Results 251 to 260 of about 268,588 (307)

Pharmacogenetic CYP2B6 variants affect steroid hormone metabolism in human breast cancer cells

British Journal of Clinical Pharmacology, EarlyView.
Common genetic CYP2B6 variants correlate with adverse breast cancer outcome. The oestrogen metabolites estriol and 16‐epiestriol, which are formed downstream of CYP2B6‐catalysed 16α/β‐hydroxytestosterone, may be linked to elevated breast cancer risk and might increase due to the demonstrated CYP2B6 variants‐related metabolic shifts.
Marco Hoffmann, Julian Peter Müller, Stefan Düsterhöft, Sabrina Yamoune, Katja Susanne Just, Julia Carolin Stingl   +5 more
wiley   +1 more source

Vitamins as potent cancer treatments through regulating the activity and expression of MMP‐2 and MMP‐9

Bulletin of the Korean Chemical Society, EarlyView.
Vitamins could regulate both MMP‐2 and MMP‐9 expression and activity through transcriptional and MAPK signaling pathway modulation. This study highlights the potential of vitamins as low‐toxicity therapeutic or adjunct agents for targeting MMP‐mediated cancer progression. Abstract Matrix metalloproteinases (MMP‐2 and MMP‐9) are key regulators of cancer
Yen Thi Nguyen, Eungchan Kim, Ha Vy Thi Vo, Song Ja Kim, Namdoo Kim, Hyuck Jin Lee   +5 more
wiley   +1 more source

Toward personalized healthcare: Advances in two‐dimensional nanomaterial‐based flexible electrochemical sensors for physiological monitoring

BMEMat, EarlyView.
This review provides an overview of the properties, composites and application of two‐dimensional (2D) nanomaterials for wearable electrochemical biosensors. Also, the challenges and future prospects of utilizing 2D nanomaterials in wearable electrochemical biosensor applications are discussed.
Kou Zhang, Lu Han, He‐Qing Cai, Xin‐Yu Xue, Yi‐Fei Song, Wu‐Lin Xin, Ying‐Ze Wang, Peng Liu, Juan Liu   +8 more
wiley   +1 more source

[L-ascorbic acid 2-sulphate].

Postepy biochemii, 1983
openaire   +1 more source

Lysosomes and L-ascorbic acid

, 1980
openaire   +1 more source

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Topical L-Ascorbic Acid

Dermatologic Surgery, 2001
Reactive oxygen species generated by ultraviolet light result in photocarcinogenic and photoaging changes in the skin. Antioxidants protect skin from these insults.This study defines formulation characteristics for delivering L-ascorbic acid into the skin to supplement the skin's natural antioxidant reservoir.L-ascorbic acid or its derivatives were ...
S R, Pinnell, H, Yang, M, Omar, N, Monteiro-Riviere, H V, DeBuys, L C, Walker, Y, Wang, M, Levine   +7 more
openaire   +2 more sources

Synthesis of L-Ascorbic Acid

1980
Publisher Summary This chapter provides a summary of the methods developed for the synthesis of L-ascorbic acid. L -Ascorbic acid is a white, crystalline solid melting at 192°C and having, in water, a specific rotation at the sodium D line of +24°. In solution, L -ascorbic acid has a pK 1 of 4.17 and a pK 2 of 11.79.
T C, Crawford, S A, Crawford
openaire   +2 more sources

Transglycosylation of L-ascorbic acid

Applied Biochemistry and Microbiology, 2007
Cyclodextrin glucanotransferases (CGTs, EC 2.4.1.19) from mesophilic, thermophilic, and halophilic bacteria and maltase (EC 3.2.1.20) from the yeast Saccharomyces cerevisiae were used for transglycosylation of ascorbic acid with starch, maltodextrin, γ-cyclodextrin, and maltose. These compounds served as donors of glucosyl residues.
A. A. Markosyan, L. A. Abelyan, M. O. Adamyan, Zh. I. Akopyan, V. A. Abelyan   +4 more
openaire   +3 more sources

An efficient synthesis of L-ascorbic acid and [5-2H1]-L-ascorbic acid

Journal of the Chemical Society, Chemical Communications, 1979
L-Ascorbic acid has been synthesized via the regio- and stereo-selective reduction of D-threo-2,5-hexodiulosonic acid; this procedure also can be used for preparation of the 5-deuterio-compound.
Glenn Andrews, Bradley Bacon, Thomas Crawford, Ralph Breitenbach   +3 more
openaire   +1 more source