Results 181 to 190 of about 10,199,072 (234)

L-Asparaginase and Complement

Nature, 1971
L-ASPARAGINASE, widely regarded as a potential oncolytic agent1–6, is known to depress both cellular and humoral immunity. Our investigation of the effect of L-asparaginase on the complement system, described in what follows, reveals a more complicated interaction—the enzyme inhibits the complement in whole serum in vitro but is a potent activator of ...
J M, Delage, J, Simard, G, Lehner-Netsch, A, Barry   +3 more
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Immunosuppression by L-Asparaginase

Nature, 1969
IN 1953 Kidd1 discovered that the growth of certain murine lymphomas is inhibited by the administration of guinea-pig serum. Broome2 found the suppressive factor to be L-asparaginase, an enzyme widely distributed in nature but present in serum only in guinea-pigs and in rodents of the superfamily Cavioidea3.
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Immunosuppression by L-Asparaginase

Nature, 1970
L-ASPAHAGINASE, an enzyme which occurs in the serum of certain rodents and is produced by various microorganisms, catalyses the hydrolysis of asparagine to L-aspartic acid and ammonia. It has been found useful in the treatment of acute lymphoblastic leukaemia and in occasional cases of other types of neoplasm in man1.
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L-ASPARAGINASE AND BLASTOGENESIS

The Lancet, 1969
T J, McElwain, S K, Hayward
  +12 more sources

Clinical Experience with L-Asparaginase

1970
Three sources of L-asparaginase, two derived from E. coli (supplied by E. R. Squibb and Farbenfabriken Bayer AG), and one obtained from Erwinia carotovora (supplied by the Microbiological Research Establishment, Porton) have been made available to us and have been used in the treatment of acute myeloid leukemia, acute lymphoblastic leukemia ...
G, Hamilton-Fairley, J S, Malpas, D A, Galton   +2 more
  +7 more sources

Partially deaminated L-asparaginase

Biochemical and Biophysical Research Communications, 1969
Partially deaminated l-asparaginase.. M3A. Or "asparaginase X", made by heating the enzyme 1-asparaginase (I) with nitrous acid or a cpd. furnishing nitrous acid, gives increased blood serum titres.
O, Wagner, E, Irion, A, Arens, K, Bauer
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Embryotoxic Effect of L-Asparaginase

Nature, 1968
L-Asparaginase catalyses the hydrolysis of L-asparagine to L-aspartic acid and ammonia. Interest in this enzyme has been stimulated by the discovery that it inhibits the growth of several experimental tumours1–3. L-Asparaginase is being used clinically to treat various leukaemias, lymphomas arid melanomas4, and it was recently shown to inhibit the ...
R H, Adamson, S, Fabro
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Polyethylene glycol-L-asparaginase and L-asparaginase studies in rabbits.

Drug Metabolism and Disposition, 1988
Injections of polyethylene glycol (PEG)-L-asparaginase or L-asparaginase were given to two rabbits each at doses of 40 units/kg. Ten min following injection of either enzyme preparation, the plasma enzyme concentration was approximately 1 unit/ml. This level decreased steadily in the rabbits given L-asparaginase, with a t1/2 of approximately 20 hr.
D H, Ho, C Y, Wang, J R, Lin, N, Brown, R A, Newman, I H, Krakoff   +5 more
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Experimental Immunosuppression with L-Asparaginase

1970
During the last year several papers were published dealing with an immunosuppressive action of Escherichia coli L-asparaginase. Hobik described the inhibition of the graft-versus-host reaction in rats and mice. Bertelli, Donati and Trabucchi, using very high doses of L-asparaginase, found a prolongation of the rejection time of allogeneic and ...
K, Lauenstein, E, Grundmann, H P, Hobik, W P, Madaus   +3 more
openaire   +2 more sources