Results 181 to 190 of about 13,429,421 (274)

Functional Specialization of Respiratory and Olfactory Mucus Revealed by Proteomic Profiling

open access: yesInternational Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Mucus overlies the nasal mucosa in the respiratory and olfactory regions, which perform distinct physiological functions. However, proteomic differences between respiratory mucosa (RM) and olfactory cleft (OC) mucus remain unclear.
Anna Kristina Hernandez   +7 more
wiley   +1 more source

SOLiD‐MaP: A Photoproximity Labeling Platform for Small Molecule Binding Site Mapping on RNA

open access: yesAngewandte Chemie, EarlyView.
SOLiD‐MaP is a ligand‐directed photoproximity labeling strategy developed for RNA binding‐site analysis. Singlet oxygen‐mediated labeling creates a proximity‐dependent chemical footprint of bound small molecules on RNA. Coupling this chemistry with mutational profiling enables identification of the ligand‐binding region at nucleotide resolution ...
Lin L. Rietveld   +4 more
wiley   +2 more sources

Decarboxylation of L-histidine by Clostridia [PDF]

open access: yesInternational Journal of Systematic Bacteriology, 1967
M. FRIEDRICH, S. STEINER, R. H. WEAVER
openaire   +1 more source

Chirality‐Driven Piezocatalysis in MOFs: Achieving Efficient Cocatalyst‐Free Hydrogen Evolution

open access: yesAngewandte Chemie, EarlyView.
We report a chirality‐driven post‐synthetic modification strategy that grafts chiral L‐histidine (L‐His) onto the Hf6 clusters of MOF‐808(Hf), which significantly boosts the piezoelectricity and charge transfer efficiency, thus significantly enhancing the piezocatalytic performance of MOF‐808(Hf).
Yali Ma   +7 more
wiley   +2 more sources

Structure and Function of a Multi‐Megadalton Virus‐Like Proteolytic Dodecahedron

open access: yesAngewandte Chemie, EarlyView.
Zuzalysin, a virulence metallopeptidase of the periodontal pathogen Porphyromonas gingivalis, is secreted as a latent, flexible ≈95‐kDa monomer. Calcium triggers cysteine‐switch activation and hierarchical assembly into pentamers, bipentamers, tripentamers, and a ≈5.6‐MDa, ≈355‐Å dodecahedron. Structures at 1.8–3.6 Å reveal a virus‐sized catalytic cage
Mariusz Madej   +20 more
wiley   +2 more sources

Should I Stay or Should I Go—Leveraging an Overlooked Feature of Click‐to‐Release Chemistry for Affinity Labeling

open access: yesAngewandte Chemie, EarlyView.
Click‐to‐release (C2R) chemistry is redirected from payload liberation toward ligand‐directed covalent protein labeling through a transient dihydropyridazine methide (DHP‐methide). This concept opens the way to dual‐functional systems combining covalent target engagement with controlled effector release.
Dóra Kern   +9 more
wiley   +2 more sources

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