Results 61 to 70 of about 18,029 (193)

Mechanisms of Antibiotic Resistance and Novel Therapeutic Approaches for Mycobacterium tuberculosis: A Narrative Review With a Focus on Tuberculosis Mutations in Iran

open access: yesHealth Science Reports, Volume 8, Issue 10, October 2025.
ABSTRACT Background and Aims Tuberculosis, caused by Mycobacterium tuberculosis (M. tuberculosis), is a highly contagious disease and one of the leading causes of mortality globally. The emergence and dissemination of multidrug‐resistant (MDR) strains of M. tuberculosis have become a major concern, especially in developing countries.
Ali Bayat Bodaghi   +5 more
wiley   +1 more source

Structurally robust biological networks [PDF]

open access: yes, 2011
Background: The molecular circuitry of living organisms performs remarkably robust regulatory tasks, despite the often intrinsic variability of its components.
Blanchini, Franco, Franco, Elisa
core   +5 more sources

Geographic containment and virulence‐resistance trade‐offs drive the evolution of hypervirulent Klebsiella pneumoniae

open access: yesiMeta, Volume 4, Issue 5, October 2025.
The global emergence of hypervirulent, carbapenem‐resistant Klebsiella pneumoniae (hvCRKP) poses a paradox: why do such dangerous clones remain geographically confined? By analyzing over 2500 CC23 genomes across 90 years, we uncover a core evolutionary constraint—virulence and resistance rarely coexist without trade‐offs. Potent carbapenemases (blaKPC,
Yuchen Wu   +15 more
wiley   +1 more source

Exploiting the Anaerobic Expression of Pyruvate Dehydrogenase for the Production of Biofuels

open access: yes, 2012
The Pyruvate dehydrogense complex (PDH) is a primarily aerobic enzyme which catalyses pyruvate to acetyl-CoA and carbon dioxide. Its counterpart in anaerobic metabolism is pyruvate formate lyase (Pfl) which converts pyruvate to acetyl-CoA and formate.
Crowhurst, Nicola, Crowhurst, Nicola
core   +1 more source

Condition‐dependent resource allocation strategy governed by CodY regulator in Bacillus subtilis

open access: yesmLife, Volume 4, Issue 5, Page 539-550, October 2025.
Abstract To thrive in nature, bacteria have to rapidly proliferate in favorable conditions while constantly adapt to the fluctuating nutrient environments. However, the molecular players that ensure rapid growth of bacteria in favorable conditions remain poorly understood.
Haoyan Mu   +5 more
wiley   +1 more source

Mechanisms of polymyxin resistance: acquired and intrinsic resistance in bacteria [PDF]

open access: yes, 2014
Polymyxins are polycationic antimicrobial peptides that are currently the last-resort antibiotics for the treatment of multidrug-resistant, Gram-negative bacterial infections.
Morand, Serge   +2 more
core   +3 more sources

Identification of MscS as a Key L‐Glutamate Exporter in Bacillus methanolicus

open access: yesMicrobial Biotechnology, Volume 18, Issue 10, October 2025.
l‐Glutamate export in the methylotrophic bacterium Bacillus methanolicus, driven by an MscS‐like mechanosensitive channel. Figure created with BioRender (https://BioRender.com/t99s28). ABSTRACT Small‐conductance mechanosensitive channels (MscS) are established l‐glutamate exporters in industrially relevant bacteria, yet their role in the methylotrophic
Luciana Fernandes Brito   +5 more
wiley   +1 more source

Engineering the Interface Between Cellular Chassis and Integrated Biological Systems [PDF]

open access: yes, 2005
The engineering of biological systems with predictable behavior is a challenging problem. One reason for this difficulty is that engineered biological systems are embedded within complex and variable host cells. To help enable the future engineering of
Canton, Bartholomew
core  

Polysaccharide utilization loci and nutritional specialization in a dominant group of butyrate-producing human colonic Firmicutes [PDF]

open access: yes, 2015
Acknowledgements The Rowett Institute of Nutrition and Health (University of Aberdeen) receives financial support from the Scottish Government Rural and Environmental Sciences and Analytical Services (RESAS).
Bernalier-Donadille, Annick   +9 more
core   +3 more sources

Description of Treponema azotonutricium sp. nov. and Treponema primitia sp. nov., the First Spirochetes Isolated from Termite Guts [PDF]

open access: yes, 2004
Long after their original discovery, termite gut spirochetes were recently isolated in pure culture for the first time. They revealed metabolic capabilities hitherto unknown in the Spirochaetes division of the Bacteria, i.e., H2 plus CO2 acetogenesis (J.
Breznak, John A.   +2 more
core   +1 more source

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