Results 101 to 110 of about 1,567,546 (339)

Radiation‐Induced Tumor‐Intrinsic LTβR N‐Glycosylation Suppresses Pyroptosis Through TRIM28‐Mediated PCBP2 SUMOylation to Promote Gastric Cancer Radioresistance

Advanced Science, EarlyView.
Radiotherapy triggers LTβR N‐glycosylation, enhancing its overall protein stability and nuclear retention. This accumulation drives TRIM28‐mediated PCBP2 SUMOylation, suppressing pyroptosis and conferring gastric cancer radioresistance. Therapeutically, a targeted nanoplatform (cRGD‐Lipo@EMD) effectively disrupts this regulatory axis, offering a highly
Weijie Zang, Yunlong Ji, Chunwang Zhou, Xiwen Li, Zhuang Lu, Guangze Zhang, Yu Chen, Wanjiang Xue, Yilin Hu   +8 more
wiley   +1 more source

Sound‐Based Assembly of Magnetically Actuated Soft Robots Toward Enhanced Release of Extracellular Vesicles

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
Magnetic soft robots offer promise in biomedicine due to their wireless actuation and rapid response, but current fabrication methods are complex and have limited cellular compatibility. A new, contactless bioassembly strategy using hydrodynamic instabilities is introduced, enabling customizable, centimeter‐scale robots.
Wei Gao, Riccardo Tognato, Micaela Natta, Elena Della Bella, Alessandro Cianciosi, Tiziano Serra   +5 more
wiley   +1 more source

Nucleophilic Additions of 2-Furyllithium to Carbonyl Derivatives of L-Serine. Formal Synthesis of (2R,3R)-β-Hydroxy Aspartic Acid

Molecules, 1998
The nucleophilic addition of 2-furyllithium to esters derived from L-serine is described. The obtained furyl ketone 5 is stereoselectively reduced (ds≥95%) with sodium borohydride to afford the corresponding syn aminoalcohol 12 in enantiomerically ...
T. Tejero, F. L. Merchan, S. Franco, P. Merino   +3 more
doaj   +1 more source

Isolation of Aspartic Acid Using Novel Poly(2-hydroxyethyl methacrylate-N-methacryloyl-(l)-lysine) Cryogels

, 2017
In this study, we report on the synthesis of novel poly(2-hydroxyethyl methacrylate-N-methacryloyl-(l)-lysine) [poly(HEMA-MAL)] cryogels for the isolation of aspartic acid.
Aytekin Uzunoğlu, Kadir Erol, Uzunoğlu, Aytekin, Büşra Sarıca, Dursun Ali Köse, Erol, Kadir, Sarıca, Büşra, Kazım Köse, Köse, Kazım, Köse, Dursun Ali   +9 more
core   +1 more source

35 Individuals With HUWE1‐Related Neurodevelopmental Disorder and Suggested Clinical Evaluations

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT HUWE1 (HECT, UBA, and WWE Domain Containing E3 Ubiquitin Protein Ligase1, OMIM 300697), located at Xp11.22, encodes a ubiquitin ligase that is highly conserved across species. Genetic variants in HUWE1 described in multiple independent studies cause X‐linked intellectual disability, including in the patients identified by Juberg, Marsidi, and ...
Mindy H. Li, Deziree L. Coleman, Kelsey Hogan, Danielle Luz, Lindsay Bhandari, Newell Belnap, Tiffany Busa, Charles Coutton, Klaus Dieterich, Svetlana Gorokhova, Clara Hildebrandt, Rachel Logan, Milena Mariani, Manuela Morleo, Vincenzo Nigro, John Pappas, Rachel Rabin, Kelly Schoch, Angelo Selicorni, Vandana Shashi, Rebecca Spillmann, Jennifer Sullivan, Charlotte Tardy, Samantha A. Schrier Vergano, Brock Grill, Kristin Baranano   +25 more
wiley   +1 more source

Amino acid sequence of a soybean (Glycine max) seed polypeptide having a poly(L-aspartic acid) structure.

Journal of Biological Chemistry, 1987
A polypeptide of Mr 4400 was isolated from soybean (Glycine max) seeds by extraction with 60% ethanol followed by ion-exchange and reverse-phase chromatography.
S. Odani, T. Koide, T. Ono
semanticscholar   +1 more source

Microbial sensors for L-aspartic acid and urea.

BUNSEKI KAGAKU, 1990
アスパラギン酸センサーは,L-アスパラギン酸β-デカルボキシラーゼ活性をもつPseudomonas dacunhae をκ-カラギーナンで固定化した膜と二酸化炭素電極を組み合わせて作製した.このセンサーは0.2～5mMの濃度範囲で直線性を示し,安定性及び選択性も優れていた.このセンサーによる測定値は他の方法によるものとよい相関を示した.尿素センサーはウレアーゼ活性をもつSporosarcina ureae膜をP. 5ン粥膨伽卿欄6膜を君dacunhaeの場合と同じ方法で調製したものを,アンモニアガス電極に取り付けて作製した.このセンサーは0.1～50mMの範囲で直線性を示し,安定性及び選択性も優れていた.
MORIMOTO, Tomoaki, NAKAGAWA, Yoshimi, SENUMA, Masaru, TOSA, Tetsuya   +3 more
openaire   +2 more sources

Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles

Advanced NanoBiomed Research, EarlyView.
This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley   +1 more source

Poly(L-Lactic Acid-Co-Aspartic Acid): Interactive Polymers for Tissue Engineering

, 1995
One of the challenges in the field of tissue engineering is the development of optimal materials for use as scaffolds to support cell growth and tissue development.
Robert Langer, Noah Lotan, Jean Ou, Jeffrey S. Hrkach   +3 more
core   +1 more source

Clinical impacts of the concomitant use of L-asparaginase and total parenteral nutrition containing L-aspartic acid in patients with acute lymphoblastic leukemia. [PDF]

Front Nutr, 2023
Ko M, Kim MG, Yoon SS, Kim IW, Suh SY, Cho YS, Oh JM.   +6 more
europepmc   +1 more source