Results 141 to 150 of about 727,385 (268)

A lattice Monte Carlo model for amyloid fibril formation. [PDF]

Biophys Physicobiol
Okumura H, Hoai LT, Sompornpisut P, Itoh SG.   +3 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Discovery of functional compounds from dimorphic edible <i>Ophiocordyceps sinensis</i> fungus in host haemolymph. [PDF]

Synth Syst Biotechnol
Sun T, Yang Y, Xie J, Rao Z, Han R, Cao L.   +5 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Cryogenic magnetocaloric effect in a disordered double-perovskite Gd₂MnZnO₆. [PDF]

RSC Adv
Petrov DN, Ćwik J, Koshkid'ko YS, Babij M, Ho TA, Phan TL, Khan DT, Dang NT, My KTH, Kim DH.   +9 more
europepmc   +1 more source

AOFT Field Structures of the TCV L–H Transition

We present a compact, data-driven visualisation of organisational dynamics during the TCV L–H transition using the Alpha–Omega Field Theory (AOFT). The effective organisational frequency f(t) = \frac{1}{2\pi}\sqrt{P_{\mathrm{heat}}(t)/W_{\mathrm{MHD}}(t)} is computed directly from experimental heating-power and stored-energy time series of a ...
openaire   +2 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Four ppm measurement of the antihydrogen ground-state hyperfine splitting. [PDF]

Nature
Akbari R, de Araujo Azevedo LO, Baker CJ, Bertsche W, Bhatt NM, Bonomi G, Capra A, Carli I, L Cesar C, Charlton M, Cridland Mathad A, Del Vincio A, Duque Quiceno D, Eriksson S, Evans A, Fajans J, Friesen T, Fujiwara MC, Golino LM, Gomes Gonçalves MB, Hangst JS, Hayden ME, Heidari P, Hodgkinson D, Isaac CA, Jones SA, Jonsell S, Madsen N, Marshall VR, McKenna JTK, Momose T, Nauta J, Oliveira AN, Powell A, Rasmussen CØ, Robertson-Brown T, Robicheaux F, Sacramento RL, Sarid E, Schoonwater J, Silveira DM, Singh J, Smith G, So C, Stracka S, Suh J, Swadling AG, Tharp TD, Thompson KA, Thompson RI, Thorpe-Woods E, Uribe Jimenez AJ, Urioni M, van de Werf DP, Wilson SG, Woosaree P, Wurtele JS, ALPHA Collaboration.   +57 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Hesperidin Inhibits Proliferation and Metastasis of Human Breast Cancer Cells by Suppressing MMP-2/9 Activity and Reversing Epithelial-Mesenchymal Transition. [PDF]

Cancer Inform
Hu H, Zhang C, Liu Z.
europepmc   +1 more source