Results 161 to 170 of about 16,350,711 (297)

3D Bioprinted Blood–Brain–Tumor Barrier Spheroid‐Based In Situ Evaluation of Anticancer Compounds Against Glioblastoma: ROS‐Producing Ruthenium as a Potential Therapeutic Candidate

Advanced Science, EarlyView.
The blood–brain–tumor barrier (BBTB) penetration by anticancer drugs and their effects on glioblastoma (GBM) is assessed using 3D bioprinted‐spheroids. Anticancer drug‐induced U‐87 MG cell death is quantified through in situ imaging of spheroids using a cancer cell death probe. The Ru compound, a partial P‐gp substrate, induces greater tumor‐cell death
Hyunjung Lee, Chan Ho Jeon, Doyun Kim, Minjae Lee, Minji Kwon, Joon Myong Song   +5 more
wiley   +1 more source

Effects of L-ascorbic acid as an additive for improving the physical properties and setting behavior of fabricated calcium silicate cement. [PDF]

J Dent Sci
Park YJ, Seo H, Song YH, Choi WY, Umugire A, Ryu H, Song HJ, Park YJ.   +7 more
europepmc   +1 more source

Effects of the In Ovo and Dietary Supplementation of L-Ascorbic Acid on the Growth Performance, Inflammatory Response, and Eye L-Ascorbic Acid Concentrations in Ross 708 Broiler Chickens. [PDF]

Animals (Basel), 2022
Mousstaaid A, Fatemi SA, Elliott KEC, Levy AW, Miller WW, Gerard PD, Alqhtani AH, Peebles ED.   +7 more
europepmc   +1 more source

Metabolic‐Redox Remodeling of Inflammatory Synovium by Mannose‐Modified Selenium Nanoparticles for Osteoarthritis Therapy

Advanced Science, EarlyView.
Elevated GLUT1‐driven glycolysis and disrupted selenoprotein‐dependent redox homeostasis drive osteoarthritic progression. Intra‐articular mannose‐modified selenium nanoparticles (M‐SeNPs) selectively target hypermetabolic synovial cells to reprogram aberrant glycolysis and restore endogenous antioxidant defenses.
Yu‐Qing Zou, Chen‐Hao Xu, Bo‐Wei Li, Leung Chan, Yi‐Di Xu, Han‐Bo Su, Rui Peng, Fang‐Ji Luo, Ya‐Chen Peng, Zhen‐Yan Li, Vincent Kam Wai Wong, Xiao‐Fei Zheng, Xing Ma, Zhen‐Gang Zha, Tianfeng Chen, Huan‐Tian Zhang   +15 more
wiley   +1 more source

L-Ascorbic Acid 2-Phosphate-Releasing Poly(trimethylene carbonate) Increases Cell Proliferation and Collagen Production: A Novel Material for Pelvic Organ Prolapse Tissue Engineering. [PDF]

Tissue Eng Regen Med
Ala-Mononen K, Grijpma D, Efimov A, Mustakoski S, Kuismanen K, Miettinen S, Sartoneva R.   +6 more
europepmc   +1 more source

Wafer‐Scale Dendritic Nanoporous Platinum Films for Neural Electrodes

Advanced Science, EarlyView.
Wafer‐scale dendritic nanoporous platinum films with intrinsic nanoscale porosity are synthesized by suraface‐confined wet chemistry and transferred onto flexible substrates to create tissue‐conformal neural electrodes. The ultrathin films combine mechanical flexibility with electrochemical stability, enabling low‐impedance, high‐capacitance interfaces
Kyeongbin Kang, Joosung Oh, Soumen Dutta, Sun Woo Jang, Byeong Su Gu, Woosung Cho, Mingyu Kwak, Sunguk Hong, Seongjae Lee, Hyo Kyoung Jeon, Juwan Han, Keehoon Kim, Sung‐Min Park, Unyong Jeong, In Su Lee   +14 more
wiley   +1 more source

Exogenous 2-Keto-L-Gulonic Acid Supplementation Promotes L-Ascorbic Acid Biosynthesis in <i>Drosophila melanogaster</i>. [PDF]

Int J Mol Sci
Meng C, Xu H.
europepmc   +1 more source

L-Ascorbic acid degradation by bacteria. VIII. All the pathway in the L-ascorbic acid metabolism.

The Journal of vitaminology, 1961
KAMIYA, SHINTARO, NAKABAYASHI, TOSHIO
openaire   +2 more sources

Age‐Related Lamin B1 Deficiency Activates SLC7A11‐Dependent Disulfidptosis to Impair Osteogenesis via Intercepting Mitochondrial Fission

Advanced Science, EarlyView.
This study reveals that age‐related LMNB1 deficiency in mesenchymal stem cells epigenetically upregulates SLC7A11, triggering actin disulfidptosis and mitochondrial dysfunction. This cascade impairs bone formation in senile osteoporosis. Furthermore, researchers identified the FDA‐approved drug naldemedine as a targeted SLC7A11 inhibitor to reverse ...
Wenhui Yu, Qibo Li, Weihao Zhang, Guan Zheng, Junhua Chen, Yipeng Zeng, Zipeng Xiao, Zibin Chen, Ziqian Liu, Yangfeng Lin, Jiajie Lin, Zepeng Su, Zhongyu Xie   +12 more
wiley   +1 more source

Molecular mechanisms of high levels of L-ascorbic acid accumulation in chestnut rose fruits. [PDF]

Plant Commun
Li Y, Liu Z, Liao G, Huang Y, Liu S, Liu X, Wang S, Liu B, He C, Yang K, Xu Y, Zuo H, Fu J, Song L, Li R, Zheng Q, Zhang F, Lin Z, Ning G, Xie Z, Deng X, Wang X, Xu Q.   +22 more
europepmc   +1 more source