Results 131 to 140 of about 13,339,760 (194)

Cholestatic Liver Failure and Hypoglycemia in a Newborn: A Mitochondrial Pathology due to Citrin Deficiency

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT In an infant with cholestasis and recurrent hypoglycemia, the combination of hypercitrullinemia, hypermethioninemia, and hyperthreoninemia should prompt testing for citrin deficiency, because early metabolic and genetic diagnosis allows targeted nutritional treatment and rapid clinical improvement.
Julien Neveu, Mathilde Butori, Anne Spraul, Charlotte Hinault‐Boyer, Mourad Naïmi   +4 more
wiley   +1 more source

Breast Cancer‐Derived AZU1 Educates Neutrophils to Promote Tumor Progression and Metastasis Through PAD4‐Dependent Extracellular Trap Formation

Molecular Carcinogenesis, Volume 65, Issue 10, Page 1281-1296, October 2026.
ABSTRACT Neutrophil extracellular traps (NETs) play crucial roles in cancer progression, but their regulatory mechanisms in breast cancer remain poorly understood. We developed a NETs‐related prognostic risk model using TCGA breast cancer data and identified key biomarkers through bioinformatics analysis.
Zhen Huang, Zhe Wu, Guiyue Zhu, Fangyu Qiu, Lihui Li, Yujie Xie, Chunyu Wei, Yinhua Pan, Quanqing Zou, Yuntian Tang   +9 more
wiley   +1 more source

Neutrophil Extracellular Traps in Atherosclerosis and Cardiovascular Disease

MedComm, Volume 7, Issue 10, October 2026.
NETs as integrated effectors in the atherosclerotic cardiovascular disease continuum. Activated neutrophils release NETs that promote endothelial injury, thrombo‐inflammation, and plaque destabilization throughout atherosclerotic disease progression. Created with BioRender.com.
Ji Zhang, Fangjiaqi Wei, Mengdi Qu, Yuwen Shao, Tingye Xu, Darko Stojkov, Hans‐Uwe Simon, Ben Huang, Changhong Miao, Hao Zhang   +9 more
wiley   +1 more source

Harnessing Quantitative Medicine to Advance Oncology Drug Development

Clinical and Translational Science, Volume 19, Issue 10, October 2026.
ABSTRACT Oncology drug development continues to have a high attrition rate despite major advances in therapeutic modalities such as antibody‐drug conjugates, bispecific antibodies, cell therapies, and cancer vaccines. Critical development decisions are often made under substantial uncertainty, creating a need for quantitative approaches that integrate ...
Benjamin Wu, Kenta Yoshida, Pascal Chanu, Chunze Li   +3 more
wiley   +1 more source

Effects of L-Citrulline Supplementation on Rumen Microbiota and Reproductive Performance of Ewes. [PDF]

Life (Basel)
Lu T, Chen H, Liu J, Li T, Lu H, Rehim R, Lv H, Gao C, Zhao G, Yang K.   +9 more
europepmc   +1 more source

Discovery of Post‐Translationally Modified Epitopes in Autoimmunity: Someone Has to Fish so Everyone Can Eat

Immunological Reviews, Volume 343, Issue 1, October 2026.
ABSTRACT Post‐translational modifications (PTMs) chemically diversify the ~20,000 genomically encoded proteins into millions of functional variants, and this diversity has profound consequences for T cell‐mediated immune responses. PTM‐reactive T cells have been identified across numerous autoimmune diseases and, in several cases, implicated directly ...
Sanya Arshad, Benjamin M. Cameron, Alok V. Joglekar   +2 more
wiley   +1 more source

Quantitative characterization of L-citrulline as a precursor of L-arginine in rats: pharmacokinetic basis for nitric oxide-mediated effects. [PDF]

Front Pharmacol
Song S, Thapa SK, Upadhyay M, Yang S, Kim T, Yoo SD, Shin BS, Shin S.   +7 more
europepmc   +1 more source

L-Citrulline: Novel Pharmacotherapy to Improve Outcomes in Infants and Children at Risk of Systemic or Pulmonary Vascular Disease. [PDF]

Pharmaceuticals (Basel)
Fike CD, Barr FE, Aschner JL.
europepmc   +1 more source

Dietary L-Citrulline Supplementation Promotes Rumen Development and Modulates the Microbiota-Metabolome Axis in Suckling Hu Lambs. [PDF]

Animals (Basel)
Tang Z, Zhang S, Xu P, Tang H, Gao W, Cao Y, Zhai R, Chen K.   +7 more
europepmc   +1 more source

Impact of L-arginine and L-citrulline supplementation on macrophage responses to <i>Mycobacterium tuberculosis</i>. [PDF]

Front Immunol
Bhargavi G, Shreeram S, Prioult G, Kumar R, Subbian S.   +4 more
europepmc   +1 more source