Results 111 to 120 of about 15,313,595 (281)

Unraveling A4GALT Mechanism and Its Modulation With Adamantyl‐Galactosylceramide Analogues: Advancing Fabry Disease Therapeutic Strategies

Angewandte Chemie, EarlyView.
A 310‐helix‐mediated conformational switch promotes a front‐face SNi‐like catalysis by human A4GALT. Mechanism‐guided design identifies AdaGalCer as a selective modulator of globotriaosylceramide (Gb3) biosynthesis, opening a clear route toward new Fabry disease therapeutics.
Nicky de Koster, Òscar Vidal‐Gironès, Rowan de Graaf, Ken Kok, Lindsey T. Lelieveld, Jackelien Hoogervorst, Maria J. Ferraz, José Pablo Rivas‐Fernández, Rob F. Lammers, Herman S. Overkleeft, Johannes M. F. G. Aerts, Rolf G. Boot, Carme Rovira, Marta Artola   +13 more
wiley   +2 more sources

Zeolite NaP1 Functionalization for the Sorption of Metal Complexes with Biodegradable N-(1,2-dicarboxyethyl)-D,L-aspartic Acid. [PDF]

Materials (Basel), 2021
Kołodyńska D, Ju Y, Franus M, Franus W.   +3 more
europepmc   +1 more source

Comparative analysis of TP53 gene in Tupaia belangeri subspecies (Tupaia belangeri yaoshanensis vs. Tupaia belangeri chinensis) and identification of mutations in spontaneous tumor cases

Animal Models and Experimental Medicine, EarlyView.
This study provides the first evidence of natural TP53 variation between tree shrew subspecies and identifies somatic TP53 mutations in spontaneous tree shrew sarcomas. The high structural and functional conservation of tree shrew p53 with humans supports its utility as a relevant model for TP53‐related cancer research.
Yingying Cao, Haibo Tang, Liang Liang, Jing Leng, Weijian Huang   +4 more
wiley   +1 more source

The Effects of Aspartic Acid on Some Physiological and Cytogenetical Parameters in Allium cepa L. Seeds Germinated under Salt Stress

Растениевъдни науки, 2020
The effects of aspartic acid on the seed germination, seedling growth (radicle lenght, radicle number and fresh weight), mitotic index and chromosome aberrations of Allium cepa L. germinated under saline conditions were examined in this study.
Kürşat Çavuşoğlu, İlknur Mercan, Dilek Çavuşoğlu   +2 more
doaj  

Isolation of Aspartic Acid Using Novel Poly(2-hydroxyethyl methacrylate-N-methacryloyl-(l)-lysine) Cryogels

, 2017
In this study, we report on the synthesis of novel poly(2-hydroxyethyl methacrylate-N-methacryloyl-(l)-lysine) [poly(HEMA-MAL)] cryogels for the isolation of aspartic acid.
Aytekin Uzunoğlu, Kadir Erol, Uzunoğlu, Aytekin, Büşra Sarıca, Dursun Ali Köse, Erol, Kadir, Sarıca, Büşra, Kazım Köse, Köse, Kazım, Köse, Dursun Ali   +9 more
core   +1 more source

Urine metabolomics in rats after administration of ketamine

Drug Design, Development and Therapy, 2015
Congcong Wen,1 Meiling Zhang,2 Jianshe Ma,2 Lufeng Hu,3 Xianqin Wang,2 Guanyang Lin31Laboratory Animal Centre, 2Analytical and Testing Center, 3First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of ChinaAbstract: In
Wen C, Zhang M, Ma J, Hu L, Wang X, Lin G   +5 more
doaj  

Synthesis of (3R)- and (3S)-3,4-Diamino-Butyric Acid from L-Aspartic Acid

, 1992
A short and convenient synthesis for both enantiomers of GABOB amino-analogue is reported, starting from L-aspartic acid.
Santaniello M, ZAPPIA, GIOVANNI, Misiti D   +2 more
core   +1 more source

Introduction of the N-Phthaloyl Group into Heat-Sensitive Amino Acid Derivatives; N-Phthaloyl-L-Aspartic Acid* [PDF]

, 1957
A method is described by which heat-sensitive amino acid derivatives can be converted to unracemized N-phthaloyl amino acids using o-carbethoxythiobenzoic acid (II) or its sodium salt.
Štimac, N., Balenović, K., Gašpert, B.   +2 more
core   +1 more source

Untargeted Metabolomics Comparison and Nutrition Evaluation of Geographical Indication Newhall Navel Oranges in China

Foods
The untargeted metabolomics of Newhall navel oranges from three areas in China—Ganzhou, Fengjie, and Zigui—with geographical indication (GI) was measured using LC-MS/MS.
Xiao Shu, Manli Xie, Xuemei Zhang, Na Wang, Wei Zhang, Junjie Lin, Junying Yang, Xiaoxia Yang, Yingkui Li   +8 more
doaj   +1 more source

METABOLISM OF l-ASPARTIC ACID

Journal of Biological Chemistry, 1949
H, WU, D, RITTENBERG
openaire   +2 more sources