Results 171 to 180 of about 16,350,711 (297)

A Novel Reactive Oxygen Species‐Responsive Bone‐Targeted Nanoplatform Based on Cloperastine Attenuates Ovariectomy‐Induced Bone Loss by Inhibiting Osteoclast Oxidative Phosphorylation

Advanced Science, EarlyView.
Cloperastine suppresses osteoclastogenesis by inhibiting PGC1β‐mediated oxidative phosphorylation. Its incorporation into a ROS‐responsive, Asp8‐modified nanoplatform enhances skeletal accumulation. The resulting Clo/Asp8‐PMK‐MCs combine cloperastine‐mediated antiresorptive activity with carrier‐mediated osteogenic activity to attenuate OVX‐induced ...
Haibo Liang, Yong Xiao, Jiangtao Luo, Xiao Yang, Yayun Yang, Qihang Wu, Chenxin Yu, Zhihao Zhou, Xiaoqing Si, Jiansen Miao, Yiting Tu, Qichen Lu, Boreng Qian, Xiangyang Wang, Jiake Xu, Changcan Shi, Haiming Jin   +16 more
wiley   +1 more source

The transcription factor AebHLH89 activates <i>AeGMP1</i> transcription to regulate L-ascorbic acid accumulation in kiwifruit (<i>Actinidia eriantha</i>) revealed by genome-wide association study. [PDF]

Hortic Res
Chen L, Jia D, Liu Y, Gao H, Liao G, Mao J, Gao Z, Xu X.   +7 more
europepmc   +1 more source

Effects of L-ascorbic acid on growth, non-specific immunity, antioxidant capacity, and intestinal and hepatopancreatic histology of red swamp crayfish, Procambarus clarkii. [PDF]

Sci Rep, 2023
Khalil HS, Ahmed HO, Elkhouly N, El Basuini MF, El-Nokrashy AM, Hessein AAA, Khaled AA, Rashad AMA, Kord M, Alkenawy D, Abdel-Tawwab M, Abdel-Latif HMR.   +11 more
europepmc   +1 more source

One‐Step Induction of Oogonia‐Like and Pro‐Spermatogonia‐Like Cells From Porcine Pluripotent Stem Cells

Advanced Science, EarlyView.
This study established a one‐step method inducing pro‐spermatogonia‐like (activating SOX17) and oogonia‐like (activating SOX17/TFAP2C) cells from porcine pgEpiSCs with a NANOS3‐tdTomato reporter. EGF activates the core PGC program and supports survival; BMP4 further induces NANOS3 and DDX4 expression; IWR1 enhances PGCLC efficiency by suppressing ...
Pengcheng He, Liang Zhong, Tianzhi Chen, Yaxuan Yan, Xinze Chen, Runbo Li, Yingjie Wang, Yadi Teng, Minglei Zhi, Meng Wang, Jinying Zhang, Fan Zhao, Dengfeng Gao, Suying Cao, Jianyong Han   +14 more
wiley   +1 more source

L-Ascorbic acid preferentially kills KRAS mutant pancreatic cancer cells through DNA damage. [PDF]

Sci Rep
Jang HL, Kim ST, Hong JY, Jang KT, Heo J, Chon HJ, Park YS, Park JO.   +7 more
europepmc   +1 more source

Derivatives of L-Ascorbic Acid in Emulgel: Development and Comprehensive Evaluation of the Topical Delivery System. [PDF]

Pharmaceutics, 2023
Stolić Jovanović A, Martinović M, Žugić A, Nešić I, Tosti T, Blagojević S, Tadić VM.   +6 more
europepmc   +1 more source

L-ascorbic acid degradation by bacteria. I. Mechanism of L-ascorbic acid degradation.

The Journal of vitaminology, 1960
openaire   +2 more sources

Lithium‐Doped Hydroxyapatite Nanowires Rejuvenate Senescent Macrophages Via the Lysosome‐Dependent Ferroptosis Axis to Promote Aged Bone Regeneration

Advanced Science, EarlyView.
Li‐nHAP+GelMA promotes mandibular bone regeneration in aged mice by remodeling the senescent immune microenvironment. Local delivery of Li‐nHAP restores lysosomal homeostasis in senescent macrophages, reduces intracellular labile Fe2+ accumulation, ROS production, and lipid peroxidation, thereby suppressing macrophage ferroptosis and senescence ...
Baixi Chen, Ziduan Ding, Ruomei Li, Cheng Zhu, Zhiyu Zhu, Zitong Yang, Luyao Qu, Jin Hao, Lunguo Xia, Bing Fang, Lu Liu   +10 more
wiley   +1 more source

Impact of the Use of 2-Phospho-L Ascorbic Acid in the Production of Engineered Stromal Tissue for Regenerative Medicine. [PDF]

Cells
Brownell D, Carignan L, Alavi R, Caneparo C, Labroy M, Galbraith T, Chabaud S, Berthod F, Gibot L, Bordeleau F, Bolduc S.   +10 more
europepmc   +1 more source

Effects of the In Ovo Injection of L-Ascorbic Acid on Broiler Hatching Performance. [PDF]

Animals (Basel), 2022
Mousstaaid A, Fatemi SA, Elliott KEC, Alqhtani AH, Peebles ED.   +4 more
europepmc   +1 more source