Results 111 to 120 of about 392,541 (251)
Advanced Science, EarlyView.A supramolecular pyroptotic thermal switch encapsulates I3− within β‐cyclodextrin (β‐CD) and undergoes CaCO3 mineralization. Upon lysosomal acidification, CaCO3 is degraded, releasing Ca2+ and I3−. Concurrently, BODIPY activation converts I3− into I2, inducing oxidative stress and Ca2+ overload, which together trigger caspase‐3/GSDME‐mediated ...
Dan Wu +8 more
wiley +1 more source
New compounds: peptide derivatives of the antitumor agent N-phosphonoacetyl-L-aspartic acid. [PDF]
, 1984 Two peptide forms of the antitumor transition state analogue N-phosphonoacetyl-L-aspartic acid (N2-phosphonoacetyl-N4-glycylglycinamidoethyl-L-asparagine and N1-glycylglycinamidoethyl-N2-phosphonoacetyl-L-isoasparagine ) have been synthesized to obtain ...
D. GIGOT +3 more
core +1 more source
Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance
Advanced Science, EarlyView.Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer +9 more
wiley +1 more source
Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.Magnetic soft robots offer promise in biomedicine due to their wireless actuation and rapid response, but current fabrication methods are complex and have limited cellular compatibility. A new, contactless bioassembly strategy using hydrodynamic instabilities is introduced, enabling customizable, centimeter‐scale robots.
Wei Gao +5 more
wiley +1 more source
35 Individuals With HUWE1‐Related Neurodevelopmental Disorder and Suggested Clinical Evaluations
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT HUWE1 (HECT, UBA, and WWE Domain Containing E3 Ubiquitin Protein Ligase1, OMIM 300697), located at Xp11.22, encodes a ubiquitin ligase that is highly conserved across species. Genetic variants in HUWE1 described in multiple independent studies cause X‐linked intellectual disability, including in the patients identified by Juberg, Marsidi, and ...
Mindy H. Li +25 more
wiley +1 more source
SYNTHESIS OF NEW NICOTINOYL AMINO ACID DERIVATIVES
Zagazig Journal of Pharmaceutical Sciences, 1994 (S)-and/or (R)-(2-methyl-3-benzyloxycarbonyl-5-oxo-4-0xazolidinyl)-acetyl chloride, prepared from S-aspartic acid, which was reacted with 3-trimethyl stannylpyridine to give the corresponding pyridyl-ketone, then converted into enantiomeric (S)-and (R)-a-
Atef Amer
doaj +1 more source
Растениевъдни науки, 2020 The effects of aspartic acid on the seed germination, seedling growth (radicle lenght, radicle number and fresh weight), mitotic index and chromosome aberrations of Allium cepa L. germinated under saline conditions were examined in this study.
Kürşat Çavuşoğlu +2 more
doaj
Arginine, glycine, aspartic acid peptide-modified paclitaxel and curcumin co-loaded liposome for the treatment of lung cancer: in vitro/vivo evaluation [PDF]
, 2018 Kanqiu Jiang,* Mingjing Shen,* Weihua Xu Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Soochow University, Suzhou Shi, Jiangsu Sheng, People’s Republic of China *These authors contributed equally to this work Purpose ...
Shen M, Jiang K, Xu W
core
Urine metabolomics in rats after administration of ketamine
Drug Design, Development and Therapy, 2015 Congcong Wen,1 Meiling Zhang,2 Jianshe Ma,2 Lufeng Hu,3 Xianqin Wang,2 Guanyang Lin31Laboratory Animal Centre, 2Analytical and Testing Center, 3First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of ChinaAbstract: In
Wen C +5 more
doaj
Introduction of the N-Phthaloyl Group into Heat-Sensitive Amino Acid Derivatives; N-Phthaloyl-L-Aspartic Acid* [PDF]
, 1957 A method is described by which heat-sensitive amino acid derivatives can be converted to unracemized N-phthaloyl amino acids using o-carbethoxythiobenzoic acid (II) or its sodium salt.
Štimac, N. +5 more
core +1 more source