
Polysaccharide utilization loci and nutritional specialization in a dominant group of butyrate-producing human colonic Firmicutes [PDF]
Acknowledgements The Rowett Institute of Nutrition and Health (University of Aberdeen) receives financial support from the Scottish Government Rural and Environmental Sciences and Analytical Services (RESAS).
Bernalier-Donadille, Annick +9 more
core +3 more sources
Description of Treponema azotonutricium sp. nov. and Treponema primitia sp. nov., the First Spirochetes Isolated from Termite Guts [PDF]
Long after their original discovery, termite gut spirochetes were recently isolated in pure culture for the first time. They revealed metabolic capabilities hitherto unknown in the Spirochaetes division of the Bacteria, i.e., H2 plus CO2 acetogenesis (J.
Breznak, John A. +2 more
core +1 more source

