Results 61 to 70 of about 694,012 (248)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Dynamics of L–H transition and I-phase in EAST

Nuclear Fusion, 2014
The turbulence and flows at the plasma edge during the L–I–H, L–I–L and single-step L–H transitions have been measured directly using two reciprocating Langmuir probe systems at the outer midplane with several newly designed probe arrays in the EAST superconducting tokamak.
Xu, GS, Wang, HQ, Xu, M, Wan, BN, Guo, HY, Diamond, PH, Tynan, GR, Chen, R, Yan, N, Kong, DF, Zhao, HL, Liu, AD, Lan, T, Naulin, V, Nielsen, AH, Rasmussen, J Juul, Miki, K, Manz, P, Zhang, W, Wang, L, Shao, LM, Liu, SC, Chen, L, Ding, SY, Zhao, N, Li, YL, Liu, YL, Hu, GH, Wu, XQ, Gong, XZ   +29 more
openaire   +4 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Non-linear dependence of ion heat flux on plasma density at the L–H transition of JET NBI-heated deuterium–tritium plasmas

Nuclear Fusion
Recent JET D–T campaigns opened the possibility of unique isotope studies to investigate the L–H transition physics in view of reactor plasmas and to study the origin of the observed power threshold minimum.
P. Vincenzi, E.R. Solano, E. Delabie, C. Angioni, G. Birkenmeier, C. Maggi, R.B. Morales, H.J. Sun, E. Tholerus, JET Contributors   +9 more
doaj   +1 more source

D-shaped configurations in FTU for testing liquid lithium limiter: Preliminary studies and experiments

Nuclear Materials and Energy, 2017
The feasibility of getting “D” shaped plasma configurations in FTU, with a possible X point close to the first wall, has been investigated with the aim of achieving an H-mode regime in this machine.
G. Ramogida, G. Calabrò, F. Crisanti, M.L. Apicella, G. Artaserse, W. Bin, L. Boncagni, G. Brolatti, P. Buratti, M. Carlini, D. Carnevale, P. Costa, F. Crescenzi, A. Cucchiaro, D. Frigione, S. Garavaglia, M. Gospodarcyk, G. Granucci, M. Iafrati, A. Lampasi, G. Maddaluno, G. Maffia, F. Maviglia, G. Mazzitelli, R. Mazzuca, M. Moneti, A. Moro, G. Pucella, M. Reale, S. Roccella, F. Starace, A.A. Tuccillo, A. Vertkov, P. Zito   +33 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Heating neutral beams for ITER: negative ion sources to tune fusion plasmas

New Journal of Physics, 2017
Neutral beam injection (NBI) based on a negative ion source is one of the basic heating and current drive systems designed for ITER required to reach its goals of the operation with high fusion power, P _fus  ∼ 500 MW with fusion gain, Q  = 10 for 400 s ...
M J Singh, D Boilson, A R Polevoi, Toshihiro Oikawa, Raphael Mitteau   +4 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source