Results 161 to 170 of about 14,268,580 (205)

Clinical Experience with L-Asparaginase

1970
Three sources of L-asparaginase, two derived from E. coli (supplied by E. R. Squibb and Farbenfabriken Bayer AG), and one obtained from Erwinia carotovora (supplied by the Microbiological Research Establishment, Porton) have been made available to us and have been used in the treatment of acute myeloid leukemia, acute lymphoblastic leukemia ...
G, Hamilton-Fairley, J S, Malpas, D A, Galton   +2 more
  +7 more sources

Partially deaminated L-asparaginase

Biochemical and Biophysical Research Communications, 1969
Partially deaminated l-asparaginase.. M3A. Or "asparaginase X", made by heating the enzyme 1-asparaginase (I) with nitrous acid or a cpd. furnishing nitrous acid, gives increased blood serum titres.
O, Wagner, E, Irion, A, Arens, K, Bauer
openaire   +2 more sources

Embryotoxic Effect of L-Asparaginase

Nature, 1968
L-Asparaginase catalyses the hydrolysis of L-asparagine to L-aspartic acid and ammonia. Interest in this enzyme has been stimulated by the discovery that it inhibits the growth of several experimental tumours1–3. L-Asparaginase is being used clinically to treat various leukaemias, lymphomas arid melanomas4, and it was recently shown to inhibit the ...
R H, Adamson, S, Fabro
openaire   +2 more sources

On the distribution of plasma L-asparaginase

Experientia, 1983
The guinea-pig, Cavia porcellus, is unusual in possessing plasma L-asparaginase, an enzyme with anti-tumor activity, 21 additional species have been examined as to the presence of this enzyme: the results confirm and extend its remarkably limited species distribution.
E, Yurek, D, Peru, J C, Wriston
openaire   +2 more sources

L-Asparaginase

Annual Review of Medicine, 1970
R L, Capizzi, J R, Bertino, R E, Handschumacher   +2 more
  +7 more sources

Experimental Immunosuppression with L-Asparaginase

1970
During the last year several papers were published dealing with an immunosuppressive action of Escherichia coli L-asparaginase. Hobik described the inhibition of the graft-versus-host reaction in rats and mice. Bertelli, Donati and Trabucchi, using very high doses of L-asparaginase, found a prolongation of the rejection time of allogeneic and ...
K, Lauenstein, E, Grundmann, H P, Hobik, W P, Madaus   +3 more
openaire   +2 more sources

Polyethylene glycol-L-asparaginase and L-asparaginase studies in rabbits.

Drug Metabolism and Disposition, 1988
Injections of polyethylene glycol (PEG)-L-asparaginase or L-asparaginase were given to two rabbits each at doses of 40 units/kg. Ten min following injection of either enzyme preparation, the plasma enzyme concentration was approximately 1 unit/ml. This level decreased steadily in the rabbits given L-asparaginase, with a t1/2 of approximately 20 hr.
D H, Ho, C Y, Wang, J R, Lin, N, Brown, R A, Newman, I H, Krakoff   +5 more
openaire   +2 more sources

L-Asparaginase

2022
L-Asparaginase (ASNase, EC 3.5.1.1) is a tetrameric aminohydrolase enzyme that catalyses the hydrolysis of the amino acid L-Asparagine into ammonia and L-aspartic acid. ASNase is present in different organisms such as bacteria, fungi, plant tissues and algae.
Tavares, Ana Paula, Nunes, João C. F., Cristóvão, Raquel, Freire, Mara, Santos-Ebinuma, Valéria, Faria, Joaquim Luís, Silva, Cláudia   +6 more
openaire   +1 more source

Antiviral Activity of L-Asparaginase

Nature New Biology, 1971
L-ASPARAGINASE has anti-leukaemic and immunosuppressive activities1 and following the observation that L-asparaginase inhibits plaque formation in L mouse fibroblast cultures by herpes simplex virus2, we report studies of the activity of the enzyme on the multiplication of several human and animal viruses in cell cultures. A preparation of L-asparagine-
R, Maral, G H, Werner
openaire   +2 more sources

Monoclonal antibodies to L-asparaginase

Experientia, 1984
Five hybridomas secreting monoclonal antibody to E. coli L-asparaginase were isolated. These monoclonal antibodies were classified into 3 different subclasses; Ig G1 (1 clone), Ig G2 (2 clones) and Ig G3 (2 clones). One of them possessed anti-L-asparaginase neutralizing activity.
Kitao, T, Hattori, K
openaire   +2 more sources