Results 111 to 120 of about 24,681,778 (305)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
[Memorandum by H. L. McGee concerning officer's assignments #1]
, 1963 Memorandum by H. L. McGee to Captain J. W. Fritz, concerning officer's assignments during the transfer of Lee Harvey Oswald on November 24, 1963.
McGee, H. L.
core
A systematic study of the power threshold for L-H transition has been conducted in TCV. Only results from NB heated plasmas are reported. The dependencies of PLH on plasma current, plasma density and main ion species have been investigated. For Deuterium&
Vallar, Matteo +10 more
core +1 more source
Recent progress in understanding the L–H transition physics from ASDEX Upgrade. Invited Paper
, 2012 Kinetic edge profiles are measured with high spatial and temporal resolution and their behaviour before and after the time of the L-H transition is analysed.
Aumayr, Friedrich +20 more
core +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Nuclear FusionRecently, in a series of EAST discharges using deuterium neutral beam injection (NBI), tritium (T) ions were produced via deuterium–deuterium (D–D) fusion reactions, resulting in excited ion cyclotron emission (ICE) within the plasma core in H-mode ...
Huapeng Zhang +16 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
JET isotope studies and the L H transition [PDF]
Plenary talk at international conferenceThe transition between L and H-mode has fascinated plasma physicists since its discovery [1]. It is a clear phase transition between plasma confinement regimes, which takes place when the plasma is sufficiently ...
Solano, E. R., JET L2H Team
core +3 more sources
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source