Results 61 to 70 of about 723,509 (268)
LandChina has effectively safeguarded biodiversity by building the world’s largest system of nature reserves, but the livelihoods of farmers near the reserves are often not guaranteed. This paper aimed to deeply explore the intrinsic relationship between the
Changhai Wang +3 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Nuclear FusionRecent JET D–T campaigns opened the possibility of unique isotope studies to investigate the L–H transition physics in view of reactor plasmas and to study the origin of the observed power threshold minimum.
P. Vincenzi +9 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gravitational waves from phase transition in a supersymmetric left-right model
Journal of High Energy PhysicsWe investigate the cosmological phase transition dynamics in a supersymmetric left-right symmetric model based on the gauge group SU(3) C × SU(2) L × SU(2) R × U(1) B−L that addresses the strong CP problem through extended parity symmetry and doublet ...
Naoyuki Haba +2 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Heating neutral beams for ITER: negative ion sources to tune fusion plasmas
New Journal of Physics, 2017 Neutral beam injection (NBI) based on a negative ion source is one of the basic heating and current drive systems designed for ITER required to reach its goals of the operation with high fusion power, P _fus ∼ 500 MW with fusion gain, Q = 10 for 400 s ...
M J Singh +4 more
doaj +1 more source
Nuclear Materials and Energy, 2017 The feasibility of getting “D” shaped plasma configurations in FTU, with a possible X point close to the first wall, has been investigated with the aim of achieving an H-mode regime in this machine.
G. Ramogida +33 more
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source