Results 131 to 140 of about 723,509 (268)

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Stabilizing O3-type layered oxide cathodes <i>via</i> dual-site co-doping for long-life sodium-ion batteries. [PDF]

Chem Sci
Bai X, Yang Q, Wu Y, Li M, Yu G, Huo T, Zhang X, Xu J, Zhou X, Lv T, Li L, Lei K, Zheng S.   +12 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Cryogenic magnetocaloric effect in a disordered double-perovskite Gd₂MnZnO₆. [PDF]

RSC Adv
Petrov DN, Ćwik J, Koshkid'ko YS, Babij M, Ho TA, Phan TL, Khan DT, Dang NT, My KTH, Kim DH.   +9 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Discovery of functional compounds from dimorphic edible <i>Ophiocordyceps sinensis</i> fungus in host haemolymph. [PDF]

Synth Syst Biotechnol
Sun T, Yang Y, Xie J, Rao Z, Han R, Cao L.   +5 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Four ppm measurement of the antihydrogen ground-state hyperfine splitting. [PDF]

Nature
Akbari R, de Araujo Azevedo LO, Baker CJ, Bertsche W, Bhatt NM, Bonomi G, Capra A, Carli I, L Cesar C, Charlton M, Cridland Mathad A, Del Vincio A, Duque Quiceno D, Eriksson S, Evans A, Fajans J, Friesen T, Fujiwara MC, Golino LM, Gomes Gonçalves MB, Hangst JS, Hayden ME, Heidari P, Hodgkinson D, Isaac CA, Jones SA, Jonsell S, Madsen N, Marshall VR, McKenna JTK, Momose T, Nauta J, Oliveira AN, Powell A, Rasmussen CØ, Robertson-Brown T, Robicheaux F, Sacramento RL, Sarid E, Schoonwater J, Silveira DM, Singh J, Smith G, So C, Stracka S, Suh J, Swadling AG, Tharp TD, Thompson KA, Thompson RI, Thorpe-Woods E, Uribe Jimenez AJ, Urioni M, van de Werf DP, Wilson SG, Woosaree P, Wurtele JS, ALPHA Collaboration.   +57 more
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Construction of axial chirality through addressing the <i>meta</i> constraint in the Catellani reaction. [PDF]

Chem Sci
Ge J, Liu Y, Wu X, Li Z, Zhang J, Wang X, Liu S, Cheng G.   +7 more
europepmc   +1 more source