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MELAS and l-arginine therapy

Mitochondrion, 2007
We investigated the endothelial function in MELAS patients and also evaluated the therapeutic effects of L-arginine. Concentrations of L-arginine during the acute phase of MELAS were significantly lower than in control subjects. L-arginine infusions significantly improved all symptoms suggesting stroke within 30 min, and oral administration ...
Yasutoshi, Koga   +6 more
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Bacterial electrode for l-arginine

Talanta, 1982
Streptococcus lactis bacterial cells are employed for the conversion of L-arginine into ammonia. An ammonia gas-electrode is used as a detector. The combination of bacterial action and the gas electrode responds linearly to L-arginine over the concentration range 8.0 x 10(-6) - 1.0 x 10(-3)M, with a slope of 59.0 mV/decade and is selective with respect
S R, Grobler, N, Basson, C W, Van Wyk
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L-Arginine Transport in Disease

Current Medicinal Chemistry-Cardiovascular & Hematological Agents, 2004
The importance of membrane transport in normal physiological cell function is unquestionable. However, to what extent alterations in the transport of amino acids are the cause and/or consequence of pathological changes observed in disease states is a question not yet completely clarified. Kinetic experiments with blood cells provide a simple and useful
Antônio Cláudio, Mendes Ribeiro   +1 more
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The l-arginine

Current Opinion in Nephrology and Hypertension, 1993
The L-arginine: nitric oxide pathway is widely recognized as an important regulator of cell function and communication in a variety of physiological and pathophysiological situations. Recent advances in the biochemistry and molecular biology of nitric oxide synthases have contributed significantly to our understanding of the regulation of nitric oxide ...
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The l-arginine paradox: Importance of the l-arginine/asymmetrical dimethylarginine ratio

Pharmacology & Therapeutics, 2007
Cardiovascular diseases (CVD) are still the most frequent cause of death in Western Europe. Pathophysiological experiments revealed in the last years that the vascular endothelium, as well as a result of the synthesis of nitric oxide (NO), is a crucial regulator of vascular function and homeostasis.
Stefanie M, Bode-Böger   +2 more
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Formyl-l-arginine monohydrate

Journal of Molecular Structure, 2007
Abstract A new compound Nα-formyl- l -arginine +(H2N)2CNH(CH2)3CH(HN(HCO))COO− with zwitter-ionic structure has been found out in the system l -arginine + HCOOH + H2O. The title compound crystallizes in monoclinic system (space group P21) as monohydrate.
H.A. Karapetyan   +3 more
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The Clinical Pharmacology of L-Arginine

Annual Review of Pharmacology and Toxicology, 2001
L-Arginine (2-amino-5-guanidinovaleric acid) is the precursor of nitric oxide, an endogenous messenger molecule involved in a variety of endothelium-mediated physiological effects in the vascular system. Acute and chronic administration of L-arginine has been shown to improve endothelial function in animal models of hypercholesterolemia and ...
R H, Böger, S M, Bode-Böger
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Vibrational spectra of l-arginine tetrafluoroborate and l-arginine perchlorate

Vibrational Spectroscopy, 2006
Abstract Attenuated total reflection Fourier transform infrared (FT-IR ATR) and Fourier transform Raman spectra of l -arginine tetrafluoroborate ( l -Arg.HBF 4 ) and l -arginine perchlorate ( l -Arg.HClO 4 ) crystals are reported and discussed. The FT-IR ATR spectrum of l -Arg.HClO 4 is in agreement with previously published FT-IR KBr pellet ...
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Preparation of NG-monoethyl-l-arginine

Analytical Biochemistry, 1984
NG-Monoethyl-L-arginine, a putative in vivo product after administration of the potent hepatocarcinogen L-ethionine to rats, has been chemically synthesized by coupling N-ethyl, S- methylthiopseudouronium iodide with alpha-amino-blocked L-ornithine. The structure of the compound as NG-monoethyl-L-arginine was confirmed by 13C NMR.
Y B, Cho, G, Furst, W K, Paik
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L-Arginine as an Antihypertensive Agent

Journal of Cardiovascular Pharmacology, 1992
L-Arginine, the precursor of endothelium-derived relaxing factor (EDRF)/nitric oxide (NO), was administered intravenously in five patients with essential hypertension, one with renovascular hypertension, one with primary aldosteronism, and one with Cushing's syndrome. During the administration, the mean arterial pressure decreased concomitantly with an
K, Hishikawa   +4 more
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